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Figure 1.
Fig. 1. Crystal structure of PHS/L38E (pink, PDB accession
code 3D6C) overlaid on the structures of PHS/L38K (blue, PDB
accession code 2RKS) and PHS nuclease (white, PDB accession code
1EY8). (a) The global fold of the protein is not perturbed. The
C^α atoms of Asp and Glu residues are shown as red spheres.
Glu38, Lys38, and Glu122 are shown as sticks. (b)
Microenvironment of Glu38 and Lys38. Ionizable residues within
8.4 Å of Glu38 are shown in stick, and hydrogen bonds are
shown as broken lines.
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