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Figure 2.
Figure 2. Comparison of the three-dimensional structures of
calcyclin and calbindin D[9k] in the Ca^2+-bound state. Overview
of calbindin D[9k] (a) and the calcyclin subunit (b),
highlighting the conserved residues in the hydrophobic core
(cyan). The two structures were first overlaid by best-fit
superposition of the backbone atoms of helices I, II and IV,
then separated for viewing. (c) Stereo close-up view of the
conserved hydrophobic residues at the interface between helices
I and IV, showing the similarity in the packing of corresponding
sidechains. The structures were overlaid by best-fit
superposition of the backbone atoms of helices I and IV.
Calbindin D[9k] is shown in yellow and calcyclin is in salmon;
the sidechains are labeled for calcyclin only. The coordinates
for calbindin D[9k] were obtained from the Brookhaven PDB
(accession code 2BCB). (Figure prepared using Insight II
[Version 95.0; MSI, San Diego].)
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