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Figure 1.
Figure 1. General Architecture of Chaperonins(A) Side view
of the hexadecameric thermosome structure.(B) Side view of the
asymmetric GroEL-GroES-(ADP)[7] complex ([77]).Domains are
colored in red (equatorial), green (intermediate), and yellow
(apical). Within each complex domains of aligned subunits are
highlighted in blue (equatorial), light blue (intermediate), and
violet (apical). Bound ADP is drawn in yellow.(C) Top view of
the thermosome α (red/violet) and β (yellow) apical domains.
β strands S12 and S13 and the N-terminal half of helix H10 (lid
segments) form the lid domain that seals off the central
chamber. Helices H10 and H11 and loop L topologically correspond
to helices H and I and the loop connecting β strands 6 and 7 in
GroEL that are involved in substrate and/or GroES binding.Figure
1A Figure 1B Figure 3 Figure 5, and Figure 6A were generated
using BOBSCRIPT ( [18]) and RASTER3D ( [3 and 54]). Figure 1C
was prepared with MOLSCRIPT ( [41]) as modified by D. Peisach
and E. Peisach and with POVRAY.
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