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Figure 1.
(a) Secondary structure. Thin lines denote connectivity;
outlined letters denote disordered nucleotides (base-pairing
symbols follow those of ref. 14). Not shown are tertiary
interactions between S1 and L3. (b) Structure cartoon. Gray,
yellow and red spheres depict the disordered portion of L2,
Ca^2+ and water, respectively. (c) Select L3 tertiary
interactions. (d) Partially hydrated Ca^2+ ions stabilize the L1
turn. a and b depict the wild-type^2 structure, and c and d
depict the sequence variant^4.
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