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Figure 1.
FIGURE 1. Ligation and hydrolytic reactions catalyzed by
trypanothione synthetase-amidase. Trypanothione is produced by
stepwise ligation of glutathione with spermidine (reaction I),
then glutathionylspermidine (reaction II). Hydrolysis of
trypanothione (reaction III) then glutathionylspermidine
(reaction IV) is performed by the N-terminal amidase domain.
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