_EC 4.6.1.12 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase.

73 PDB entries

EC 4.-.-.- Lyases. [10,244 PDB entries] EC 4.6.-.- Phosphorus-oxygen lyases. [904 PDB entries] EC 4.6.1.- Phosphorus-oxygen lyases. [904 PDB entries] EC 4.6.1.12 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. [73 PDB entries]

1gx1

Reaction:		4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4- cyclic diphosphate + Cmp.
		4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4- cyclic diphosphate + CMP Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Other name(s):		MECDP-synthase.
Comments:		Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.
Links:		[IntEnz]   [ExPASy]   [KEGG]

There are 73 PDB entries in enzyme class E.C.4.6.1.12

PDB code		Protein
1gx1		Structure of 2c-methyl-d-erythritol-2,4-cyclodiphosphate synthase Source: Escherichia coli. Organism_taxid: 511693. Strain: bl21. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: synthetic gene Chains: A, B, C (157 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group CDP is 84.00% similar to enzyme product CMP
1h47		Structures of mecp synthase in complex with (i) cmp and (ii) cmp and product Source: Escherichia coli. Organism_taxid: 511693. Strain: bl21. Expressed in: escherichia coli. Expression_system_taxid: 511693. Chains: A, B, C, D, E, F (157 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group C5P corresponds to enzyme product CMP
1h48		The structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase in complex with cmp and product Source: Escherichia coli. Organism_taxid: 511693. Strain: bl21. Expressed in: escherichia coli. Expression_system_taxid: 511693. Chains: A, B, C, D, E, F (157 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group C5P corresponds to enzyme product CMP
1iv1		Structure of 2c-methyl-d-erythritol-2,4-cyclodiphosphate synthase Source: Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, C, D, B, E, F (150 residues) CATH domain: 3.30.1330.50
1iv2		Structure of 2c-methyl-d-erythritol-2,4-cyclodiphosphate synthase (bound form cdp) Source: Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C, D, E, F (150 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group CDP is 84.00% similar to enzyme product CMP
1iv3		Structure of 2c-methyl-d-erythritol-2,4-cyclodiphosphate synthase (bound form mg atoms) Source: Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C, D, E, F (150 residues) CATH domain: 3.30.1330.50
1iv4		Structure of 2c-methyl-d-erythritol-2,4-cyclodiphosphate synthase (bound form substrate) Source: Thermus thermophilus. Organism_taxid: 274. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C, D, E, F (150 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group C5P corresponds to enzyme product CMP
1jn1		Structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from haemophilus influenzae (hi0671) Source: Haemophilus influenzae. Organism_taxid: 727. Gene: ispf. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B, C (157 residues) CATH domain: 3.30.1330.50
1jy8		2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase (ispf) Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (155 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group C5P corresponds to enzyme product CMP
1knj		Co-crystal structure of 2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase (ispf) from e. Coli involved in mevalonate-independent isoprenoid biosynthesis, complexed with cmp/mecdp/mn2+ Source: Escherichia coli. Organism_taxid: 562. Gene: ispf. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chain: A (156 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group C5P corresponds to enzyme product CMP
1knk		Crystal structure of 2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase (ispf) from e. Coli involved in mevalonate-independent isoprenoid biosynthesis Source: Escherichia coli. Organism_taxid: 562. Gene: ispf. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chain: A (156 residues) CATH domain: 3.30.1330.50
1t0a		Crystal structure of 2c-methyl-d-erythritol-2,4-cyclodiphosphate synthase from shewanella oneidensis Source: Shewanella oneidensis. Organism_taxid: 211586. Strain: mr-1. Gene: ispf. Expressed in: escherichia coli k12. Expression_system_taxid: 83333. Chains: A, B, C (158 residues) CATH domain: 3.30.1330.50
1u3l		Ispf with mg and cdp Source: Escherichia coli. Organism_taxid: 562. Gene: ispf. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (155 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group CDP is 84.00% similar to enzyme product CMP
1u3p		Ispf native Source: Escherichia coli. Organism_taxid: 562. Gene: ispf, mecs. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (155 residues) CATH domain: 3.30.1330.50
1u40		Ispf with 4-diphosphocytidyl-2c-methyl-d-erythritol Source: Escherichia coli. Organism_taxid: 562. Gene: ispf. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (155 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group CDM is 63.64% similar to enzyme product CMP
1u43		Ispf with 4-diphosphocytidyl-2c-methyl-d-erythritol 2-phosphate Source: Escherichia coli. Organism_taxid: 562. Gene: ispf, mecs. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (155 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group SUD is 56.76% similar to enzyme product CMP
1vh8		Crystal structure of a 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase Source: Haemophilus influenzae. Organism_taxid: 727. Gene: ispf, hi0671. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B, C, D, E, F (153 residues) CATH domain: 3.30.1330.50
1vha		Crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase Source: Haemophilus influenzae. Organism_taxid: 727. Gene: ispf, hi0671. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B, C, D, E, F (153 residues) CATH domain: 3.30.1330.50
1w55		Structure of the bifunctional ispdf from campylobacter jejuni Source: Campylobacter jejuni. Organism_taxid: 197. Strain: jejuni ntct 11168. Atcc: 33560. Expressed in: escherichia coli. Expression_system_taxid: 511693. Chain: A (369 residues) CATH domains: 3.90.550.10 3.30.1330.50 Bound ligand:   Het Group C corresponds to enzyme product CMP
1w57		Structure of the bifunctional ispdf from campylobacter jejuni containing zn Source: Campylobacter jejuni. Organism_taxid: 197. Strain: jejuni ntct 11168. Atcc: 33560. Expressed in: escherichia coli. Expression_system_taxid: 511693. Chain: A (368 residues) CATH domains: 3.90.550.10 3.30.1330.50 Bound ligand:   Het Group C5P corresponds to enzyme product CMP
1yqn		E. Coli ispf double mutant Source: Escherichia coli. Organism_taxid: 562. Gene: ispf. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chain: A (158 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group CDP is 84.00% similar to enzyme product CMP
2amt		Structure of 2c-methyl-d-erythritol 2,4-clycodiphosphate synthase complexed with a cdp derived fluorescent inhibitor Source: Escherichia coli. Organism_taxid: 562. Gene: ispf, mecs. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Chains: A, B, C, D, E, F (156 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group 1AA is 56.76% similar to enzyme product CMP
2gzl		Structure of 2c-methyl-d-erythritol 2,4-clycodiphosphate synthase complexed with a cdp derived fluorescent inhibitor Source: Escherichia coli. Organism_taxid: 562. Gene: ispf, mecs. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Chain: A (159 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group 2AA is 47.73% similar to enzyme product CMP
2pmp		Structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from the isoprenoid biosynthetic pathway of arabidopsis thaliana Source: Arabidopsis thaliana. Thale cress. Organism_taxid: 3702. Strain: ecotype columbia 0. Gene: ispf. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (160 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group C5P corresponds to enzyme product CMP
2uzh		Mycobacterium smegmatis 2c-methyl-d-erythritol-2,4-cyclodiphosphate synthase (ispf) Source: Mycobacterium smegmatis. Organism_taxid: 1772. Strain: mc(2)155. Atcc: 700084. Expressed in: escherichia coli. Expression_system_taxid: 469008. Chains: A, B, C (153 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group CDP is 84.00% similar to enzyme product CMP
3b6n		Crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase pv003920 from plasmodium vivax Source: Plasmodium vivax sai-1. Organism_taxid: 126793. Strain: salvador i. Gene: pv003920, pvx_003920. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (150 residues) CATH domain: 3.30.1330.50
3elc		Crystal structure of 2c-methyl-d-erythritol 2,4-clycodiphosphate synthase complexed with ligand Source: Escherichia coli k-12. Organism_taxid: 83333. Strain: k12. Gene: ispf. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B, C (157 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group F01 is 77.27% similar to enzyme product CMP
3eor		Crystal structure of 2c-methyl-d-erythritol 2,4-clycodiphosphate synthase complexed with ligand Source: Escherichia coli k-12. Organism_taxid: 83333. Strain: k12. Gene: ispf. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chain: A (157 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group CFV is 50.00% similar to enzyme product CMP
3ern		Crystal structure of 2c-methyl-d-erythritol 2,4-clycodiphosphate synthase complexed with aracmp Source: Escherichia coli k-12. Organism_taxid: 83333. Strain: k12. Gene: ispf. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B, C, D, E, F (157 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group CAR corresponds to enzyme product CMP
3esj		Crystal structure of 2c-methyl-d-erythritol 2,4-clycodiphosphate synthase complexed with ligand Source: Escherichia coli k-12. Organism_taxid: 83333. Strain: k12. Gene: ispf. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chain: A (162 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group CC7 is 95.24% similar to enzyme product CMP
3f0d		High resolution crystal structure of 2c-methyl-d-erythritol 2,4- cyclodiphosphatase synthase from burkholderia pseudomallei Source: Burkholderia pseudomallei. Pseudomonas pseudomallei. Organism_taxid: 28450. Strain: 1710b. Gene: ispf, mecs, bpsl2098. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C, D, E, F (155 residues) CATH domain: 3.30.1330.50
3f0e		Crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from burkholderia pseudomallei Source: Burkholderia pseudomallei. Pseudomonas pseudomallei. Organism_taxid: 28450. Strain: 1710b. Gene: ispf, mecs, bpsl2098. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C (158 residues) CATH domain: 3.30.1330.50
3f0f		Co-crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from burkholderia pseudomallei with hydrolyzed cdp Source: Burkholderia pseudomallei. Pseudomonas pseudomallei. Organism_taxid: 28450. Strain: 1710b. Gene: ispf, mecs, bpsl2098. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C (159 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group C5P corresponds to enzyme product CMP
3f0g		Co-crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase with cmp Source: Burkholderia pseudomallei. Pseudomonas pseudomallei. Organism_taxid: 28450. Strain: 1710b. Gene: ispf, mecs, bpsl2098. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C, D, E, F (159 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group C5P corresponds to enzyme product CMP
3f6m		Crystal structure of 2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase ispf from yersinia pestis Source: Yersinia pestis. Organism_taxid: 214092. Strain: co92. Gene: ispf, y0829, ypo3360, yp_0327. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (161 residues) CATH domain: 3.30.1330.50
3fba		Crystal structure of 2c-methyl-d-erythritol 2,4-clycodiphosphate synthase complexed with ligand Source: Escherichia coli. Organism_taxid: 83333. Gene: ispf. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (158 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group C6B corresponds to enzyme product CMP
3fpi		Crystal structure of 2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase ispf complexed with cytidine triphosphate Source: Yersinia pestis. Organism_taxid: 214092. Strain: co92. Gene: ispf, y0829, ypo3360, yptb0771, yp_0327. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (161 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group CTP is 72.41% similar to enzyme product CMP
3ghz		2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from salmonella typhimurium Source: Salmonella typhimurium. Organism_taxid: 602. Strain: lt2. Gene: ispf, stm2929. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C (157 residues) CATH domain: 3.30.1330.50
3ieq		Crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from burkholderia pseudomallei with cytidine Source: Burkholderia pseudomallei. Pseudomonas pseudomallei. Organism_taxid: 28450. Strain: 1710b. Gene: ispf, mecs, bpsl2098. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C (158 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group CTN is 80.95% similar to enzyme product CMP
3iew		Crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from burkholderia pseudomallei with bound ctp and cdp Source: Burkholderia pseudomallei. Organism_taxid: 28450. Strain: 1710b. Gene: ispf, mecs, bpsl2098. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C (160 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group CDP is 84.00% similar to enzyme product CMP
3ike		Crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from burkholderia pseudomallei with cytosine Source: Burkholderia pseudomallei. Pseudomonas pseudomallei. Organism_taxid: 28450. Strain: 1710b. Gene: ispf, mecs, bpsl2098. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C (158 residues) CATH domain: 3.30.1330.50
3ikf		Crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from burkholderia pseudomallei with fol fragment 717, imidazo[2,,1-b][1,3]thiazol-6-ylmethanol Source: Burkholderia pseudomallei. Pseudomonas pseudomallei. Organism_taxid: 28450. Strain: 1710b. Gene: ispf, mecs, bpsl2098. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C (158 residues) CATH domain: 3.30.1330.50
3jvh		Crystal structure of 2c-methyl-d-erythritol-2,4-cyclodiphosphate synthase from burkholderia pseudomallei with fol fragment 8395 Source: Burkholderia pseudomallei. Pseudomonas pseudomallei. Organism_taxid: 28450. Strain: 1710b. Gene: ispf, mecs, bpsl2098. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C (158 residues) CATH domain: 3.30.1330.50
3k14		Co-crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from burkholderia pseudomallei with fol fragment 535, ethyl 3-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole-2-carboxylate Source: Burkholderia pseudomallei. Pseudomonas pseudomallei. Organism_taxid: 28450. Strain: 1710b. Gene: ispf, mecs, bpsl2098. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C (158 residues) CATH domain: 3.30.1330.50
3k2x		Crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from burkholderia pseudomallei in complex with 5'-iodo- cytosine Source: Burkholderia pseudomallei. Organism_taxid: 320372. Strain: 1710b. Gene: ispf, burps1710b_2511. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C (154 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group I5A is 72.73% similar to enzyme product CMP
3ke1		Crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from burkholderia pseudomallei in complex with a fragment- nucleoside fusion d000161829 Source: Burkholderia pseudomallei. Pseudomonas pseudomallei. Organism_taxid: 28450. Strain: 1710b. Gene: ispf, mecs, bpsl2098. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C (150 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group 829 is 53.33% similar to enzyme product CMP
3mbm		Crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from burkholderia pseudomallei with cytosine and fol fragment 717, imidazo[2,1-b][1,3]thiazol-6-ylmethanol Source: Burkholderia pseudomallei. Pseudomonas pseudomallei. Organism_taxid: 28450. Strain: 1710b. Gene: ispf, mecs, bpsl2098. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C (158 residues) CATH domain: 3.30.1330.50
3p0z		Crystal structure of 2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from burkholderia pseudomallei with cytidine and fol955, 4- (1h-imidazol)-1-yl)phenol Source: Burkholderia pseudomallei. Organism_taxid: 320372. Strain: 1710b. Gene: ispf, burps1710b_2511. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C (158 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group CTN is 80.95% similar to enzyme product CMP
3p10		Crystal structure of 2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from burkholderia pseudomallei with cytidine and fol694, 2- (thiophen-2-yl)phenyl methanol Source: Burkholderia pseudomallei. Organism_taxid: 320372. Strain: 1710b. Gene: ispf, burps1710b_2511. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C (159 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group CTN is 80.95% similar to enzyme product CMP
3q8h		Crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from burkholderia pseudomallei in complex with cytidine derivative ebsi01028 Source: Burkholderia pseudomallei. Pseudomonas pseudomallei. Organism_taxid: 28450. Strain: 1710b. Gene: ispf, mecs, bpsl2098. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C (151 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group AO9 is 50.00% similar to enzyme product CMP
3qhd		Crystal structure of 2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from burkholderia pseudomallei bound to cytidine, fol795 and fol955 Source: Burkholderia pseudomallei. Organism_taxid: 320372. Strain: 1710b. Gene: ispf, burps1710b_2511. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C (159 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group CTN is 80.95% similar to enzyme product CMP
3re3		Crystal structure of 2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from francisella tularensis Source: Francisella tularensis subsp. Tularensis. Organism_taxid: 177416. Strain: schu s4. Gene: ftt_1128, ispf. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C, D (148 residues) CATH domain: 3.30.1330.50
3t80		Crystal structure of 2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from salmonella typhimurium bound to cytidine Source: Salmonella enterica subsp. Enterica serovar typhimurium. Organism_taxid: 90371. Strain: lt2. Gene: ispf, stm2929. Expressed in: escherichia coli. Expression_system_taxid: 469008. Chains: A, B, C, D, E, F (157 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group CTN is 80.95% similar to enzyme product CMP
4c81		Ispf (plasmodium falciparum) cdp complex Source: Plasmodium falciparum. Organism_taxid: 36329. Strain: 3d7. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: gold. Other_details: synthetic gene Chain: A (156 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group CDP is 84.00% similar to enzyme product CMP
4c82		Ispf (plasmodium falciparum) unliganded structure Source: Plasmodium falciparum. Organism_taxid: 36329. Strain: 3d7. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: gold. Chain: A (156 residues) CATH domain: 3.30.1330.50
4c8e		Ispf (burkholderia cenocepacia) 2cmp complex Source: Burkholderia cenocepacia. Organism_taxid: 216591. Strain: j2315. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: gold. Other_details: genomic DNA Chains: A, B, C (161 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group C5P corresponds to enzyme product CMP
4c8g		Ispf (burkholderia cenocepacia) cmp complex Source: Burkholderia cenocepacia. Organism_taxid: 216591. Strain: j2315. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: gold. Other_details: genomic DNA Chains: A, B, C (153 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group C5P corresponds to enzyme product CMP
4c8i		Ispf (burkholderia cenocepacia) citrate complex Source: Burkholderia cenocepacia. Organism_taxid: 216591. Strain: j2315. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: gold. Other_details: genomic DNA Chains: A, B, C (149 residues) CATH domain: 3.30.1330.50
5b8f		X-ray crystal structure of a 2-c-methyl-d-erythritol 2,4- cyclodiphosphate synthase from pseudomonas aeruginosa Source: Pseudomonas aeruginosa (strain atcc 15692 / pao1 / 1c / prs 101 / lmg 12228). Organism_taxid: 208964. Strain: atcc 15692 / pao1 / 1c / prs 101 / lmg 12228. Gene: ispf, pa3627. Expressed in: escherichia coli. Expression_system_taxid: 469008. Chains: A, B, C (159 residues) CATH domain: 3.30.1330.50 Bound ligand:   Het Group C5P corresponds to enzyme product CMP
5esv		Crystal structure of broadly neutralizing antibody ch03, isolated from donor ch0219, in complex with scaffolded trimeric HIV-1 env v1v2 domain from the cladE C superinfecting strain of donor cap256. Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: expi293. Gene: igkc. Haemophilus influenzae, human immunodeficiency virus 1, haemophilus influenzae (strain atcc 51907 / dsm 11121 / Chains: E, F, G (176 residues) Bound ligand:   Het Group NAG is 52.17% similar to enzyme product CMP
5esz		Crystal structure of broadly neutralizing antibody ch04, isolated from donor ch0219, in complex with scaffolded trimeric HIV-1 env v1v2 domain from the clade ae strain a244 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ighg1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: expi293. Gene: igkc. Haemophilus influenzae, human immunodeficiency Chains: C, G (163 residues) Bound ligand:   Het Group NAG is 52.17% similar to enzyme product CMP
5iwx		Crystal structure of 2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from bacillus subtitis Source: Bacillus subtilis (strain 168). Organism_taxid: 224308. Strain: 168. Gene: ispf, yacn, bsu00910. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C, D, E, F (158 residues)
5iwy		Crystal structure of 2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from bacillus subtitis complexed with cmp and mg2+ Source: Bacillus subtilis (strain 168). Organism_taxid: 224308. Strain: 168. Gene: ispf, yacn, bsu00910. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C, D, E, F (158 residues) Bound ligand:   Het Group C5P corresponds to enzyme product CMP
5l03		Crystal structure of 2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from burkholderia pseudomallei bound to l-tryptophan hydroxamate Source: Burkholderia pseudomallei. Organism_taxid: 28450. Gene: ispf, dp46_3085, ers012314_03919, sy87_14040. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B, C (158 residues)
5l12		Crystal structure of 2c-methyl-d-erythritol 2,4-clycodiphosphate synthase from burkholderia pseudomallei double mutant Source: Burkholderia pseudomallei (strain 1106a). Organism_taxid: 357348. Strain: 1106a. Gene: ispf, burps1106a_2400. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B, C (157 residues)
6mwf		Crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase (ispf) burkholderia pseudomallei in complex with ligand hgn- 0459 Source: Burkholderia pseudomallei (strain 1710b). Organism_taxid: 320372. Strain: 1710b. Gene: ispf, burps1710b_2511. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B, C (159 residues)
6mwi		Crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase (ispf) burkholderia pseudomallei in complex with ligand hgn- 0456 Source: Burkholderia pseudomallei (strain 1710b). Organism_taxid: 320372. Strain: 1710b. Gene: ispf, burps1710b_2511. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B, C (159 residues)
6mwj		Crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase (ispf) burkholderia pseudomallei in complex with ligand hgn- 0863 Source: Burkholderia pseudomallei (strain 1710b). Organism_taxid: 320372. Strain: 1710b. Gene: ispf, burps1710b_2511. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B, C (160 residues)
6mwk		Crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase (ispf) burkholderia pseudomallei in complex with ligand hgn- 0883 Source: Burkholderia pseudomallei (strain 1710b). Organism_taxid: 320372. Strain: 1710b. Gene: ispf, burps1710b_2511. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B, C (160 residues)
6nmo		Crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase (ispf) burkholderia pseudomallei in complex with ligand sr-4 Source: Burkholderia pseudomallei (strain 1710b). Organism_taxid: 320372. Strain: 1710b. Gene: ispf, burps1710b_2511. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 469008. Chains: A, B, C (159 residues)
6v3m		Crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase (ispf) burkholderia pseudomallei in compomplex with ligand hgn-0961 (bsi110840) Source: Burkholderia pseudomallei (strain 1710b). Organism_taxid: 320372. Strain: 1710b. Gene: ispf, burps1710b_2511. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768. Chains: A, B, C (160 residues)
8xhu		Crystal structure of helicobacter pylori ispdf Source: Helicobacter pylori 26695. Organism_taxid: 85962. Gene: ispdf, hp_1020. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008 Chains: A, B, C (354 residues)
8xkf		Crystal structure of helicobacter pylori ispdf with substrate ctp Source: Helicobacter pylori 26695. Organism_taxid: 85962. Gene: ispdf, hp_1020. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008 Chains: A, B, C, D, E, F (370 residues) Bound ligand:   Het Group CTP is 72.41% similar to enzyme product CMP