Figure 1.
Figure 1. a, Stereoview showing the best-fit superposition of
the backbone atoms (N, C ,
and C') of the final 15 structures of the nNOS PDZ−MelR
peptide complex. The structures are superimposed against the
average structure using the residues 14−98. The MelR peptide
(VVKVDSV) is shown in pink. The -strands
in the C-terminal extension are in orange, and the rest of the
extension is in cyan. b, Superposition of the 15 NMR structures
using the 'I
and 'II
showing the defined structure of the C-terminal extension of the
nNOS PDZ domain. c, Ribbon diagram of the nNOS PDZ−MelR
peptide complex. The secondary structural elements of the
canonical nNOS PDZ domain are labeled following the scheme of
the crystal structure of the PSD-95 PDZ domain^7. The MelR
peptide is shown in pink, and the C-terminal extension is in
yellow. The two C-terminal strands are named 'I
and 'II,
respectively.
,
and C') of the final 15 structures of the nNOS PDZ−MelR
peptide complex. The structures are superimposed against the
average structure using the residues 14−98. The MelR peptide
(VVKVDSV) is shown in pink. The 
-strands
in the C-terminal extension are in orange, and the rest of the
extension is in cyan. b, Superposition of the 15 NMR structures
using the