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Figure 1.
FIG. 1. Tubulin-binding anti-cancer drugs. a, structure of
epothilones and epoxidation reaction catalyzed by P450epoK.
Epothilones D and B have higher tubulin polymerization activity
and cytotoxicity than epothilones C and A, respectively (8, 45).
b, paclitaxel. Taxane skeleton is composed of rings A-D. c,
eleutherobin; d, sarcodictyin; e, discodemolide.
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