|
Figure 1.
FIGURE 1. Overall structure of the SCV RBD in complex with
the neutralizing antibody Fab m396. The SCV RBD is in green, and
the prominent neutralizing site comprising residues 482 through
491 (  6– 7 loop) is in red. The
side chains of two important residues, Ile-489 and Tyr-491, of
the loop are shown as sticks. A portion of the structure shown
in brown constitutes the 16 amino acid residues that were not
observed in the RBD·ACE2 structure (20). The light and
heavy chains of the Fab are shown in cyan and yellow,
respectively, with labeled CDRs, H1, H2, H3, and L3, which make
contacts with the RBD.
|
