Figure 1 - full size

Figure 1. Fig. 1. Schematic representation of dG-AAF and dG-AF. The anti conformation (a) is energetically favored for unmodified dG. dG-AF (b) can be in anti conformation or syn conformation. However, for dG-AAF (c), the anti conformation is strongly unfavorable because of the steric hindrance between the acetyl group (circled in green) and the sugar moiety (circled in pink).