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PDB code
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Protein
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Crystal structure of the fxia catalytic domain in complex with ecotinm84r
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Escherichia coli. Organism_taxid: 562. Gene: eco,eti.
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Chains:
A, B
(237 residues)
CATH domains:
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Crystal structure of the fxia catalytic domain in complex with mutated ecotin
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Escherichia coli. Organism_taxid: 562. Gene: eco,eti.
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Chains:
A, B
(238 residues)
CATH domains:
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Crystal structure of the fxia catalytic domain in complex with ecotin mutant (ecotinp)
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Escherichia coli. Organism_taxid: 562. Gene: eco,eti.
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Chains:
A, B
(237 residues)
CATH domains:
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Crystal structure of the catalytic domain of the coagulation factor xia in complex with benzamidine (s434a-t475a-k437 mutant)
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Expression_system_cell_line: x-33
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Chain:
A
(237 residues)
CATH domains:
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Crystal structure of the catalytic domain of coagulation factor xi in complex with benzamidine (s434a-t475a-k505 mutant)
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Expression_system_cell_line: x-33
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Chain:
A
(237 residues)
CATH domains:
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Crystal structure of the catalytic domain of coagulation factor xi in complex with benzamidine (s434a-t475a-c482s-k437a mutant)
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Expression_system_cell_line: x-33
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Chain:
A
(238 residues)
CATH domains:
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Crystal structure of the catalytic domain of coagulation factor xi in complex with kunitz protease inhibitor domain of protease nexin ii
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Expression_system_cell_line: x-33. Gene: app, a4, ad1f11. Expression_system_cell_line: x-33
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Chain:
A
(237 residues)
CATH domains:
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Factor xi catalytic domain complexed with 2-guanidino-1-(4-(4,4,5,5- tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl nicotinate
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
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Chain:
A
(237 residues)
CATH domains:
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Crystal structure of the catalytic domain of factor xi in complex with 4-(guanidinomethyl)-phenylboronic acid
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
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Chain:
A
(237 residues)
CATH domains:
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Crystal structure of the catalytic domain of factor xi in complex with (r)-1-(4-(4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl)phenethyl) guanidine
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
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Chain:
A
(237 residues)
CATH domains:
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Crystal structure of the catalytic domain of coagulation factor xi in complex with (r)-1-(4-(4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl) phenyl)guanidine
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
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Chain:
A
(237 residues)
CATH domains:
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Crystal structure of the catalytic domain of coagulation factor xi in complex with a peptidomimetic inhibitor
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
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Chain:
A
(237 residues)
CATH domains:
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Crystal structure of the catalytic domain of coagulation factor xi in complex with 4-methyl-pentanoic acid {1-[4-guanidino-1-(thiazole-2- carbonyl)-butylcarbamoyl]-2-methyl-propyl}-amide
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
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Chain:
A
(237 residues)
CATH domains:
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Crystal structure of the catalytic domain of coagulation factor xi in complex with 2-[2-(3-chloro-phenyl)-2-hydroxy-acetylamino]-n-[4- guanidino-1-(thiazole-2-carbonyl)-butyl]-3-methyl-butyramide
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
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Chain:
A
(237 residues)
CATH domains:
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Factor xi catalytic domain complexed with n-((r)-1-(4-bromophenyl) ethyl)urea-asn-val-arg-alpha-ketothiazole
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
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Chain:
A
(233 residues)
CATH domains:
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Factor xi complexed with 3-hydroxypropyl 3-(7-amidinonaphthalene-1- carboxamido)benzenesulfonate
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
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Chain:
A
(237 residues)
CATH domains:
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Crystal structure of the catalytic domain of coagulation factor xi in complex with n-(7-carbamimidoyl-naphthalen-1-yl)-3-hydroxy-2-methyl- benzamide
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
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Chain:
A
(238 residues)
CATH domains:
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Crystal structure of the catalytic domain of coagulation factor xi in complex with 6-carbamimidoyl-4-(3-hydroxy-2-methyl-benzoylamino)- naphthalene-2-carboxylic acid methyl ester
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
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Chain:
A
(238 residues)
CATH domains:
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Factor xi complexed with a pyrimidinone inhibitor
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
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Chain:
A
(237 residues)
CATH domains:
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Crystal structure of the catalytic domain of coagulation factor xi in complex with 2-(5-benzylamino-2-methylsulfanyl-6-oxo-6h-pyrimidin-1- yl)-n-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-acetamide
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
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Chain:
A
(237 residues)
CATH domains:
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Crystal structure of the catalytic domain of coagulation factor xi in complex with 2-(5-amino-6-oxo-2-m-tolyl-6h-pyrimidin-1-yl)-n-[4- guanidino-1-(thiazole-2-carbonyl)-butyl]-acetamide
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
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Chain:
A
(237 residues)
CATH domains:
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Crystal structure of the catalytic domain of coagulation factor xi in complex with n-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-2-{6-oxo- 5-[(quinolin-8-ylmethyl)-amino]-2-m-tolyl-6h-pyrimidin-1-yl}- acetamide
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
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Chain:
A
(237 residues)
CATH domains:
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Crystal structure of the catalytic domain of human coagulation factor xia in complex with alpha-ketothiazole arginine derived ligand
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
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Chain:
A
(237 residues)
CATH domains:
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Solution structure of the a4 domain of blood coagulation factor xi
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Source: Homo sapiens. Human. Organism_taxid: 9606
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Chains:
A, B
(90 residues)
CATH domain:
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Fxi apple 4 domain loop-out conformation
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Source: Homo sapiens. Human. Organism_taxid: 9606
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Chains:
A, B
(90 residues)
CATH domain:
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Crystal structure of factor xia in complex with clavatadine a
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
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Chain:
A
(238 residues)
CATH domains:
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Factor xia in complex with a clorophenyl-tetrazole inhibitor
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: komagataella pastoris. Expression_system_taxid: 4922
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Chain:
A
(236 residues)
CATH domains:
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Benzothiazinone inhibitor in complex with fxia
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: komagataella pastoris. Expression_system_taxid: 4922
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Chain:
A
(236 residues)
CATH domains:
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Creating novel f1 inhibitors through fragment based lead generation and structure aided drug design
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922
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Chain:
A
(238 residues)
CATH domains:
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Creating novel f1 inhibitors through fragment based lead generation and structure aided drug design
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922
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Chain:
A
(238 residues)
CATH domains:
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Creating novel f1 inhibitors through fragment based lead generation and structure aided drug design
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: komagataella pastoris. Expression_system_taxid: 4922
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Chain:
A
(238 residues)
CATH domains:
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Creating novel f1 inhibitors through fragment based lead generation and structure aided drug design
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922
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Chain:
A
(238 residues)
CATH domains:
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Creating novel f1 inhibitors through fragment based lead generation and structure aided drug design
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922
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Chain:
A
(237 residues)
CATH domains:
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Creating novel f1 inhibitors through fragment based lead generation and structure aided drug design
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922
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Chain:
A
(236 residues)
CATH domains:
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Creating novel f1 inhibitors through fragment based lead generation and structure aided drug design
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922
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Chain:
A
(238 residues)
CATH domains:
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Creating novel f1 inhibitors through fragment based lead generation and structure aided drug design
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: pichia pastoris. Expression_system_taxid: 4922
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Chain:
A
(238 residues)
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Creating novel f1 inhibitors through fragment based lead generation and structure aided drug design
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922
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Chain:
A
(234 residues)
CATH domains:
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Human fxia in complex with small molecule inhibitors.
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: komagataella pastoris. Expression_system_taxid: 4922
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Chain:
A
(236 residues)
CATH domains:
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Human fxia in complex with small molecule inhibitors.
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: komagataella pastoris. Expression_system_taxid: 4922
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Chain:
A
(236 residues)
CATH domains:
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Human fxia in complex with small molecule inhibitors.
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: komagataella pastoris. Expression_system_taxid: 4922
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Chain:
A
(236 residues)
CATH domains:
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Factor xia in complex with the inhibitor 3'-[(2s,4r)-6-carbamimidoyl- 4-methyl-4-phenyl-1,2,3,4-tetrahydroquinolin-2-yl]-4-carbamoyl-5'- [(3-methylbutanoyl)amino]biphenyl-2-carboxylic acid
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Chain:
A
(238 residues)
CATH domains:
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Factor xia in complex with the inhibitor 5-aminocarbonyl-2-[3-[(2s, 4r)-6-carbamimidoyl-4-methyl-4-phenyl-2,3-dihydro-1h-quinolin-2- yl]phenyl]benzoic acid
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chain:
A
(238 residues)
CATH domains:
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Factor xia in complex with the inhibitor 4-{2-[(1s)-1-({[trans-4- (aminomethyl)cyclohexyl]carbonyl}amino)-2-phenylethyl]-1h-imidazol-4- yl}benzamide
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Chain:
A
(238 residues)
CATH domains:
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Factor xia in complex with the inhibitor (2s)-6-amino-n-{(1s)-1-[4-(3- amino-2h-indazol-6-yl)-5-chloro-1h-imidazol-2-yl]-2-phenylethyl}-2- ethylhexanamide
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Chain:
A
(238 residues)
CATH domains:
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Factor xia in complex with the inhibitor trans-n-{(1s)-1-[4-(3-amino- 2h-indazol-6-yl)pyridin-2-yl]-2-phenylethyl}-4-(aminomethyl) cyclohexanecarboxamide
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
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Chain:
A
(238 residues)
CATH domains:
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Factor xia in complex with the inhibitor 1-{(1s)-1-[4-(3-amino-1h- indazol-6-yl)-5-chloro-1h-imidazol-2-yl]-2-phenylethyl}-3-[2- (aminomethyl)-5-chlorobenzyl]urea
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chain:
A
(238 residues)
CATH domains:
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Factor xia in complex with the inhibitor 1-{(1s)-1-[4-(3-amino-1h- indazol-6-yl)-5-chloro-1h-imidazol-2-yl]-2-phenylethyl}-3-[5-chloro- 2-(1h-tetrazol-1-yl)benzyl]urea
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chain:
A
(238 residues)
CATH domains:
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Factor xia in complex with the inhibitor methyl (4-{4-chloro-2-[(1s)- 1-({3-[5-chloro-2-(1h-tetrazol-1-yl)phenyl]propanoyl}amino)-2- phenylethyl]-1h-imidazol-5-yl}phenyl)carbamate
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chain:
A
(238 residues)
CATH domains:
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Factor xia (pichia pastoris; c500s [c122s]) in complex with the inhibitor (2e)-n-{(1s)-1-[4-(3-amino-1h-indazol-6-yl)-1h-imidazol-2- yl]-2-phenylethyl}-3-[5-chloro-2-(1h-tetrazol-1-yl)phenyl]prop-2- enamide
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: komagataella pastoris. Expression_system_taxid: 4922.
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Chains:
A, B
(236 residues)
CATH domains:
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Factor xia in complex with the inhibitor methyl (4-{4-chloro-2-[(1s)- 1-({(2e)-3-[5-chloro-2-(1h-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)- 2-phenylethyl]-1h-imidazol-5-yl}phenyl)carbamate
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
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Chain:
A
(238 residues)
CATH domains:
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Factor xia in complex with the inhibitor methyl (4-{4-chloro-2-[(1s)- 1-({(2e)-3-[5-chloro-2-(1h-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)- 3-(morpholin-4-yl)-3-oxopropyl]-1h-imidazol-5-yl}phenyl)carbamate
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
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Chain:
A
(238 residues)
CATH domains:
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Factor xia in complex with the inhibitor (2e)-n-[(1s)-1-[5-chloro-4- (4-hydroxy-2-oxo-1,2-dihydroquinolin-6-yl)-1h-imidazol-2-yl]-3-(4- methylpiperazin-1-yl)-3-oxopropyl]-3-[5-chloro-2-(1h-tetrazol-1-yl) phenyl]prop-2-enamide
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
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Chain:
A
(238 residues)
CATH domains:
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Factor xia in complex with the inhibitor 4-[(n-{(2e)-3-[5-chloro-2- (1h-tetrazol-1-yl)phenyl]prop-2-enoyl}-l-phenylalanyl)amino]benzoic acid
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chain:
A
(238 residues)
CATH domains:
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Factor xia in complex with the inhibitor n-[(1s)-1-benzyl-2-[2-[5- chloro-2-(tetrazol-1-yl)phenyl]ethylamino]-2-oxo-ethyl]-4-hydroxy-2- oxo-1h-quinoline-6-carboxamide
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chain:
A
(238 residues)
CATH domains:
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Human plasma coagulation fxi with peptide lp2
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expressed in: synthetic construct. Expression_system_taxid: 32630
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Chain:
A
(586 residues)
CATH domains:
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Human plasma coagulation factor xi in complex with peptide p39
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
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Chain:
A
(589 residues)
CATH domains:
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Factor xia in complex with the inhibitor 4-(aminomethyl)-~{n}- [(1~{s})-1-[4-(3-oxidanyl-1~{h}-indazol-5-yl)pyridin-2-yl]-2-phenyl- ethyl]cyclohexane-1-carboxamide
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chain:
A
(238 residues)
CATH domains:
|
|
|
|
|
|
Factor xia in complex with the inhibitor methyl ~{n}-[4-[2-[(1~{s})-1- [[4-(aminomethyl)cyclohexyl]carbonylamino]-2-phenyl-ethyl]pyridin-4- yl]phenyl]carbamate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(238 residues)
CATH domains:
|
|
|
|
|
|
Factor xia (c500s [c122s]) in complex with the inhibitor methyl ~{n}- [4-[2-[(1~{s})-1-[[(~{e})-3-[5-chloranyl-2-(1,2,3,4-tetrazol-1-yl) phenyl]prop-2-enoyl]amino]-2-phenyl-ethyl]pyridin-4- yl]phenyl]carbamate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: komagataella pastoris. Expression_system_taxid: 4922.
|
|
|
Chain:
A
(237 residues)
CATH domains:
|
|
|
|
|
|
Human recombinant coagulation fxi in complex with a peptide derived from human high molecular weight kininogen (hkp)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expressed in: synthetic construct. Expression_system_taxid: 32630
|
|
|
Chain:
A
(596 residues)
CATH domains:
|
|
|
|
|
|
Factor xia in complex with the inhibitor methyl [(7s)-7-({(2e)-3-[5- chloro-2-(1h-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)-2-oxo-1,2,3,4, 5,6,7,9-octahydro-11,8-(azeno)-1,9-benzodiazacyclotridecin-14- yl]carbamate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(238 residues)
|
|
|
|
|
|
Factor xia in complex with the inhibitor methyl [(4s,8s)-8-({(2e)-3- [5-chloro-2-(1h-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)-4-methyl-2- oxo-1,3,4,5,6,7,8,10-octahydro-2h-12,9-(azeno)-1,10- benzodiazacyclotetradecin-15-yl]carbamate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(238 residues)
|
|
|
|
|
|
Factor xia in complex with the inhibitor methyl [(4r,5e,8s)-8-({(2e)- 3-[5-chloro-2-(1h-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)-4-methyl- 2-oxo-1,3,4,7,8,10-hexahydro-2h-12,9-(azeno)-1,10- benzodiazacyclotetradecin-15-yl]carbamate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 469008. Organism_taxid: 9606
|
|
|
Chain:
A
(238 residues)
|
|
|
|
|
|
Factor xia in complex with the inhibitor methyl [(3r,7s)-7-({(2e)-3- [5-chloro-2-(1h-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)-3-ethyl-2- oxo-1,2,3,4,5,6,7,9-octahydro-11,8-(azeno)-1,9- benzodiazacyclotridecin-14-yl]carbamate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(238 residues)
|
|
|
|
|
|
Factor xia in complex with the inhibitor methyl [(4r,5e,8s)-11-chloro- 8-[(2,6-difluoro-4-methylbenzene-1-carbonyl)amino]-4-methyl-2-oxo-1, 3,4,7,8,10-hexahydro-2h-12,9-(azeno)-1,10-benzodiazacyclotetradecin- 15-yl]carbamate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(238 residues)
|
|
|
|
|
|
Factor xia in complex with the inhibitor 4-[[(2~{s},3~{r})-1-[(~{e})- 3-[5-chloranyl-2-(1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoyl]-3- phenyl-pyrrolidin-2-yl]carbonylamino]benzoic acid
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(238 residues)
|
|
|
|
|
|
Factor xia in complex with the inhibitor 4-[[(1~{s})-2-[(~{e})-3-[5- chloranyl-2-(1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoyl]-3,4-dihydro- 1~{h}-isoquinolin-1-yl]carbonylamino]benzoic acid
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(238 residues)
|
|
|
|
|
|
Factor xia in complex with the inhibitor methyl ~{n}-[4-[[(1~{s})-2- [(~{e})-3-[3-chloranyl-2-fluoranyl-6-(1,2,3,4-tetrazol-1-yl) phenyl]prop-2-enoyl]-3,4-dihydro-1~{h}-isoquinolin-1- yl]carbonylamino]phenyl]carbamate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(238 residues)
|
|
|
|
|
|
Factor xia in complex with the inhibitor 4-[[(1~{s})-2-[(~{e})-3-[5- chloranyl-2-(1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoyl]-5-[(3~{s})-3- ethoxycarbonylpiperidin-1-yl]carbonyl-3,4-dihydro-1~{h}-isoquinolin- 1-yl]carbonylamino]benzoic acid
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(238 residues)
|
|
|
|
|
|
Factor xia in complex with the inhibitor methyl [(5e,8s)-8-[(6r)-6-(3- chlorophenyl)-2-oxo-1,3-oxazinan-3-yl]-2-oxo-1,3,4,7,8,10-hexahydro- 2h-12,9-(azeno)-1,10-benzodiazacyclotetradecin-15-yl]carbamate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
|
|
|
Chain:
A
(238 residues)
|
|
|
|
|
|
Factor xia in complex with the inhibitor methyl [(5e,8s)-8-[(4s)-4-(3- chlorophenyl)-2-oxopiperidin-1-yl]-2-oxo-1,3,4,7,8,10-hexahydro-2h- 12,9-(azeno)-1,10-benzodiazacyclotetradecin-15-yl]carbamate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(238 residues)
|
|
|
|
|
|
Factor xia in complex with the inhibitor methyl [(3r,7s)-7-{[5-amino- 1-(3-chloro-2-fluorophenyl)-1h-pyrazole-4-carbonyl]amino}-3-methyl-2- oxo-2,3,4,5,6,7-hexahydro-1h-12,8-(metheno)-1,9- benzodiazacyclotetradecin-15-yl]carbamate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(238 residues)
|
|
|
|
|
|
Factor xia in complex with the inhibitor methyl [(3r,7s)-7-{[1-(3- chloro-2-fluorophenyl)-5-methyl-1h-imidazole-4-carbonyl]amino}-3- methyl-2-oxo-2,3,4,5,6,7-hexahydro-1h-12,8-(metheno)-1,9- benzodiazacyclotetradecin-15-yl]carbamate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(238 residues)
|
|
|
|
|
|
Factor xia in complex with the inhibitor methyl [(2r,7s)-7-({(2e)-3- [5-chloro-2-(1h-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)-2- (trifluoromethyl)-2,3,4,5,6,7-hexahydro-1h-8,11-epimino-1,9- benzodiazacyclotridecin-14-yl]carbamate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469908.
|
|
|
Chain:
A
(238 residues)
|
|
|
|
|
|
Factor xia in complex with the inhibitor methyl (2r,7s)-7-({(2e)-3-[5- chloro-2-(1h-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)-14- [(methoxycarbonyl)amino]-2,3,4,5,6,7-hexahydro-1h-8,11-epimino-1,9- benzodiazacyclotridecine-2-carboxylate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(238 residues)
|
|
|
|
|
|
Factor xia in complex with the inhibitor ethyl (2r,7s)-7-({(2e)-3-[5- chloro-2-(1h-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)-14- [(methoxycarbonyl)amino]-1,2,3,4,5,6,7,9-octahydro-11,8-(azeno)-1,9- benzodiazacyclotridecine-2-carboxylate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(238 residues)
|
|
|
|
|
|
Factor xia in complex with the inhibitor ethyl (2r,7s)-7-({(2e)-3-[5- chloro-2-(1h-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)-15- [(methoxycarbonyl)amino]-2,3,4,5,6,7-hexahydro-1h-12,8-(metheno)-1,9- benzodiazacyclotetradecine-2-carboxylate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(238 residues)
|
|
|
|
|
|
Factor xia in complex with the inhibitor ((15s)-18-chloro- 15-(((2e)- 3-(5-chloro-2-(1h-tetrazol-1-yl)phenyl)-2- propenoyl)amino)-17,19- diazatricyclo[14.2.1.0~2,7~]nonadeca-1(18),2,4,6,16(19)-pentaen-5- yl)carbamate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(238 residues)
|
|
|
|
|
|
Factor xia in complex with the inhibitor methyl ((12e,15s)-15-(((2e)- 3-(5-chloro-2-(1h-tetrazol-1-yl)phenyl)-2-propenoyl)amino)-9-oxo-8, 17,19-triazatricyclo[14.2.1.0~2,7~]nonadeca-1(18),2,4,6,12,16(19)- hexaen-5-yl)carbamate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(238 residues)
|
|
|
|
|
|
Factor xia in complex with the inhibitor methyl ((15s)-15-(((2e)-3-(5- chloro-2-(1h-tetrazol-1-yl)phenyl)-2-propenoyl)amino)-9-oxo-8,17,19- triazatricyclo[14.2.1.0~2,7~]nonadeca-1(18),2,4,6,16(19)-pentaen-5- yl)carbamate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(238 residues)
|
|
|
|
|
|
Factor xia in complex with the inhibitor methyl [(11s)-11-({(2e)-3-[5- chloro-2-(1h-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)-6-fluoro-2-oxo- 1,3,4,10,11,13-hexahydro-2h-5,9:15,12-di(azeno)-1,13- benzodiazacycloheptadecin-18-yl]carbamate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(238 residues)
|
|
|
|
|
|
Fxia antibody complex
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Human. Gene: f11. Expression_system_taxid: 9606
|
|
|
Chain:
C
(236 residues)
|
|
|
|
|
|
Factor xia in complex with the inhibitor methyl (4-{6-[(1s)-2-[(3r)-1- acetylpiperidin-3-yl]-1-({(2e)-3-[5-chloro-2- (1h-tetrazol-1-yl) phenyl]prop-2-enoyl}amino)ethyl]-3-chloropyridazin-4-yl}phenyl) carbamate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(238 residues)
|
|
|
|
|
|
Allosteric inhibition as a new mode of action for bay 1213790, a neutralizing antibody targeting the activated form of coagulation factor xi
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: f11. Expression_system_taxid: 9606
|
|
|
Chain:
A
(229 residues)
|
|
|
|
|
|
Allosteric activation of human prekallikrein by apple domain disc rotation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chain:
A
(585 residues)
|
|
|
|
|
|
Coagulation factor xi catalytic domain in complex with fab-portion of maa868
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Unidentified. Organism_taxid: 32644.
|
|
|
Chain:
A
(228 residues)
|
|
|
|
|
|
Coagulation factor xi protease domain in complex with active site inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333
|
|
|
Chain:
A
(236 residues)
|
|
|
|
|
|
Coagulation factor xi protease domain in complex with active site inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(236 residues)
|
|
|
|
|
|
Coagulation factor xi protease domain in complex with active site inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(236 residues)
|
|
|
|
|
|
Coagulation factor xi protease domain in complex with active site inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(236 residues)
|
|
|
|
|
|
Crystal structure of the catalytic domain of coagulation factor xia in complex with double bridged peptide f19
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chain:
A
(238 residues)
|
|
|
|
|
|
Crystal structure of the catalytic domain of the coagulation factor xia in complex with double bridged peptide f21
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chain:
A
(238 residues)
|
|
|
|
|
|
Coagulation factor xi catalytic domain (c123s) in complex with nvp- xiv936
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(236 residues)
|
|
|
|
|
|
Factor xia in complex with compound 7
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: komagataella pastoris. Expression_system_taxid: 4922
|
|
|
Chain:
A
(236 residues)
|
|
|
|
|
|
Factor xia in complex with compound 11
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: komagataella pastoris. Expression_system_taxid: 4922
|
|
|
Chain:
A
(236 residues)
|
|
|
|
|
|
Factor xia in complex with the inhibitor methyl ((10r,14s)- 14-(4-(3- chloro-2,6-difluorophenyl)-6-oxo-3,6-dihydro- 1(2h)-pyridinyl)-10- methyl-9-oxo-8,16- diazatricyclo[13.3.1.0~2,7~]nonadeca-1(19),2,4,6, 15,17- hexaen-5-yl)carbamate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(238 residues)
|
|
|
|
|
|
The crystal structure of fxia serine protease domain in complex with benzamidine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: komagataella pastoris. Expression_system_taxid: 4922
|
|
|
Chains:
A, B, C, D
(236 residues)
|
|
|
|
|
|
Factor xia (pichia pastoris; c500s [c122s]) in complex with the inhibitor milvexian (bms-986177), iupac name:(6r,10s)-10-{4-[5- chloro-2-(4-chloro-1h-1,2,3-triazol-1-yl)phenyl]-6- oxopyrimidin- 1(6h)-yl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-15,11- (metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6h)-one
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: komagataella pastoris. Expression_system_taxid: 4922
|
|
|
Chain:
A
(237 residues)
|
|
|
|
|
|
Factor xi and plasma kallikrein apple domain structures reveals different kininogen bound complexes
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227. Gene: kng1, bdk, kng. Expression_system_taxid: 7227
|
|
|
Chains:
A, B
(355 residues)
|
|
|
|
|
|
Factor xia in complex with compound 2a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: komagataella pastoris. Expression_system_taxid: 4922
|
|
|
Chain:
A
(237 residues)
|
|
|
|
|
|
Factor xia in complex with compound 2d
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: komagataella pastoris. Expression_system_taxid: 4922
|
|
|
Chain:
A
(236 residues)
|
|
|
|
|
|
Factor xia in complex with compound 2e
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: komagataella pastoris. Expression_system_taxid: 4922
|
|
|
Chain:
A
(236 residues)
|
|
|
|
|
|
Factor xia in complex with compound 2f
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: komagataella pastoris. Expression_system_taxid: 4922
|
|
|
Chain:
A
(236 residues)
|
|
|
|
|
|
Factor xia in complex with compound 2g
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: komagataella pastoris. Expression_system_taxid: 4922
|
|
|
Chain:
A
(236 residues)
|
|
|
|
|
|
Factor xia in complex with compound 2h
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: komagataella pastoris. Expression_system_taxid: 4922
|
|
|
Chain:
A
(236 residues)
|
|
|
|
|
|
Factor xia in complex with compound 2i
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: komagataella pastoris. Expression_system_taxid: 4922
|
|
|
Chain:
A
(236 residues)
|
|
|
|
|
|
Factor xia in complex with compound 2j
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: komagataella pastoris. Expression_system_taxid: 4922
|
|
|
Chain:
A
(236 residues)
|
|
|
|
|
|
Factor xia in complex with compound 2k
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: komagataella pastoris. Expression_system_taxid: 4922
|
|
|
Chain:
A
(236 residues)
|
|
|
|
|
|
Factor xia in complex with compound 3f
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f11. Expressed in: komagataella pastoris. Expression_system_taxid: 4922
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Chain:
A
(236 residues)
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[IntEnz]
[ExPASy]
[KEGG]
