Figure 1 - full size

Figure 1. Figure 1 Structure of the Ly49A/H-2D^d complex and the interaction sites. a, Stereo diagram of the complex and crystal packing interactions. View shows the asymmetric interaction between an Ly49A dimer and two H-2D^d molecules related by the crystal symmetry. The H-2D^d heavy chain is yellow, [2]m is grey, and the two Ly49A subunits, Ly49A-1 and Ly49A-2, are cyan and blue, respectively, whereas the viral peptide is shown in orange ball-and-stick representation. The two interaction surfaces, site 1 and site 2, are indicated by a red circle and a black rectangle, respectively. b, c, Detailed view of site 1 showing the interactions using a common orientation based on the 'standard' view for the MHC-I molecule. c, Close up of the interactions at site 1. The view has been rotated around the horizontal relative to b and depicts the region highlighted by a box. d, e, As in b, c but for site 2. The two domains of the MHC-I peptide-binding platform are shown in cream ( 1) and dark yellow ( 2). Hydrogen bonds between Ly49A and H-2D^d are depicted as broken lines. All figures were drawn using programs BOBSCRIPT49 and Raster3D^50.