Figure 2.
Fig. 2. Alignment of the PDK2 nucleotide-binding domain
with prokaryotic histidine kinases and ATPases. This figure
shows a composite of the C tracings of
the ATP-binding domains of the structurally homologous ATPases
Hsp90 (Protein Data Bank (36) code 1AM1) residues 26-209, MutL
(1B62) residues 22-201, and DNA Gyrase B (1EI1) residues
452-619, as well as the histidine kinase CheA (1B3Q) residues
354-538, all of which were aligned with the C-terminal domain of
PDK2, residues 183-353, using the program TOP3D (17). The
backbone for all structures is shown in gray, and the nucleotide
is shown in color. Visualization was done with Swiss-PdbViewer
(38), and rendering was done with POV-Ray for Windows.
tracings of
the ATP-binding domains of the structurally homologous ATPases
Hsp90 (Protein Data Bank (36) code 1AM1) residues 26-209, MutL
(1B62) residues 22-201, and DNA Gyrase B (1EI1) residues
452-619, as well as the histidine kinase CheA (1B3Q) residues
354-538, all of which were aligned with the C-terminal domain of
PDK2, residues 183-353, using the program TOP3D (17). The
backbone for all structures is shown in gray, and the nucleotide
is shown in color. Visualization was done with Swiss-PdbViewer
(38), and rendering was done with POV-Ray for Windows.