_EC 6.1.1.15 Proline--tRNA ligase. 21 PDB entries  
EC 6.-.-.- Ligases. [1,685 PDB entries]
EC 6.1.-.- Forming carbon-oxygen bonds. [564 PDB entries]
EC 6.1.1.- Ligases forming aminoacyl-tRNA and related compounds. [553 PDB entries]
EC 6.1.1.15 Proline--tRNA ligase. [21 PDB entries]    
1d2d

Reaction: Atp + L-proline + tRNA(Pro) = amp + diphosphate + L-prolyl-tRNA(Pro).
 


ATP
+
L-proline
+
tRNA(Pro)
=
AMP
+
diphosphate
+
L-prolyl-tRNA(Pro)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Proline translase. Prolyl-tRNA synthetase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 21 PDB entries in enzyme class E.C.6.1.1.15

  PDB code Protein
1d2d
Hamster eprs second repeated element. Nmr, 5 structures
Source: Cricetulus griseus. Chinese hamster. Organism_taxid: 10029. Organ: ovary cells. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (56 residues) CATH domain: 1.10.287.10
1fyj
Solution structure of multi-functional peptide motif-1 present in human glutamyl-prolyl tRNA synthetase (eprs).
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (57 residues) CATH domain: 1.10.287.10
1h4q
Prolyl-tRNA synthetase from thermus thermophilus complexed with trnapro(cgg), atp and prolinol
Source: Thermus thermophilus. Organism_taxid: 274. Strain: hb-8. Other_details: purification of protein described in reference 2. Other_details: purification of trnapro described in reference 3
Chains: A, B (465 residues) CATH domains: 3.30.930.10 3.40.50.800 3.30.110.30
Bound ligands:   Het Group ATP corresponds to enzyme reactant ATP
  Het Group PRI is 87.00% similar to enzyme reactant L-proline
1h4s
Prolyl-tRNA synthetase from thermus thermophilus complexed with trnapro(cgg) and a prolyl-adenylate analogue
Source: Thermus thermophilus. Organism_taxid: 274. Strain: hb-8. Other_details: purification of protein described in reference 2. Other_details: purification of trnapro described in reference 3
Chains: A, B (473 residues) CATH domains: 3.30.930.10 3.40.50.800 3.30.110.30
Bound ligand:   Het Group PSD is 70.00% similar to enzyme product AMP
1h4t
Prolyl-tRNA synthetase from thermus thermophilus complexed with l-proline
Source: Thermus thermophilus. Organism_taxid: 274. Strain: hb-8. Other_details: purification described in reference 2
Chains: A, B, C, D (464 residues) CATH domains: 3.30.930.10 3.40.50.800 3.30.110.30
Bound ligand:   Het Group PRO corresponds to enzyme reactant L-proline
1hc7
Prolyl-tRNA synthetase from thermus thermophilus
Source: Thermus thermophilus. Organism_taxid: 274. Strain: hb-8. Gene: pros. Other_details: purification described in reference 2
Chains: A, B, C, D (464 residues) CATH domains: 3.30.930.10 3.40.50.800 3.30.110.30
1nj1
Crystal structure of prolyl-tRNA synthetase from methanother thermautotrophicus bound to cysteine sulfamoyl adenylate
Source: Methanothermobacter thermautotrophicus organism_taxid: 145262. Gene: mth611. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: strain supplemented with additional plasmid rare trnas
Chain: A (463 residues) CATH domains: 3.30.930.10 3.40.50.800 3.30.110.30
Bound ligand:   Het Group 5CA is 57.58% similar to enzyme product AMP
1nj2
Crystal structure of prolyl-tRNA synthetase from methanother thermautotrophicus
Source: Methanothermobacter thermautotrophicus organism_taxid: 187420. Strain: delta h. Gene: mth611. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: strain supplemented with additional plasmid rare trnas
Chain: A (452 residues) CATH domains: 3.30.930.10 3.40.50.800 3.30.110.30
1nj5
Crystal structure of prolyl-tRNA synthetase from methanother thermautotrophicus bound to proline sulfamoyl adenylate
Source: Methanothermobacter thermautotrophicus organism_taxid: 187420. Strain: delta h. Gene: mth611. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: strain supplemented with additional plasmid rare trnas
Chain: A (463 residues) CATH domains: 3.30.930.10 3.40.50.800 3.30.110.30
Bound ligand:   Het Group P5A is 55.88% similar to enzyme product AMP
1nj6
Crystal structure of prolyl-tRNA synthetase from methanother thermautotrophicus bound to alanine sulfamoyl adenylate
Source: Methanothermobacter thermautotrophicus organism_taxid: 187420. Strain: delta h. Gene: mth611. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: strain supplemented with additional plasmid rare trnas
Chain: A (463 residues) CATH domains: 3.30.930.10 3.40.50.800 3.30.110.30
Bound ligand:   Het Group A5A is 59.38% similar to enzyme product AMP
1nj8
Crystal structure of prolyl-tRNA synthetase from methanocaldococcus janaschii
Source: Methanocaldococcus jannaschii. Organism_taxid: 2190. Gene: mj1238. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: strain supplemented with additional plasmid encoding rare trnas
Chains: A, B, C, D (456 residues) CATH domains: 3.30.930.10 3.40.50.800 3.30.110.30
1r1b
Eprs second repeated element, nmr, minimized average structure
Source: Cricetulus griseus. Chinese hamster. Organism_taxid: 10029. Organ: ovary cells. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (56 residues) CATH domain: 1.10.287.10
2j3l
Prolyl-tRNA synthetase from enterococcus faecalis complexed with a prolyl-adenylate analogue ('5'-o-(n-(l-prolyl)- sulfamoyl)adenosine)
Source: Enterococcus faecalis. Organism_taxid: 1351. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (565 residues) CATH domains: 3.40.50.800 3.30.930.10 3.90.960.10
Bound ligand:   Het Group P5A is 55.88% similar to enzyme product AMP
2j3m
Prolyl-tRNA synthetase from enterococcus faecalis complexed with atp, manganese and prolinol
Source: Enterococcus faecalis. Organism_taxid: 1351. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (554 residues) CATH domains: 3.40.50.800 3.30.930.10 3.90.960.10
Bound ligands:   Het Group ATP corresponds to enzyme reactant ATP
  Het Group PRI is 87.00% similar to enzyme reactant L-proline
3ial
Giardia lamblia prolyl-tRNA synthetase in complex with proly adenylate
Source: Giardia lamblia atcc 50803. Organism_taxid: 184922. Gene: gl50803_15983, prors. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (496 residues) CATH domains: 3.30.930.10 3.40.50.800 3.30.110.30
Bound ligands:   Het Group GOL is 40.00% similar to enzyme reactant L-proline
  Het Group PR8 is 76.67% similar to enzyme product AMP
4hvc
Crystal structure of human prolyl-tRNA synthetase in complex halofuginone and atp analogue
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eprs, glns, pars, qars, qprs, pig32. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (482 residues) CATH domains: 3.30.930.10 3.40.50.800 3.30.110.30
4k86
Crystal structure of human prolyl-tRNA synthetase (apo form)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eprs. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (488 residues) CATH domains: 3.30.930.10 3.40.50.800 3.30.110.30
4k87
Crystal structure of human prolyl-tRNA synthetase (substrate form)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eprs. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (490 residues) CATH domains: 3.30.930.10 3.40.50.800 3.30.110.30
Bound ligands:   Het Group PRO corresponds to enzyme reactant L-proline
  Het Group ADN is 82.61% similar to enzyme product AMP
4k88
Crystal structure of human prolyl-tRNA synthetase (halofugin form)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eprs. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (490 residues) CATH domains: 3.30.930.10 3.40.50.800 3.30.110.30
4ncx
Crystal structure of prolyl-tRNA synthetase (prors, proline- ligase) from plasmodium falciparum 3d7
Source: Plasmodium falciparum 3d7. Organism_taxid: 36329. Strain: 3d7. Gene: prors, pfl0670c. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (449 residues)
4twa
Crystal structure of prolyl-tRNA synthetase (prs) from plasm falciparum
Source: Plasmodium falciparum. Organism_taxid: 36329. Strain: isolate 3d7. Gene: prors, pfl0670c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (488 residues) CATH domains: 3.30.930.10 3.40.50.800 3.30.110.30