EC 6.3.1.22 - tRNAmet cytidine acetate ligase.

_EC 6.3.1.22 tRNAmet cytidine acetate ligase.

0 PDB entries

EC 6.-.-.- Ligases. [3,414 PDB entries]

EC 6.3.-.- Forming carbon-nitrogen bonds. [1,455 PDB entries]

EC 6.3.1.- Acid--ammonia (or amine) ligases (amide synthases). [151 PDB entries]

EC 6.3.1.22 tRNAmet cytidine acetate ligase. [-]

Reaction: cytidine(34) in elongator tRNA(Met) + acetate + Atp = N(4)- acetylcytidine(34) in elongator tRNA(Met) + Amp + diphosphate.

cytidine(34) in elongator tRNA(Met)
+
acetate
+
ATP
= N(4)- acetylcytidine(34) in elongator tRNA(Met)
+
AMP
+
diphosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Comments: The enzyme, charactrized from the bacterium Bacillus subtilis, catalyzes a similar tRNA modification to that performed by Ec 2.3.1.193. However, unlike that enzyme, which uses acetyl-CoA as the acetyl donor, this enzyme activates an acetate ion to form acetyladenylate and then catalyzes the acetylation through a mechanism similar to tRNA aminoacylation.

Links: [IntEnz] [ExPASy] [KEGG]

There are no PDB entries in enzyme class E.C.6.3.1.22