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Figure 1.
(a) Domain architecture and partial sequence of human APLF.
The PBZ modules (F1 and F2) are boxed, metal-binding residues
are pink, key PAR-binding residues are violet and the additional
loop of F1 is orange. Highly conserved residues are bold
(Supplementary Fig. 11), and asterisks indicate residues mutated
in our study. (b) Solution structures of APLF F1 and F2, colored
as in a with zinc ions as blue spheres and helices dark red; the
ten lowest-energy structures are shown. Structural statistics
appear in Supplementary Table 1 and Supplementary Figure 2.
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