_EC 4.2.1.19 imidazoleglycerol-phosphate dehydratase. 39 PDB entries  
EC 4.-.-.- Lyases. [10,261 PDB entries]
EC 4.2.-.- Carbon-oxygen lyases. [5,844 PDB entries]
EC 4.2.1.- Hydro-lyases. [4,244 PDB entries]
EC 4.2.1.19 imidazoleglycerol-phosphate dehydratase. [39 PDB entries]
1rhy

Pathway: Histidine Biosynthesis (late stages)
Reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2- oxopropyl phosphate + H2O.
 


D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
 =
3-(imidazol-4-yl)-2- oxopropyl phosphate
 + H2O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 39 PDB entries in enzyme class E.C.4.2.1.19

  PDB code Protein
1rhy
Crystal structure of imidazole glycerol phosphate dehydratase
Source: Filobasidiella neoformans. Organism_taxid: 5207. Gene: his3. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (180 residues) CATH domains: 3.30.230.40 3.30.230.40
Bound ligand:   Het Group GOL is 40.00% similar to enzyme reactant D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
2ae8
Crystal structure of imidazoleglycerol-phosphate dehydratase from staphylococcus aureus subsp. Aureus n315
Source: Staphylococcus aureus subsp. Aureus. Organism_taxid: 158879. Strain: n315. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (171 residues) CATH domains: 3.30.230.40 3.30.230.40
2f1d
X-ray structure of imidazoleglycerol-phosphate dehydratase
Source: Arabidopsis thaliana. Thale cress. Organism_taxid: 3702. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P (183 residues) CATH domains: 3.30.230.40 3.30.230.40
2fpr
Crystal structure the n-terminal domain of e. Coli hisb. Apo mg model.
Source: Escherichia coli. Organism_taxid: 83334. Strain: o157:h7. Gene: hisb. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (156 residues) CATH domain: 3.40.50.1000
2fps
Crystal structure of the n-terminal domain of e.Coli hisb- apo ca model.
Source: Escherichia coli. Organism_taxid: 83334. Strain: o157:h7. Gene: hisb. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (158 residues) CATH domain: 3.40.50.1000
2fpu
Crystal structure of the n-terminal domain of e.Coli hisb- complex with histidinol
Source: Escherichia coli. Organism_taxid: 83334. Strain: o157:h7. Gene: hisb. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (158 residues) CATH domain: 3.40.50.1000
Bound ligand:   Het Group HSO is 60.00% similar to enzyme product 3-(imidazol-4-yl)-2-oxopropyl phosphate
2fpw
Crystal structure of the n-terminal domain of e.Coli hisb- phosphoaspartate intermediate.
Source: Escherichia coli. Organism_taxid: 83334. Strain: o157:h7. Gene: hisb. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (156 residues) CATH domain: 3.40.50.1000
2fpx
Crystal structure of the n-terminal domain of e.Coli hisb- sulfate complex.
Source: Escherichia coli. Organism_taxid: 83334. Strain: o157:h7. Gene: hisb. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (156 residues) CATH domain: 3.40.50.1000
4gqu
Crystal structure of hisb from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: hisb, mt1637, mtcy336.03c, rv1601. Expressed in: mycobacterium smegmatis. Expression_system_taxid: 1772.
Chain: A (191 residues) CATH domains: 3.30.230.40 3.30.230.40
4mu0
The structure of wt a. Thaliana igpd2 in complex with mn2+ and 1,2,4- triazole at 1.3 a resolution
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: at4g14910, dl3495c, hisn5b. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (185 residues) CATH domains: 3.30.230.40 3.30.230.40
4mu1
The structure of wt a. Thaliana igpd2 in complex with mn2+, imidazole, and sulfate at 1.5 a resolution
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: at4g14910, dl3495c, hisn5b. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (185 residues) CATH domains: 3.30.230.40 3.30.230.40
4mu3
The form a structure of an e21q catalytic mutant of a. Thaliana igpd2 in complex with mn2+ and a mixture of its substrate, 2r3s-igp, and an inhibitor, 2s3s-igp, to 1.12 a resolution
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: at4g14910, dl3495c, hisn5b. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (186 residues) CATH domains: 3.30.230.40 3.30.230.40
Bound ligand:   Het Group IG2 corresponds to enzyme reactant D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
4mu4
The form b structure of an e21q catalytic mutant of a. Thaliana igpd2 in complex with mn2+ and its substrate, 2r3s-igp, to 1.41 a resolution
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: at4g14910, dl3495c, hisn5b. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (199 residues) CATH domains: 3.30.230.40 3.30.230.40
Bound ligand:   Het Group IYP corresponds to enzyme reactant D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
4qnj
The structure of wt a. Thaliana igpd2 in complex with mn2+ and formate at 1.3a resolution
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: at4g14910, dl3495c, hisn5b. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (184 residues) CATH domains: 3.30.230.40 3.30.230.40
4qnk
The structure of wt a. Thaliana igpd2 in complex with mn2+ and phosphate
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: at4g14910, dl3495c, hisn5b. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F, G, H (185 residues) CATH domains: 3.30.230.40 3.30.230.40
5dnl
Crystal structure of igpd from pyrococcus furiosus in complex with (s)-c348
Source: Pyrococcus furiosus. Organism_taxid: 2261. Gene: hisb, pf1660. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, C, B (176 residues) CATH domains: 3.30.230.40 3.30.230.40
5dnx
Crystal structure of igpd from pyrococcus furiosus in complex with (r)-c348
Source: Pyrococcus furiosus. Organism_taxid: 2261. Gene: hisb, pf1660. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, C, B (176 residues) CATH domains: 3.30.230.40 3.30.230.40
Bound ligand:   Het Group 5LD is 40.00% similar to enzyme reactant D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
5ekw
A. Thaliana igpd2 in complex with the racemate of the triazole- phosphonate inhibitor, c348
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: hisn5b, at4g14910, dl3495c. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (194 residues) CATH domains: 3.30.230.40 3.30.230.40
Bound ligand:   Het Group 5LD is 40.00% similar to enzyme reactant D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
5el9
A. Thaliana igpd2 in complex with the triazole-phosphonate inhibitor, (s)-c348, to 1.1a resolution
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: hisn5b, at4g14910, dl3495c. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (199 residues) CATH domains: 3.30.230.40 3.30.230.40
5elw
A. Thaliana igpd2 in complex with the triazole-phosphonate inhibitor, (r)-c348, to 1.36a resolution
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: hisn5b, at4g14910, dl3495c. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (199 residues) CATH domains: 3.30.230.40 3.30.230.40
Bound ligand:   Het Group 5LD is 40.00% similar to enzyme reactant D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
5xds
Crystal structure of mycobacterium tuberculosis hisb bound with an inhibitor
Source: Mycobacterium tuberculosis (strain atcc 25618 / h37rv). Organism_taxid: 83332. Strain: atcc 25618 / h37rv. Gene: hisb, rv1601, mtcy336.03c. Expressed in: mycobacterium smegmatis. Expression_system_taxid: 1772
Chain: A (191 residues)
Bound ligand:   Het Group 83O is 47.06% similar to enzyme product 3-(imidazol-4-yl)-2-oxopropyl phosphate
5zqn
Crystal structure of mycobacterium tuberculosis hisb in complex with a ligand
Source: Mycobacterium tuberculosis h37rv. Organism_taxid: 83332. Strain: h37rv. Gene: hisb, rv1601, mtcy336.03c. Expressed in: mycobacterium smegmatis. Expression_system_taxid: 1772
Chain: A (191 residues)
Bound ligand:   Het Group IYP corresponds to enzyme reactant D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
6ezj
Imidazoleglycerol-phosphate dehydratase
Source: Arabidopsis thaliana. Thale cress. Organism_taxid: 3702. Gene: hisn5b, at4g14910, dl3495c. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X (185 residues)
Bound ligand:   Het Group 5LD is 40.00% similar to enzyme reactant D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
6ezm
Imidazoleglycerol-phosphate dehydratase from saccharomyces cerevisiae
Source: Saccharomyces cerevisiae (strain atcc 204508 / s288c). Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Gene: his3, yor202w. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: U, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, V, W, X (212 residues)
Bound ligand:   Het Group 5LD is 40.00% similar to enzyme reactant D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
6fwh
Acanthamoeba igpd in complex with r-c348 to 1.7a resolution
Source: Acanthamoeba castellanii. Amoeba. Organism_taxid: 5755. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
Chains: A, B, C, D, E, F, G, H, I, J, K, L (196 residues)
Bound ligand:   Het Group 5LD is 40.00% similar to enzyme reactant D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
6khh
Crystal structure of hisb from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: hisb, ers007670_03574, ers007672_02943, ers007679_00418, ers007681_01092, ers023446_00531, ers024213_01935, ers027646_00106. Expressed in: mycolicibacterium smegmatis. Expression_system_taxid: 1772
Chain: A (191 residues)
6yjh
Crystal structure of imidazole glycerol phosphate dehydratase from mycobacterium tuberculosis at 1.61 a resolution
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (191 residues)
7ddv
Crystal structure of m.Tuberculosis imidazole glycerol phosphate dehydratase in complex with an inhibitor
Source: Mycobacterium tuberculosis (strain atcc 25618 / h37rv). Organism_taxid: 83332. Strain: atcc 25618 / h37rv. Gene: hisb, rv1601, mtcy336.03c. Expressed in: mycolicibacterium smegmatis. Expression_system_taxid: 1772
Chain: A (190 residues)
Bound ligand:   Het Group GOL is 40.00% similar to enzyme reactant D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
7dnq
Crystal structure of m.Tuberculosis imidazole glycerol phosphate dehydratase in complex with an inhibitor
Source: Mycobacterium tuberculosis (strain atcc 25618 / h37rv). Organism_taxid: 83332. Strain: atcc 25618 / h37rv. Gene: hisb, rv1601, mtcy336.03c. Expressed in: mycolicibacterium smegmatis. Expression_system_taxid: 1772
Chain: A (190 residues)
7fcy
Crystal structure of m.Tuberculosis imidazole glycerol phosphate dehydratase in complex with an inhibitor
Source: Mycobacterium tuberculosis (strain atcc 25618 / h37rv). Organism_taxid: 83332. Strain: atcc 25618 / h37rv. Gene: hisb, rv1601, mtcy336.03c. Expressed in: mycolicibacterium smegmatis. Expression_system_taxid: 1772
Chain: A (190 residues)
7oj5
Cryo-em structure of medicago truncatula hisn5 protein
Source: Medicago truncatula. Barrel medic, medicago tribuloides. Organism_taxid: 3880. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, V, W, X, Y (184 residues)
8qav
Medicago truncatula hisn5 (igpd) in complex with mn and ig2
Source: Medicago truncatula. Barrel medic. Organism_taxid: 3880. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, V, W, X, Y (184 residues)
Bound ligand:   Het Group IG2 corresponds to enzyme reactant D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
8qaw
Medicago truncatula hisn5 (igpd) in complex with mn, imd, edo, fmt, gol and trs
Source: Medicago truncatula. Barrel medic. Organism_taxid: 3880. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H (185 residues)
8qax
Medicago truncatula hisn5 (igpd) in complex with mn, fmt, gol and trs
Source: Medicago truncatula. Barrel medic. Organism_taxid: 3880. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (185 residues)
Bound ligand:   Het Group GOL is 40.00% similar to enzyme reactant D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
8qay
Medicago truncatula hisn5 (igpd) in complex with mn, fmt, act, cit, edo, so4
Source: Medicago truncatula. Barrel medic. Organism_taxid: 3880. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H (185 residues)
8wmp
Crystal structure of mutant hisb from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: hisb. Expressed in: mycolicibacterium smegmatis. Expression_system_taxid: 1772
Chain: A (191 residues)
9m2p
Imidazole glycerol phosphate dehydratase from mycobacterium tuberculosis, apo structure
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: hisb, rv1601, mtcy336.03c. Expressed in: mycolicibacterium smegmatis. Expression_system_taxid: 1772.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X (190 residues)
9m2q
Imidazole glycerol phosphate dehydratase from mycobacterium tuberculosis, in complex with aminotriazole
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: hisb, rv1601, mtcy336.03c. Expressed in: mycolicibacterium smegmatis. Expression_system_taxid: 1772.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X (190 residues)
9m2r
Imidazole glycerol phosphate dehydratase from mycobacterium tuberculosis, apo structure
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: hisb, rv1601, mtcy336.03c. Expressed in: mycolicibacterium smegmatis. Expression_system_taxid: 1772.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X (190 residues)