Figure 1.
Fig. 1. Electron density in the main cavity of T4 lysozyme
mutant L99A at high pressure. Helix E is shown behind a cut-away
view of the 160-Å^3 cavity. (A)
Experimental density at 100 MPa (yellow), 150 MPa (cyan), and
200 MPa (magenta) is contoured at 0.1 electrons per Å^3.
(B) Experimental electron density at 150 MPa (cyan) compared
with simulation density at 200 MPa (magenta), contoured at 0.1
electrons per Å^3, viewed as described above. The
distribution of atoms at 100 MPa (using the occupancies of N =
1, 2, 3, 4, 5 at 200 MPa) is shown in yellow for comparison.
160-Å^3 cavity. (A)
Experimental density at 100 MPa (yellow), 150 MPa (cyan), and
200 MPa (magenta) is contoured at 0.1 electrons per Å^3.
(B) Experimental electron density at 150 MPa (cyan) compared
with simulation density at 200 MPa (magenta), contoured at 0.1
electrons per Å^3, viewed as described above. The
distribution of atoms at 100 MPa (using the occupancies of N =
1, 2, 3, 4, 5 at 200 MPa) is shown in yellow for comparison.