_EC 3.4.24.65 macrophage elastase. 85 PDB entries  
EC 3.-.-.- Hydrolases. [51,812 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptidases). [15,795 PDB entries]
EC 3.4.24.- Metalloendopeptidases. [1,122 PDB entries]
EC 3.4.24.65 macrophage elastase. [85 PDB entries]
1jiz

Reaction: Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin.
Other name(s): matrix metalloproteinase 12. metalloelastase.
Comments: Belongs to peptidase family M10B.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 85 PDB entries in enzyme class E.C.3.4.24.65

  PDB code Protein
1jiz
Crystal structure analysis of human macrophage elastase mmp-12
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (166 residues) CATH domain: 3.40.390.10
1jk3
Crystal structure of human mmp-12 (macrophage elastase) at true atomic resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (158 residues) CATH domain: 3.40.390.10
1os2
Ternary enzyme-product-inhibitor complexes of human mmp12
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12 or hme. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F (165 residues) CATH domain: 3.40.390.10
1os9
Binary enzyme-product complexes of human mmp12
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12 or hme. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F (165 residues) CATH domain: 3.40.390.10
1rmz
Crystal structure of the catalytic domain of human mmp12 complexed with the inhibitor nngh at 1.3 a resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (159 residues) CATH domain: 3.40.390.10
1ros
Crystal structure of mmp-12 complexed to 2-(1,3-dioxo-1,3-dihydro-2h- isoindol-2-yl)ethyl-4-(4-ethoxy[1,1-biphenyl]-4-yl)-4-oxobutanoic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (159 residues) CATH domain: 3.40.390.10
1utt
Crystal structure of mmp-12 complexed to 2-(1,3-dioxo-1,3-dihydro-2h- isoindol-2-yl)ethyl-4-(4-ethoxy[1,1-biphenyl]-4-yl)-4-oxobutanoic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (159 residues) CATH domain: 3.40.390.10
1utz
Crystal structure of mmp-12 complexed to (2r)-3-({[4-[(pyridin-4-yl) phenyl]-thien-2-yl}carboxamido)(phenyl)propanoic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (159 residues) CATH domain: 3.40.390.10
1y93
Crystal structure of the catalytic domain of human mmp12 complexed with acetohydroxamic acid at atomic resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (158 residues) CATH domain: 3.40.390.10
1ycm
Solution structure of matrix metalloproteinase 12 (mmp12) in the presence of n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid (nngh)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (159 residues) CATH domain: 3.40.390.10
1z3j
Solution structure of mmp12 in the presence of n-isobutyl-n-4- methoxyphenylsulfonyl]glycyl hydroxamic acid (nngh)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.390.10
2hu6
Crystal structure of human mmp-12 in complex with acetohydroxamic acid and a bicyclic inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (158 residues) CATH domain: 3.40.390.10
2jxy
Solution structure of the hemopexin-like domain of mmp12
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (194 residues) CATH domain: 2.110.10.10
2k2g
Solution structure of the wild-type catalytic domain of human matrix metalloproteinase 12 (mmp-12) in complex with a tight-binding inhibitor
Source: Homo sapiens. Human. Gene: mmp12, hme. Expressed in: escherichia coli.
Chain: A (165 residues) CATH domain: 3.40.390.10
2k9c
Paramagnetic shifts in solid-state nmr of proteins to elicit structural information
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (152 residues) CATH domain: 3.40.390.10
2krj
High-resolution solid-state nmr structure of a 17.6 kda protein
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (152 residues) CATH domain: 3.40.390.10
2mlr
Membrane bilayer complex with matrix metalloproteinase-12 at its alpha-face
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (164 residues) CATH domain: 3.40.390.10
2mls
Membrane bilayer complex with matrix metalloproteinase-12 at its beta- face
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (164 residues) CATH domain: 3.40.390.10
2n8r
Productive complex between mmp-12 and synthetic triple-helical collagen, revealed through paramagnetic nmr
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
Chain: A (164 residues) CATH domain: 3.40.390.10
2oxu
Uninhibited form of human mmp-12
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (158 residues) CATH domain: 3.40.390.10
2oxw
Human mmp-12 complexed with the peptide iag
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes
Chain: A (158 residues) CATH domain: 3.40.390.10
2oxz
Human mmp-12 in complex with two peptides pqg and iag
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Synthetic: yes
Chain: A (158 residues) CATH domain: 3.40.390.10
2poj
Nmr solution structure of the inhibitor-free state of macrophage metalloelastase (mmp-12)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (164 residues) CATH domain: 3.40.390.10
2w0d
Does a fast nuclear magnetic resonance spectroscopy- and x-ray crystallography hybrid approach provide reliable structural information of ligand-protein complexes? a case study of metalloproteinases.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (159 residues) CATH domain: 3.40.390.10
2wo8
Mmp12 complex with a beta hydroxy carboxylic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: macrophage. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (164 residues) CATH domain: 3.40.390.10
2wo9
Mmp12 complex with a beta hydroxy carboxylic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: macrophage. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (162 residues) CATH domain: 3.40.390.10
2woa
Mmp12 complex with a beta hydroxy carboxylic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: macrophage. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (163 residues) CATH domain: 3.40.390.10
2z2d
Solution structure of human macrophage elastase (mmp-12) catalytic domain complexed with a gamma-keto butanoic acid inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (158 residues) CATH domain: 3.40.390.10
3ba0
Crystal structure of full-length human mmp-12
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (365 residues) CATH domains: 3.40.390.10 2.110.10.10
3ehx
Crystal structure of the catalytic domain of human mmp12 complexed with the inhibitor (r)-2-(biphenyl-4-ylsulfonamido)-4-methylpentanoic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: hme. Gene: mmp12. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (158 residues) CATH domain: 3.40.390.10
3ehy
Crystal structure of the catalytic domain of human mmp12 complexed with the inhibitor (r)-2-(4-methoxyphenylsulfonamido)propanoic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: hme. Gene: mmp12. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (158 residues) CATH domain: 3.40.390.10
3f15
Crystal structure of the catalytic domain of human mmp12 complexed with the inhibitor (s)-n-(2,3-dihydroxypropyl)-4-methoxy-n-(2- nitroso-2-oxoethyl)benzenesulfonamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hme, mmp12. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.40.390.10
3f16
Crystal structure of the catalytic domain of human mmp12 complexed with the inhibitor (r)-n-(3-hydroxy-1-nitroso-1-oxopropan-2-yl)-4- methoxybenzenesulfonamide
Source: Homo sapiens. Organism_taxid: 9606. Gene: hme, mmp12. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.40.390.10
3f17
Crystal structure of the catalytic domain of human mmp12 complexed with the inhibitor n-(2-nitroso-2-oxoethyl)biphenyl-4-sulfonamide
Source: Homo sapiens. Organism_taxid: 9606. Gene: hme, mmp12. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.40.390.10
3f18
Crystal structure of the catalytic domain of human mmp12 complexed with the inhibitor 4-fluoro-n-(2-hydroxyethyl)-n-(2-nitroso-2- oxoethyl)benzenesulfonamide
Source: Homo sapiens. Organism_taxid: 9606. Gene: hme, mmp12. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.40.390.10
3f19
Crystal structure of the catalytic domain of human mmp12 complexed with the inhibitor 4-fluoro-n-(2-nitroso-2-oxoethyl) benzenesulfonamide
Source: Homo sapiens. Organism_taxid: 9606. Gene: hme, mmp12. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.40.390.10
3f1a
Crystal structure of the catalytic domain of human mmp12 complexed with the inhibitor n-(2-nitroso-2-oxoethyl)benzenesulfonamide
Source: Homo sapiens. Organism_taxid: 9606. Gene: hme, mmp12. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.40.390.10
3lik
Human mmp12 in complex with non-zinc chelating inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.390.10
3lil
Human mmp12 in complex with non-zinc chelating inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.390.10
3lir
Human mmp12 in complex with non-zinc chelating inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.390.10
3ljg
Human mmp12 in complex with non-zinc chelating inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.390.10
3lk8
Crystal structure of the catalytic domain of human mmp12 complexed with the inhibitor paramethoxy-sulfonyl-glycine hydroxamate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hme, mmp12. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.40.390.10
3lka
Catalytic domain of human mmp-12 complexed with hydroxamic acid and paramethoxy-sulfonyl amide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hme, mmp12. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (158 residues) CATH domain: 3.40.390.10
3n2u
Crystal structure of the catalytic domain of human mmp12 complexed with the inhibitor n-hydroxy-2-(4-methoxy-n(2-(3,4,5-trihydroxy-6- (hydroxymethyl)tetrahydro-2h-pyran-2-yloxy)ethyl)phenylsulfonamido) acetamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.40.390.10
3n2v
Crystal structure of the catalytic domain of human mmp12 complexed with the inhibitor n-hydroxy-2-(n-hydroxyethyl)biphenyl-4- ylsulfonamido)acetamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.40.390.10
3nx7
Crystal structure of the catalytic domain of human mmp12 complexed with the inhibitor n-hydroxy-2-(n-(2-hydroxyethyl)4- methoxyphenylsulfonamido)acetamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hme, mmp12. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.40.390.10
3rts
Human mmp-12 catalytic domain in complex with N -Hydroxy-2-(2- phenylethylsulfonamido)acetamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (158 residues) CATH domain: 3.40.390.10
3rtt
Human mmp-12 catalytic domain in complex with (R)-n -Hydroxy-1- (phenethylsulfonyl)pyrrolidine-2-carboxamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (158 residues) CATH domain: 3.40.390.10
3ts4
Human mmp12 in complex with l-glutamate motif inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hme, mmp12. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.390.10
3tsk
Human mmp12 in complex with l-glutamate motif inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hme, mmp12. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.390.10
3uvc
Mmp12 in a complex with the dimeric adduct: 5-(5-phenylhydantoin)-5- phenylhydantoin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: 4321, hme, mmp12. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (158 residues) CATH domain: 3.40.390.10
4efs
Human mmp12 in complex with l-glutamate motif inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hme, mmp12. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.390.10
4gql
Crystal structure of the catalytic domain of human mmp12 in complex with selective phosphinic inhibitor rxp470.1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hme, mmp12. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.390.10
4gr0
Crystal structure of the catalytic domain of human mmp12 in complex with selective phosphinic inhibitor rxp470b
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hme, mmp12. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (159 residues) CATH domain: 3.40.390.10
4gr3
Crystal structure of the catalytic domain of human mmp12 in complex with selective phosphinic inhibitor rxp470a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hme, mmp12. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (159 residues) CATH domain: 3.40.390.10
4gr8
Crystal structure of the catalytic domain of human mmp12 in complex with selective phosphinic inhibitor rxp470c
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hme, mmp12. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (152 residues) CATH domain: 3.40.390.10
4guy
Human mmp12 catalytic domain in complex with N -Hydroxy-2-(2-(4- methoxyphenyl)ethylsulfonamido)acetamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (158 residues) CATH domain: 3.40.390.10
4h30
Crystal structure of the catalytic domain of mmp-12 in complex with a twin inhibitor.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hme, mmp12. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (159 residues) CATH domain: 3.40.390.10
4h49
Crystal structure of the catalytic domain of mmp-12 in complex with a twin inhibitor.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hme, mmp12. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D (159 residues) CATH domain: 3.40.390.10
4h76
Crystal structure of the catalytic domain of human mmp12 in complex with a broad spectrum hydroxamate inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hme, mmp12. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (159 residues) CATH domain: 3.40.390.10
4h84
Crystal structure of the catalytic domain of human mmp12 in complex with a selective carboxylate based inhibitor.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hme, mmp12. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (159 residues) CATH domain: 3.40.390.10
4i03
Human mmp12 in complex with a peg-linked bifunctional l-glutamate motif inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: escherichia coli. Gene: hme, mmp12. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (159 residues) CATH domain: 3.40.390.10
4ijo
Unraveling hidden allosteric regulatory sites in structurally homologues metalloproteases
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.40.390.10
5cxa
Crystal structure of the catalytic domain of human mmp12 in complex with a carboxylate inhibitor related to rxp470
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (159 residues) CATH domain: 3.40.390.10
5czm
Crystal structure of a mutated catalytic domain of human mmp12 in complex with rxp470
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (159 residues) CATH domain: 3.40.390.10
5d2b
Crystal structure of a mutated catalytic domain of human mmp12 in complex with an hydroxamate analogue of rxp470
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (159 residues) CATH domain: 3.40.390.10
5d3c
Crystal structure of a double mutant catalytic domain of human mmp12 in complex with an hydroxamate analogue of rxp470
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (159 residues) CATH domain: 3.40.390.10
5i0l
Crystal structure of the catalytic domain of mmp-12 in complex with a selective sugar-conjugated arylsulfonamide carboxylate water-soluble inhibitor (dc27).
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: macrophage. Gene: mmp12, hme. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star
Chains: A, B (158 residues) CATH domain: 3.40.390.10
5i2z
Crystal structure of the catalytic domain of mmp-12 in complex with a selective sugar-conjugated triazole-linked carboxylate chelating water-soluble inhibitor (dc24).
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: macrophage. Gene: mmp12, hme. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star
Chains: A, B, C, D (157 residues) CATH domain: 3.40.390.10
5i3m
Crystal structure of the catalytic domain of mmp-12 in complex with a selective sugar-conjugated thiourea-linked carboxylate zinc-chelator water-soluble inhibitor (dc31).
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: macrophage. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (157 residues) CATH domain: 3.40.390.10
5i43
Crystal structure of the catalytic domain of mmp-12 in complex with a selective sugar-conjugated triazole-linked carboxylate chelator water-soluble inhibitor (dc32).
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: macrophage. Gene: mmp12, hme. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star
Chains: A, B, C, D (157 residues) CATH domain: 3.40.390.10
5i4o
Crystal structure of the catalytic domain of mmp-12 in complex with a selective sugar-conjugated triazole-linked carboxylate zinc-chelator water-soluble inhibitor (dc28).
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: macrophage. Gene: mmp12, hme. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star
Chains: A, B, C, D (156 residues) CATH domain: 3.40.390.10
5l79
Crystal structure of mmp12 in complex with rxp470.1 conjugated with fluorophore cy5,5 in space group p21212.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (159 residues) CATH domain: 3.40.390.10
5l7f
Crystal structure of mmp12 mutant k421a in complex with rxp470.1 conjugated with fluorophore cy5,5 in space group p21.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (158 residues) CATH domain: 3.40.390.10
5lab
Crystal structure of the catalytic domain of human mmp12 complexed with the inhibitor nngh
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
Chain: A (159 residues) CATH domain: 3.40.390.10
5n5j
Human mmp12 in complex with 3-(5-(1,2-dithiolan-3-yl)pentanamido) propane-1-sulfonate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (158 residues)
5n5k
Human catalytic mmp-12 in complex with 5-(1,2-dithiolan-3-yl)-n-(3- hydroxypropyl)pentanamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (156 residues)
6ekn
Crystal structure of mmp12 in complex with inhibitor be7.
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: macrophage. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (159 residues)
6ela
Crystal structure of mmp12 in complex with inhibitor be4.
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: macrophage. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (157 residues)
6enm
Crystal structure of mmp12 in complex with hydroxamate inhibitor lp168.
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: macrophage. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (152 residues)
6eox
Crystal structure of mmp12 in complex with carboxylic inhibitor lp165.
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: macrophage. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (158 residues)
6rd0
Human mmp12 catalytic domain in complex with ap280
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (159 residues)
6rly
Human mmp12 (catalytic domain) in complex with ap316
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (159 residues)
7ovy
Crystal structure of a dimeric based inhibitor jg34 in complex with the mmp-12 catalytic domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (159 residues)
8b2n
Potempin a (pota) from tannerella forsythia in complex with the catalytic domain of human mmp-12
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp12, hme. Expressed in: escherichia coli. Expression_system_taxid: 562. Tannerella forsythia. Organism_taxid: 28112. Gene: cli86_08900.
Chains: A, C (158 residues)