_EC 3.4.22.15 cathepsin L.

69 PDB entries

EC 3.-.-.- Hydrolases. [51,972 PDB entries] EC 3.4.-.- Acting on peptide bonds (peptidases). [15,920 PDB entries] EC 3.4.22.- Cysteine endopeptidases. [2,934 PDB entries] EC 3.4.22.15 cathepsin L. [69 PDB entries]

1cjl

Reaction:		Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
Comments:		A lysosomal enzyme that is readily inhibited by the diazomethane inhibitor Z-Phe-Phe-CHN2 or the epoxide inhibitor E-64. Belongs to peptidase family C1.
Links:		[IntEnz]   [ExPASy]   [KEGG]

There are 69 PDB entries in enzyme class E.C.3.4.22.15

PDB code		Protein
1cjl		Crystal structure of a cysteine protease proform Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: human cdna. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Other_details: first residue (thr) changed to ser Chain: A (307 residues) CATH domain: 3.90.70.10
1cs8		Crystal structure of procathepsin l Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: A (316 residues) CATH domain: 3.90.70.10
1icf		Crystal structure of mhc class ii associated p41 ii fragment in complex with cathepsin l Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: kidney. Organ: kidney Chains: A, B, C, D (175 residues) CATH domain: 3.90.70.10
1mhw		Design of non-covalent inhibitors of human cathepsin l. From the 96- residue proregion to optimized tripeptides Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Synthetic: yes Chains: A, C, B, D (174 residues) CATH domain: 3.90.70.10
2nqd		Crystal structure of cysteine protease inhibitor, chagasin, in complex with human cathepsin l Source: Trypanosoma cruzi. Organism_taxid: 5693. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: B (221 residues) CATH domain: 3.90.70.10
2p86		The high resolution crystal structure of rhodesain, the major cathepsin l protease from t. Brucei rhodesiense, bound to inhibitor k11002 Source: Trypanosoma brucei rhodesiense. Organism_taxid: 31286. Strain: rhodesiense. Gene: rhodesain. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: A (215 residues) CATH domain: 3.90.70.10
2vhs		Cathsilicatein, a chimera Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Other_details: this is chimera, engineered Chains: A, B, C, D (215 residues) CATH domain: 3.90.70.10
2xu1		Cathepsin l with a nitrile inhibitor Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Chains: A, B, C, D (215 residues) CATH domain: 3.90.70.10
2xu3		Cathepsin l with a nitrile inhibitor Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (220 residues) CATH domain: 3.90.70.10
2xu4		Cathepsin l with a nitrile inhibitor Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (217 residues) CATH domain: 3.90.70.10
2xu5		Cathepsin l with a nitrile inhibitor Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (216 residues) CATH domain: 3.90.70.10
2yj2		Cathepsin l with a nitrile inhibitor Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (219 residues) CATH domain: 3.90.70.10
2yj8		Cathepsin l with a nitrile inhibitor Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (219 residues) CATH domain: 3.90.70.10
2yj9		Cathepsin l with a nitrile inhibitor Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (216 residues) CATH domain: 3.90.70.10
2yjb		Cathepsin l with a nitrile inhibitor Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (220 residues) CATH domain: 3.90.70.10
2yjc		Cathepsin l with a nitrile inhibitor Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (219 residues) CATH domain: 3.90.70.10
3bc3		Exploring inhibitor binding at the s subsites of cathepsin l Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl. Expressed in: pichia pastoris. Expression_system_taxid: 4922 Chains: A, B (215 residues) CATH domain: 3.90.70.10
3f75		Activated toxoplasma gondii cathepsin l (tgcpl) in complex with its propeptide Source: Toxoplasma gondii. Organism_taxid: 383379. Strain: rh. Gene: cpl. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, P (223 residues) CATH domain: 3.90.70.10
3h89		A combined crystallographic and molecular dynamics study of cathepsin- l retro-binding inhibitors(compound 4) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: catehpsin l. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932 Chains: A, B, C, D, E, F (215 residues) CATH domain: 3.90.70.10
3h8b		A combined crystallographic and molecular dynamics study of cathepsin- l retro-binding inhibitors(compound 9) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cathepsin l. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932 Chains: A, B, C, D, E, F (215 residues) CATH domain: 3.90.70.10
3h8c		A combined crystallographic and molecular dynamics study of cathepsin- l retro-binding inhibitors (compound 14) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cathepsin l. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932 Chains: A, B (215 residues) CATH domain: 3.90.70.10
3hha		Crystal structure of cathepsin l in complex with az12878478 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl1, ctsl. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C, D (220 residues) CATH domain: 3.90.70.10
3hwn		Cathepsin l with az13010160 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl1, ctsl. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B, C, D (213 residues) CATH domain: 3.90.70.10
3iv2		Crystal structure of mature apo-cathepsin l c25a mutant Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl1, ctsl. Expressed in: pichia pastoris. Expression_system_taxid: 4922 Chains: A, B (219 residues) CATH domain: 3.90.70.10
3k24		Crystal structure of mature apo-cathepsin l c25a mutant in complex with gln-leu-ala peptide Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl1, ctsl. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Synthetic: yes. Other_details: synthetic peptide Chains: A, B (220 residues) CATH domain: 3.90.70.10
3kse		Unreduced cathepsin l in complex with stefin a Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B, C (220 residues) CATH domain: 3.90.70.10
3of8		Structural basis for reversible and irreversible inhibition of human cathepsin l by their respective dipeptidyl glyoxal and diazomethylketone inhibitors Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl1, ctsl. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: A (221 residues) CATH domain: 3.90.70.10
3of9		Structural basis for irreversible inhibition of human cathepsin l by a diazomethylketone inhibitor Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl1, ctsl. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: A (221 residues) CATH domain: 3.90.70.10
3qj3		Structure of digestive procathepsin l2 proteinase from tenebrio molitor larval midgut Source: Tenebrio molitor. Yellow mealworm beetle. Organism_taxid: 7067. Gene: pcal2. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B (319 residues) CATH domain: 3.90.70.10
3qt4		Structure of digestive procathepsin l 3 of tenebrio molitor larval midgut Source: Tenebrio molitor. Yellow mealworm beetle. Organism_taxid: 7067. Gene: pcal3. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (304 residues) CATH domain: 3.90.70.10
4axl		Human cathepsin l apo form with zn Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (220 residues) CATH domain: 3.90.70.10
4axm		Triazine cathepsin inhibitor complex Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B, F, I, L, O (218 residues) CATH domain: 3.90.70.10
5f02		Cathepsin l in complex with (2s,4r)-4-(2-chloro-4-methoxy- benzenesulfonyl)-1-[3-(5-chloro-pyridin-2-yl)-azetidine-3-carbonyl]- pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (219 residues) CATH domain: 3.90.70.10
5i4h		Caught in the act: the crystal structure of cleaved cathepsin l bound to the active site of cathepsin l Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: komagataella pastoris gs115. Expression_system_taxid: 644223. Expression_system_taxid: 644223 Chains: A, B (106 residues)
5mae		Cathepsin l in complex with (2s,4r)-4-(2-chloro-4-methoxy- benzenesulfonyl)-1-[3-(5-chloro-pyridin-2-yl)-azetidine-3-carbonyl]- pyrrolidine-2-car boxylic acid (1-cyano-cyclopropyl)-amide Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (217 residues)
5maj		Cathepsin l in complex with 4-[cyclopentyl(imidazo[1,2-a]pyridin-2- ylmethyl)amino]-6-morpholino-1,3,5-triazine-2-carbonitrile Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (219 residues)
5mqy		Cathepsin l in complex with 4-[1,3-benzodioxol-5-ylmethyl(2- phenoxyethyl)amino]-5-fluoropyrimidine-2-carbonitrile Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (216 residues)
6ezp		Cathepsin l in complex with (3s,14e)-19-chloro-n-(1-cyanocyclopropyl)- 5-oxo-12,17-dioxa-4-azatricyclo[16.2.2.06,11]docosa-1(21),6(11),7,9, 14,18(22),19-heptaene-3-carboxamide Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (217 residues)
6ezx		Cathepsin l in complex with (3s,14e)-19-chloro-n-(1-cyanocyclopropyl)- 5-oxo-17-oxa-4-azatricyclo[16.2.2.06,11]docosa-1(21),6,8,10,14, 18(22),19-heptaene-3-carboxamide Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B (217 residues)
6f06		Cathepsin l in complex with (3s,14e)-8-(azetidin-3-yl)-19-chloro-n-(1- cyanocyclopropyl)-5-oxo-12,17-dioxa-4-azatricyclo[16.2.2.06, 11]docosa-1(21),6,8,10,14,18(22),19-heptaene-3-carboxamide Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B (220 residues)
6jd0		Structure of mutant human cathepsin l, engineered for gag binding Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (314 residues)
6jd8		Structure of a proline specific mutant of human cathepsin l Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (314 residues)
7avm		Crystal structure of pro-rhodesain c150a Source: Trypanosoma brucei rhodesiense. Organism_taxid: 31286. Gene: rhodesain. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008 Chain: A (307 residues)
7qkb		Crystal structure of human cathepsin l in complex with covalently bound gc376 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: komagataella phaffii gs115. Expression_system_taxid: 644223 Chains: A, B, C, D (220 residues)
7qkc		Crystal structure of human cathepsin l after incubation with sulfo- calpeptin Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: komagataella phaffii gs115. Expression_system_taxid: 644223 Chains: A, B, C, D (220 residues)
7qkd		Crystal structure of human cathepsin l in complex with covalently bound mg132 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: komagataella phaffii gs115. Expression_system_taxid: 644223 Chains: A, B, C, D (220 residues)
7w33		The crystal structure of human ctsl in complex with 14a Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008 Chain: A (220 residues)
7w34		The crystal structure of human ctsl in complex with 14b Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008 Chain: A (220 residues)
7z3t		Crystal structure of apo human cathepsin l Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: komagataella phaffii gs115. Expression_system_taxid: 644223 Chains: A, B, C, D (220 residues)
7z58		Crystal structure of human cathepsin l in complex with covalently bound calpeptin Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: komagataella phaffii gs115. Expression_system_taxid: 644223 Chains: A, B, C, D (220 residues)
7zs7		Crystal structure of human cathepsin l with covalently bound calpain inhibitor vi Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: komagataella phaffii gs115. Expression_system_taxid: 644223 Chains: A, B, C, D (220 residues)
7zvf		Crystal structure of human cathepsin l in complex with covalently bound clik148 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: komagataella phaffii gs115. Expression_system_taxid: 644223 Chains: A, B, C, D (220 residues)
7zxa		Crystal structure of human cathepsin l with covalently bound aloxistatin (e-64d) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: komagataella phaffii gs115. Expression_system_taxid: 644223 Chains: A, B, C, D (220 residues)
8a4u		Crystal structure of human cathepsin l with caa0225 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: komagataella phaffii gs115. Expression_system_taxid: 644223 Chains: A, B, C, D (220 residues)
8a4v		Crystal structure of human cathepsin l with covalently bound e-64 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: komagataella phaffii gs115. Expression_system_taxid: 644223 Chains: A, B, C, D (220 residues)
8a4w		Crystal structure of human cathepsin l with covalently bound cathepsin l inhibitor iv Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: komagataella phaffii gs115. Expression_system_taxid: 644223 Chains: A, B, C, D (220 residues)
8a4x		Crystal structure of human cathepsin l with covalently bound calpain inhibitor iii Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: komagataella phaffii gs115. Expression_system_taxid: 644223 Chains: A, B, C, D (220 residues)
8a5b		Crystal structure of human cathepsin l in complex with covalently bound mg-101 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: komagataella phaffii gs115. Expression_system_taxid: 644223. Synthetic: yes. Synthetic construct. Organism_taxid: 32630 Chains: A, B, C, D (220 residues)
8ahv		Crystal structure of human cathepsin l in complex with calpain inhibitor xii Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: komagataella phaffii gs115. Expression_system_taxid: 644223 Chains: A, B, C, D (220 residues)
8b4f		Crystal structure of human cathepsin l forming a thiohemiacetal with n-boc-2-aminoacetaldehyde Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: komagataella phaffii gs115. Expression_system_taxid: 644223 Chains: A, B, C, D (220 residues)
8c77		Human cathepsin l after reaction with the thiocarbazate inhibitor cid 16725315 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: komagataella phaffii gs115. Expression_system_taxid: 644223 Chains: A, B, C, D (220 residues)
8gx2		The crystal structure of human ctsl in complex with 14c Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008 Chains: A, B (220 residues)
8het		Crystal structure of ctsl in complex with e64d Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (219 residues)
8hfv		Crystal structure of ctsl in complex with k777 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B, C, D (220 residues)
8ofa		Crystal structure of human cathepsin l interacting with tosyl phenylalanyl chloromethyl ketone (tpck) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: komagataella phaffii gs115. Expression_system_taxid: 644223 Chains: A, B, C, D (220 residues)
8oza		Human cathepsin l in complex with covalently bound ca-074 methyl ester Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: komagataella phaffii gs115. Expression_system_taxid: 644223 Chains: A, B, C, D (220 residues)
8prx		Crystal structure of human cathepsin l after reaction with the bound ketoamide inhibitor 13b Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: komagataella phaffii gs115. Expression_system_taxid: 644223 Chains: A, B, C, D (220 residues)
8qkb		Crystal structure of human cathepsin l in complex with the vinyl sulfone inhibitor k777 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl, ctsl1. Expressed in: komagataella phaffii gs115. Expression_system_taxid: 644223 Chains: A, B, C, D (220 residues)
8uac		Cathepsin l in complex with ac1115 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctsl. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768 Chains: A, B (215 residues)