Figure 1 - full size

Figure 1.
Figure 1. Overall structure of double-hexamer of N-mtMCM. a, Side view of the double-hexamer structure. Each monomer is represented by a discrete color. The -helices are represented by cylinders; and -strands, by arrows. The 12 Zn atoms (magenta) are located in the middle of the double hexamer, mediating hexamer -hexamer interactions. The figure was generated with MolScript44. b, A surface representation of the double hexamer, showing a dumbbell-like shape. The figure was generated with GRASP45. c, The packing of the double hexamers in the crystal, viewed along the two-fold and normal to the three-fold crystallographic axis. Three consecutive double hexamers (in blue, magenta and green) are stacked end-to-end against each other.