_EC 5.6.2.5 Rna 5'-3' helicase.

0 PDB entries

EC 5.-.-.- Isomerases. [5,284 PDB entries] EC 5.6.-.- Isomerases altering macromolecular conformation. [1,148 PDB entries] EC 5.6.2.- Enzymes altering nucleic acid conformation. [871 PDB entries] EC 5.6.2.5 Rna 5'-3' helicase. [-]

Reaction:		n Atp + n H2O + wound rna = n adp + n phosphate + unwound rna.
		n ATP + n H2O + wound RNA = n ADP + n phosphate + unwound RNA Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments:		Rna helicases, which participate in nearly all aspects of rna metabolism, utilize the energy from Atp hydrolysis to unwind rna. The engine core of helicases is usually made of a pair of RecA-like domains that form an Ntp binding cleft at their interface. Changes in the chemical state of the Ntp binding cleft (binding of the Ntp or its hydrolysis products) alter the relative positions of the RecA-like domains and nucleic acid-binding domains, creating structural motions that disrupt the pairing of the nucleic acid, causing separation and unwinding. Most Rna helicases utilize a mechanism known as canonical duplex
Links:		[IntEnz]   [ExPASy]   [KEGG]

There are no PDB entries in enzyme class E.C.5.6.2.5