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Figure 1.
Figure 1. The currently accepted mechanism of asparagine
nonenzymatic deamidation.[11][12] The succinimide intermediate
formation arises from a nucleophilic attack of the backbone NH
group of the next residue on the side-chain carbonyl of the
asparaginyl residue. The ring is hydrolyzed to open, resulting
in either an aspartic acid or isoaspartic acid product.
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