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Figure 1.
Fig. 1. Crystal structure of the DHFR domain of P. vivax.
(A) Structure of P. vivax DHFR complexed with NADPH and Pyr;
 -helices are in red,
and  -strands are in blue,
including the Insert-1 loop and the Insert-2 -helix. The carbons,
nitrogen, oxygen, and chlorine atoms of Pyr and NADPH are shown
in yellow, blue, red, and magenta, respectively. (B) Comparison
of the DHFR domains from P. vivax (green) and P. falciparum
(magenta). The superimposed structures demonstrate overall
structural similarity with major deviation in the insert regions.
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