_EC 3.4.24.17 stromelysin 1.

44 PDB entries

EC 3.-.-.- Hydrolases. [51,952 PDB entries] EC 3.4.-.- Acting on peptide bonds (peptidases). [15,916 PDB entries] EC 3.4.24.- Metalloendopeptidases. [1,124 PDB entries] EC 3.4.24.17 stromelysin 1. [44 PDB entries]

1b3d

Reaction:		Preferential cleavage where P1', P2' and P3' are hydrophobic residues.
Other name(s):		matrix metalloproteinase 3. proteoglycanase. transin.
Comments:		Extracellular endopeptidase of vertebrate tissues. Degradation of proteoglycans, fibronectin, collagen type Iii, iv, V and ix and activates procollagenase. Belongs to peptidase family M10B.
Links:		[IntEnz]   [ExPASy]   [KEGG]

There are 44 PDB entries in enzyme class E.C.3.4.24.17

PDB code		Protein
1b3d		Stromelysin-1 Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B (169 residues) CATH domain: 3.40.390.10
1b8y		X-ray structure of human stromelysin catalytic domain complexed with non-peptide inhibitors: implications for inhibitor selectivity Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (167 residues) CATH domain: 3.40.390.10
1biw		Design and synthesis of conformationally-constrained mmp inhibitors Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B (169 residues) CATH domain: 3.40.390.10
1bm6		Solution structure of the catalytic domain of human stromelysin-1 complexed to a potent non-peptidic inhibitor, nmr, 20 structures Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chain: A (173 residues) CATH domain: 3.40.390.10
1bqo		Discovery of potent, achiral matrix metalloproteinase inhibitors Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B (169 residues) CATH domain: 3.40.390.10
1c3i		Human stromelysin-1 catalytic domain complexed with ro-26-2812 Source: Homo sapiens. Human. Organism_taxid: 9606 Chains: A, B (170 residues) CATH domain: 3.40.390.10
1c8t		Human stromelysin-1 (e202q) catalytic domain complexed with ro-26-2812 Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: gigival fibroblasts. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B (167 residues) CATH domain: 3.40.390.10
1caq		X-ray structure of human stromelysin catalytic domain complexes with non-peptide inhibitors: implication for inhibitor selectivity Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: fibroblast. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (168 residues) CATH domain: 3.40.390.10
1ciz		X-ray structure of human stromelysin catalytic domain complexes with non-peptide inhibitors: implication for inhibitor selectivity Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: fibroblast. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (168 residues) CATH domain: 3.40.390.10
1cqr		Crystal structure of the stromelysin catalytic domain at 2.0 a resolution Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B (169 residues) CATH domain: 3.40.390.10
1d5j		Crystal structure of mmp3 complexed with a thiazepine based inhibitor. Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008 Chains: A, B (169 residues) CATH domain: 3.40.390.10
1d7x		Crystal structure of mmp3 complexed with a modified proline scaffold based inhibitor. Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: fibroblast. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B (169 residues) CATH domain: 3.40.390.10
1d8f		Crystal structure of mmp3 complexed with a piperazine based inhibitor. Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: fibroblast. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B (169 residues) CATH domain: 3.40.390.10
1d8m		Crystal structure of mmp3 complexed with a heterocycle-based inhibitor Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: fibroblast. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B (169 residues) CATH domain: 3.40.390.10
1g05		Heterocycle-based mmp inhibitor with p2'substituents Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: fibroblast. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B (166 residues) CATH domain: 3.40.390.10
1g49		A carboxylic acid based inhibitor in complex with mmp3 Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: fibroblast. Gene: mmp3. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B (169 residues) CATH domain: 3.40.390.10
1g4k		X-ray structure of a novel matrix metalloproteinase inhibitor complexed to stromelysin Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B, C (168 residues) CATH domain: 3.40.390.10
1hfs		Crystal structure of the catalytic domain of human fibroblast stromelysin-1 inhibited with the n-carboxy-alkyl inhibitor l-764,004 Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (160 residues) CATH domain: 3.40.390.10
1hy7		A carboxylic acid based inhibitor in complex with mmp3 Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: fibroblast. Gene: mmp3. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B (162 residues) CATH domain: 3.40.390.10
1oo9		Orientation in solution of mmp-3 catalytic domain and n-timp-1 from residual dipolar couplings Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp3 or stmy1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: timp1 or timp or clgi. Chain: A (168 residues) CATH domain: 3.40.390.10
1qia		Crystal structure of stromelysin catalytic domain Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B, C, D (162 residues) CATH domain: 3.40.390.10
1qic		Crystal structure of stromelysin catalytic domain Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B, C, D (161 residues) CATH domain: 3.40.390.10
1slm		Crystal structure of fibroblast stromelysin-1: thE C-truncated human proenzyme Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: fibroblast. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (226 residues) CATH domain: 3.40.390.10
1sln		Crystal structure of the catalytic domain of human fibroblast stromelysin-1 inhibited with the n-carboxy-alkyl inhibitor l-702,842 Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: fibroblast. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (168 residues) CATH domain: 3.40.390.10
1uea		Mmp-3/timp-1 complex Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: substitution of met by selenomet. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_variant: cho. Chains: A, C (168 residues) CATH domain: 3.40.390.10
1ums		Stromelysin-1 catalytic domain with hydrophobic inhibitor bound, ph 7.0, 32oc, 20 mm cacl2, 15% acetonitrile; nmr ensemble of 20 structures Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: human stromelysin-1 catalytic. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: induction by m13 with t7 RNA polymerase Chain: A (166 residues) CATH domain: 3.40.390.10
1umt		Stromelysin-1 catalytic domain with hydrophobic inhibitor bound, ph 7.0, 32oc, 20 mm cacl2, 15% acetonitrile; nmr average of 20 structures minimized with restraints Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: human stromelysin-1 catalytic. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: induction by m13 with t7 RNA polymerase Chain: A (166 residues) CATH domain: 3.40.390.10
1usn		Crystal structure of the catalytic domain of human fibroblast stromelysin-1 inhibited with thiadiazole inhibitor pnu-142372 Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: fibroblast. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Chain: A (165 residues) CATH domain: 3.40.390.10
2d1o		Stromelysin-1 (mmp-3) complexed to a hydroxamic acid inhibitor Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B (171 residues) CATH domain: 3.40.390.10
2jnp		Solution structure of matrix metalloproteinase 3 (mmp-3) in the presence of n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid (nngh) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp3, stmy1. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (161 residues) CATH domain: 3.40.390.10
2jt5		Solution structure of matrix metalloproteinase 3 (mmp-3) in the presence of n-hydroxy-2-[n-(2-hydroxyethyl)biphenyl-4-sulfonamide] hydroxamic acid (mlc88) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp3, stmy1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chain: A (161 residues) CATH domain: 3.40.390.10
2jt6		Solution structure of matrix metalloproteinase 3 (mmp-3) in the presence of 3-4'-cyanobyphenyl-4-yloxy)-n-hdydroxypropionamide (mmp-3 inhibitor vii) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp3, stmy1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chain: A (161 residues) CATH domain: 3.40.390.10
2srt		Catalytic domain of human stromelysin-1 at ph 5.5 and 40oc complexed with inhibitor Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Gene: human stromelysin-1. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (173 residues) CATH domain: 3.40.390.10
2usn		Crystal structure of the catalytic domain of human fibroblast stromelysin-1 inhibited with thiadiazole inhibitor pnu-141803 Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: fibroblast. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Chain: A (165 residues) CATH domain: 3.40.390.10
3ohl		Catalytic domain of stromelysin-1 in complex with n-hydroxy-2-(4- methoxy-n-(pyridine-3-ylmethyl)phenylsulfonamido)acetamide Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp3, stmy1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Chain: A (159 residues) CATH domain: 3.40.390.10
3oho		Catalytic domain of stromelysin-1 in complex with n-hydroxy-2-(4- methylphenylsulfonamido)acetamide Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp3, stmy1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Chain: A (159 residues) CATH domain: 3.40.390.10
3usn		Structure of the catalytic domain of human fibroblast stromelysin-1 inhibited with the thiadiazole inhibitor ipnu-107859, nmr, 1 structure Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Cell: fibroblast. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (168 residues) CATH domain: 3.40.390.10
4dpe		Structure of mmp3 complexed with a platinum-based inhibitor. Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp3, stmy1. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B (168 residues) CATH domain: 3.40.390.10
4g9l		Structure of mmp3 complexed with nngh inhibitor. Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp3, stmy1. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B (168 residues) CATH domain: 3.40.390.10
4ja1		Structure of mmp3 complexed with a platinum-based inhibitor Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp3, stmy1. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B (168 residues) CATH domain: 3.40.390.10
6mav		Complex of tissue inhibitor of metalloproteinase-1 (timp-1) mutant l34g with matrix metalloproteinase-3 catalytic domain (mmp-3cd) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp3, stmy1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: timp1, clgi, timp. Expression_system_taxid: 9606 Chain: A (161 residues)
6n9d		Complex of tissue inhibitor of metalloproteinases-1 (timp-1) mutant (l34g/l133p/l151c/g154a) with matrix metalloproteinase-3 catalytic domain (mmp-3cd) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp3, stmy1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: timp1, clgi, timp. Expression_system_taxid: 9606 Chain: A (161 residues)
7s7l		Complex of tissue inhibitor of metalloproteinases-1 (timp-1) mutant (l34g/m66s/e67y/l133n/s155l) with matrix metalloproteinase-3 catalytic domain (mmp-3cd) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp3, stmy1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek-293 freestyle. Gene: timp1, clgi, timp. Expression_system_cell_line: hek-293 freestyle Chain: A (165 residues)
7s7m		Complex of tissue inhibitor of metalloproteinases-1 (timp-1) mutant (l34g/m66d/t98g/p131s/q153n) with matrix metalloproteinase-3 catalytic domain (mmp-3cd) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mmp3, stmy1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek-293 freestyle. Gene: timp1, clgi, timp. Expression_system_cell_line: hek-293 freestyle Chain: A (160 residues)