|
Figure 1.
Figure 1. Superimposition of structures of HIV-1 PR mutants
in complex with nelfinavir. The positions of mutations are
indicated by spheres and numbered. The protease is shown in
ribbon representation. The D30N/N88D mutant is colored red, the
D30N/A71V mutant yellow, the D30/L90M mutant green and the D30N
mutant blue. Nelfinavir is represented as a stick model and its
solvent accessible surface is colored according to electrostatic
potential: blue, positive; red, negative (calculated with DS
ViewerPro 6.0 (Accelerys Software Inc.)).
|
