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PDB code
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Protein
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N-terminal egf-like domain from human factor vii, nmr, 23 structures
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Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood
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Chain:
A
(41 residues)
CATH domain:
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Crystal structure of active site-inhibited human coagulation factor viia (des-gla)
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_organ: ovary. Expression_system_organ: ovary
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Chains:
L, H
(55 residues)
CATH domain:
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Complex of active site inhibited human blood coagulation factor viia with human recombinant soluble tissue factor
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Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: baby hamster kidney cells. Organ: blood. Expressed in: mesocricetus auratus. Expression_system_taxid: 10036. Expression_system_cell_line: bhk cells. Expressed in: escherichia coli.
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Chains:
L, H
(142 residues)
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Crystal structure of the complex between the peptide exosite inhibitor e-76 and coagulation factor viia
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Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: liver. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: human kidney cell line 293. Synthetic: yes. Other_details: peptide e-76 was synthesized on a solid support, then
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Chains:
H, L, I, M
(254 residues)
CATH domains:
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The first egf-like domain from human blood coagulation fvii, nmr, 20 structures
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
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Chain:
A
(46 residues)
CATH domain:
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The first egf-like domain from human blood coagulation fvii, nmr, minimized average structure
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
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Chain:
A
(46 residues)
CATH domain:
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Human tissue factor complexed with coagulation factor viia inhibited with a bpti-mutant
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: kidney cells (bhk). Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes.
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Chains:
L, H
(108 residues)
CATH domains:
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The first egf-like domain from human blood coagulation fvii (fucosylated at ser-60), nmr, 20 structures
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
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Chain:
A
(46 residues)
CATH domain:
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The first egf-like domain from human blood coagulation fvii (fucosylated at ser-60), nmr, minimized average structure
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
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Chain:
A
(46 residues)
CATH domain:
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Crystal structure of tissue factor-factor viia complex
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: bhk. Expression_system_cell_line: bhk
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Chains:
L, H
(95 residues)
CATH domains:
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Coagulation factor vii zymogen (egf2/protease) in complex with inhibitory exosite peptide a-183
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Escherichia coli. Organism_taxid: 562. Gene: synthetic construct. Expressed in: escherichia coli.
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Chains:
H, L
(239 residues)
CATH domains:
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Cofactor-and substrate-assisted activation of factor viia
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
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Chains:
L, H
(61 residues)
CATH domain:
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Crystal structure of uninhibited factor viia
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
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Chains:
L, H
(56 residues)
CATH domain:
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Dissecting and designing inhibitor selectivity determinants at the s1 site using an artificial ala190 protease (ala190 upa)
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: 293. Expression_system_organ: embryonic kidney. Gene: f3.
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Chains:
L, H
(96 residues)
CATH domains:
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Structure of human factor viia and its implications for the triggering of blood coagulation
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Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Expressed in: mesocricetus auratus. Expression_system_taxid: 10036. Expression_system_cell_line: bhk570. Expression_system_collection: atcc crl 1632. Expression_system_organelle: nucleus.
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Chains:
L, H
(96 residues)
CATH domains:
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Tf7a_3771 complex
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: baby hamster kidney cells (bhk). Expressed in: escherichia coli. Expression_system_taxid: 562
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Chains:
H, L
(251 residues)
CATH domains:
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Tf7a_4380 complex
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: mesocricetus auratus. Expression_system_taxid: 10036. Expression_system_cell_line: kidney cells (bhk). Expressed in: escherichia coli. Expression_system_taxid: 562
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Chains:
H, L
(251 residues)
CATH domains:
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Factor7 - 413 complex
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
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Chains:
H, L
(250 residues)
CATH domains:
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Factor7 - 413 complex
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
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Chains:
H, L
(247 residues)
CATH domains:
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Human factor viia-tissue factor complexed with propylsulfonamide-d- thr-met-p-aminobenzamidine
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell: cho. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chains:
L, H
(142 residues)
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Human factor viia-tissue factor in complex with peptide-mimetic inhibitor that has two charged groups in p2 and p4
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell: cho. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chains:
L, H
(142 residues)
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Human factor viia-tissue factor complexed with ethylsulfonamide-d- biphenylalanine-gln-p-aminobenzamidine
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell: cho. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chains:
L, H
(142 residues)
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Human factor viia-tissue factor complexed with ethylsulfonamide-d-trp- gln-p-aminobenzamidine
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell: cho. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chains:
L, H
(142 residues)
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Human factor viia-tissue factor complexed with ethylsulfonamide-d-5- propoxy-trp-gln-p-aminobenzamidine
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell: cho. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chains:
L, H
(142 residues)
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Short factor viia with a small molecule inhibitor
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
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Chains:
H, L
(254 residues)
CATH domains:
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Crystal structure of a ternary complex of factor viia/tissue factor/pyrazinone inhibitor
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_organ: kidney. Gene: f3. Expressed in: escherichia coli.
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Chains:
L, H
(142 residues)
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Complex of active-site inhibited human coagulation factor viia with human soluble tissue factor in the presence of ca2+, mg2+, na+, and zn2+
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: mesocricetus auratus. Expression_system_taxid: 10036. Expression_system_cell_line: bhk. Other_details: plasmid. Gene: f3.
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Chains:
L, H
(142 residues)
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Crystal structure of a ternary complex of factor viia/tissue factor and 2-[[6-[3-(aminoiminomethyl)phenoxy]-3,5-difluro-4-[(1-methyl-3- phenylpropyl)amino]-2-pyridinyl]oxy]-benzoic acid
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_organ: kidney. Gene: f3. Expressed in: saccharomyces cerevisiae.
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Chains:
L, H
(142 residues)
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Crystal structure of benzamidine-factor viia/soluble tissue factor complex.
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Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
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Chains:
L, H
(142 residues)
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Factor viia inhibitors: chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in a baboon thrombosis model
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek 293. Expression_system_atcc_number: crl-1573. Gene: f3.
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Chains:
L, H
(94 residues)
CATH domains:
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Crystal structure of glu-gly-arg-chloromethyl ketone-factor viia/soluble tissue factor complex
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Gene: f3
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Chains:
L, H
(142 residues)
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Orally available factor7a inhibitor
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
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Chains:
H, L
(254 residues)
CATH domains:
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Crystal structure of factor vii.Stf complexed with pd0297121
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Source: Synthetic: yes. Homo sapiens. Organism_taxid: 9606. Organism_taxid: 9606
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Chains:
H, L
(254 residues)
CATH domains:
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Crystal structure analysis of human factor viia , souluble tissue factor complexed with bcx-3607
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chains:
L, H
(142 residues)
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Discovery of novel heterocyclic factor viia inhibitors
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: embryonic kidney cell line 293. Gene: f3. Expressed in: escherichia coli.
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Chains:
L, H
(94 residues)
CATH domains:
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Crystal structure of dfpr-viia/stf
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: bhk/vp16. Gene: f3. Expressed in: escherichia coli.
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Chains:
L, H
(142 residues)
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Discovery of a novel hydroxy pyrazole based factor ixa inhibitor
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: f3.
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Chains:
L, H
(96 residues)
CATH domains:
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Novel 5-azaindole factor viia inhibitors
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: f3.
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Chains:
L, H
(96 residues)
CATH domains:
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Crystal structure of active site inhibited coagulation factor viia in complex with soluble tissue factor
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: hampster ovary cells. Gene: ace. Expressed in: escherichia coli.
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Chains:
L, H
(94 residues)
CATH domains:
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Human factor viia-tissue factor complexed with benzylsulfonamide-d- ile-gln-p-aminobenzamidine
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetulus griseus. Expression_system_cell: cho. Gene: f3. Expressed in: escherichia coli.
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Chains:
L, H
(142 residues)
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Human factor viia-tissue factor complexed with highly selective peptide inhibitor
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: cho. Gene: f3. Expressed in: escherichia coli.
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Chains:
L, H
(142 residues)
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Human factor viia-tissue factor complexed with ethylsulfonamide-d-5- (3-carboxybenzyloxy)-trp-gln-p-aminobenzamidine
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: cho. Gene: f3. Expressed in: escherichia coli.
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Chains:
L, H
(142 residues)
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Crystal structure of active site inhibited coagulation factor viia mutant in complex with soluble tissue factor
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: cho-k1. Gene: f3. Expressed in: escherichia coli.
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Chains:
L, H
(95 residues)
CATH domains:
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Mg2+ is required for optimal folding of the gamma-carboxyglutamic acid (gla) domains of vitamin k-dependent clotting factors at physiological ca2+
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Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: blood. Other_details: blood
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Chains:
L, H
(142 residues)
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Mg2+ is required for optimal folding of the gamma-carboxyglutamic acid (gla) domains of vitamin k-dependent clotting factors at physiological ca2+
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Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: blood. Other_details: blood
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Chains:
L, H
(96 residues)
CATH domains:
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Mg2+ is required for optimal folding of the gamma-carboxyglutamic acid (gla) domains of vitamin k-dependent clotting factors at physiological ca2+
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Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: blood. Other_details: blood
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Chains:
L, H
(142 residues)
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Rubidium sites in blood coagulation factor viia
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Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Other_details: this sequence occurs naturally in humans. Other_details: this sequence occurs naturally in humans
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Chains:
L, H
(140 residues)
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Structure of factor viia in complex with the inhibitor bms-593214 also known as 2'-[(6r,6ar,11br)-2-carbamimidoyl-6,6a,7,11b-tetrahydro-5h- indeno[2,1-c]quinolin-6-yl]-5'-hydroxy-4'-methoxybiphenyl-4- carboxylic acid
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_taxid: 10026
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Chains:
H, L
(254 residues)
CATH domains:
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Structure of factor viia in complex with the inhibitor (6s)-n-(4- carbamimidoylbenzyl)-1-chloro-3-(cyclobutylamino)-8,8-diethyl-4-oxo- 4,6,7,8-tetrahydropyrrolo[1,2-a]pyrazine-6-carboxamide
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_taxid: 10026
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Chains:
H, L
(254 residues)
CATH domains:
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Structure of factor viia in complex with the inhibitor (2r)-2-[(1- aminoisoquinolin-6-yl)amino]-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-n- (phenylsulfonyl)ethanamide
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_taxid: 10026
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Chains:
H, L
(254 residues)
CATH domains:
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Structure of factor viia in complex with the inhibitor (2r)-2-[3- ethoxy-4-(propan-2-yloxy)phenyl]-2-(isoquinolin-6-ylamino)-n-[(3- sulfamoylphenyl)sulfonyl]ethanamide
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_taxid: 10026
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Chains:
H, L
(254 residues)
CATH domains:
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Structure of factor viia in complex with the inhibitor 2-{2-[(4- carbamimidoylphenyl)carbamoyl]-6-methoxypyridin-3-yl}-5-{[(2s)-1- hydroxy-3,3-dimethylbutan-2-yl]carbamoyl}benzoic acid
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_taxid: 10026
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Chains:
H, L
(254 residues)
CATH domains:
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Structure of factor viia in complex with the inhibitor 2-{2-[(1- aminoisoquinolin-6-yl)carbamoyl]-6-methoxypyridin-3-yl}-5-{[(2s)-1- hydroxy-3,3-dimethylbutan-2-yl]carbamoyl}benzoic acid
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_taxid: 10026
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Chains:
H, L
(254 residues)
CATH domains:
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Structure of factor viia in complex with the inhibitor 2-{2-[(3- carbamoylphenyl)carbamoyl]-6-methoxypyridin-3-yl}-5-{[(2s)-1-hydroxy- 3,3-dimethylbutan-2-yl]carbamoyl}benzoic acid
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_taxid: 10026
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Chains:
H, L
(254 residues)
CATH domains:
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Factor viia in complex with the inhibitor 3'-amino-5'-[(2s,4r)-6- carbamimidoyl-4-phenyl-1,2,3,4-tetrahydroquinolin-2-yl]biphenyl-2- carboxylic acid
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_taxid: 10026
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Chains:
H, L
(254 residues)
CATH domains:
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Factor viia in complex with the inhibitor (2r)-2-[(1-aminoisoquinolin- 6-yl)amino]-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-n-(3- sulfamoylbenzyl)ethanamide
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Gene: f7. Expression_system_taxid: 10029
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Chains:
H, L
(250 residues)
CATH domains:
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Factor viia in complex with the inhibitor (2r)-2-[(1-aminoisoquinolin- 6-yl)amino]-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-n-[2-(propan-2- ylsulfonyl)benzyl]ethanamide
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_taxid: 10029
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|
Chains:
H, L
(254 residues)
CATH domains:
|
|
|
|
|
|
Factor viia in complex with the inhibitor 4-bromo-2-methoxyphenol
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_taxid: 10026
|
|
|
Chains:
H, L
(249 residues)
CATH domains:
|
|
|
|
|
|
Factor viia in complex with the inhibitor 7-chloro-3,4- dihydroisoquinolin-1(2h)-one
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_taxid: 10026
|
|
|
Chains:
H, L
(250 residues)
CATH domains:
|
|
|
|
|
|
Factor viia in complex with the inhibitor 5-chloro-1h-indole-2- carboxylic acid
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_taxid: 10026
|
|
|
Chains:
H, L
(251 residues)
CATH domains:
|
|
|
|
|
|
Factor viia in complex with the inhibitor (methyl {3-[(2r)-1-{(2r)-2- (3,4-dimethoxyphenyl)-2-[(1-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl) amino]acetyl}pyrrolidin-2-yl]-4-(propan-2-ylsulfonyl) phenyl}carbamate)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_taxid: 10026
|
|
|
Chains:
H, L
(254 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of a fviia-trypsin chimera (ft) in complex with soluble tissue factor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: kidney. Tissue: blood. Gene: f7. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: choebnalt85.
|
|
|
Chains:
L, H
(143 residues)
|
|
|
|
|
|
Factor viia in complex with the inhibitor 4-{[(r)-[5-ethoxy-2-fluoro- 3-(propan-2-yloxy)phenyl](4-phenyl-1h-imidazol-2-yl) methyl]amino}benzenecarboximidamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_taxid: 10026
|
|
|
Chains:
H, L
(254 residues)
CATH domains:
|
|
|
|
|
|
Factor viia in complex with the inhibitor 2-(2-{(r)-[(4- carbamimidoylphenyl)amino][5-ethoxy-2-fluoro-3-(propan-2-yloxy) phenyl]methyl}-1h-imidazol-4-yl)benzamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_taxid: 10026
|
|
|
Chains:
H, L
(254 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of a fviia-trypsin chimera (yt) in complex with soluble tissue factor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: kidney. Tissue: blood. Gene: f7. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: choebnalt85.
|
|
|
Chains:
L, H
(94 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of a fviia-trypsin chimera (st) in complex with soluble tissue factor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: kidney. Tissue: blood. Gene: f7. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: choebnalt85.
|
|
|
Chains:
L, H
(141 residues)
|
|
|
|
|
|
Factor viia in complex with the inhibitor n-{3-[(2r)-1-{(2r)-2-[(1- aminoisoquinolin-6-yl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-4- (propan-2-ylsulfonyl)phenyl}acetamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_taxid: 10026
|
|
|
Chains:
H, L
(254 residues)
CATH domains:
|
|
|
|
|
|
Factor viia in complex with the inhibitor (2r)-2-[(1-aminoisoquinolin- 6-yl)amino]-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7, 9,16,19-hexaene-3,12-dione
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_taxid: 10026
|
|
|
Chains:
H, L
(250 residues)
CATH domains:
|
|
|
|
|
|
Factor viia in complex with the inhibitor (2r,15r)-2-[(1- aminoisoquinolin-6-yl)amino]-8-fluoro-7-hydroxy-4,15,17-trimethyl-13- oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19- hexaene-3,12-dione
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_taxid: 10026
|
|
|
Chains:
H, L
(254 residues)
CATH domains:
|
|
|
|
|
|
Mouse pofut1 in complex with mouse factor vii egf1 and gdp
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: pofut1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293s gnti-. Gene: f7, cf7. Expressed in: escherichia coli.
|
|
|
Chain:
B
(38 residues)
|
|
|
|
|
|
Mouse pofut1 in complex with o-glucosylated mouse factor vii egf1 and gdp
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: pofut1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: f7, cf7. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
B
(40 residues)
|
|
|
|
|
|
Mouse pofut1 in complex with mouse factor vii egf1 mutant (t101a) and gdp-fucose
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: pofut1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: f7, cf7. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
B
(37 residues)
|
|
|
|
|
|
Human poglut1 in complex with factor vii egf1 and udp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: poglut1, c3orf9, clp46, ktelc1, mdsrp, mds010, unq490/pro1006. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293s gnti-. Gene: f7. Expressed in: escherichia coli bl21(de3).
|
|
|
Chain:
B
(39 residues)
|
|
|
|
|
|
Factor viia in complex with the inhibitor 1-[(2r,15r)-2-[(1-amino-4- fluoroisoquinolin-6-yl)amino]-4,15,20-trimethyl-3,12-dioxo-13-oxa-4, 11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6,8,10(21),16,19- hexaen-7-yl] cyclobutane-1-carboxylic acid
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_taxid: 10026
|
|
|
Chains:
H, L
(254 residues)
CATH domains:
|
|
|
|
|
|
Factor viia in complex with the inhibitor 1-[(2r,15r)-2-[(1-amino-4- fluoroisoquinolin-6-yl)amino]-4,15,17-trimethyl-3,12-dioxo-13-oxa-4, 11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19- hexaen-7-yl]cyclohexane-1-carboxylic acid
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_taxid: 10026
|
|
|
Chains:
H, L
(254 residues)
CATH domains:
|
|
|
|
|
|
Factor viia in complex with the inhibitor (2r,15r)-2-[(1- aminoisoquinolin-6-yl)amino]-4,15,17-trimethyl-7-[1-(1h-tetrazol-5- yl)cyclopropyl]-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa- 1(18),6(21),7,9,16,19-hexaene-3,12-dione
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_taxid: 10026
|
|
|
Chains:
H, L
(251 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of factor viia in complex with cyclohexanamine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, C
(58 residues)
|
|
|
|
|
|
Crystal structure of factor viia in complex with phenylmethanamine;hydrochloride
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, C
(58 residues)
|
|
|
|
|
|
Crystal structure of factor viia in complex with cyclohexylmethanamine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, C
(58 residues)
|
|
|
|
|
|
Crystal structure of factor viia in complex with 1-[[3-[2-hydroxy-3- (1h-pyrrolo[3,2-c]pyridin-2-yl)phenyl]phenyl]methyl]-3-phenylurea
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
H, L
(248 residues)
|
|
|
|
|
|
Human factor viia in complex with 5-hydroxy-n-(4-oxo-3h-quinazolin-6- yl)-1-[3-[(phenylcarbamoylamino)methyl]phenyl]pyrazole-4-carboxamide at 1.50a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(57 residues)
|
|
|
|
|
|
Crystal structure of factor viia in complex with (2s)-2-hydroxy-n-[[3- [5-hydroxy-4-(1h-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1- yl]phenyl]methyl]propanamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(56 residues)
|
|
|
|
|
|
Crystal structure of factor viia in complex with n-(2-amino-1h- benzimidazol-5-yl)-2-[3-[(2-amino-2-oxoethyl)-methylsulfonylamino]-5- chlorophenyl]acetamide;2,2,2-trifluoroacetic acid
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(58 residues)
|
|
|
|
|
|
Crystal structure of factor viia in complex with (2r)-2-hydroxy-n-[[3- [5-hydroxy-4-(1h-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1- yl]phenyl]methyl]-3-methylbutanamide;hydrobromide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(57 residues)
|
|
|
|
|
|
Human factor viia in complex with n-(2-amino-1h-benzimidazol-5-yl)-1- [3-[[(3,5-dimethyl-1,2-oxazol-4-yl)carbamoylamino]methyl]phenyl]-5- hydroxypyrazole-4-carboxamide at 1.73a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(57 residues)
|
|
|
|
|
|
Crystal structure of factor viia in complex with 1-(1- aminoisoquinolin-6-yl)-3-benzylurea
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(56 residues)
|
|
|
|
|
|
Crystal structure of factor viia in complex with n-[[4-(aminomethyl)- 2-(2-amino-2-oxoethoxy)phenyl]methyl]-2-(4-hydroxyphenyl)-2- methoxyacetamide;hydrochloride
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, C
(57 residues)
|
|
|
|
|
|
Crystal structure of factor viia in complex with 2-[(1- aminoisoquinolin-6-yl)amino]-2-(5-ethoxy-2-fluorophenyl)-1-(2- phenylpyrrolidin-1-yl)ethanone
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(58 residues)
|
|
|
|
|
|
Crystal structure of factor viia in complex with 5-hydroxy-n-(3-oxo-1, 2-dihydroisoindol-5-yl)-1-[3-[(phenylcarbamoylamino) methyl]phenyl]pyrazole-4-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(57 residues)
|
|
|
|
|
|
Crystal structure of factor viia in complex with (2s)-2,3-dihydroxy-n- [[3-[5-hydroxy-4-(1h-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1- yl]phenyl]methyl]propanamide;hydrobromide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, C
(56 residues)
|
|
|
|
|
|
Crystal structure of factor viia in complex with 2-[(1- aminoisoquinolin-6-yl)amino]-2-(3-ethoxy-4-propan-2-yloxyphenyl)-1- (2-phenylpyrrolidin-1-yl)ethanone
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(58 residues)
|
|
|
|
|
|
Crystal structure of factor viia in complex with 1h-benzimidazol-2- amine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, C
(58 residues)
|
|
|
|
|
|
Crystal structure of factor viia in complex with (2s)-2-hydroxy-n-[[3- [5-hydroxy-4-(1h-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1- yl]phenyl]methyl]-3-phenylpropanamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, C
(58 residues)
|
|
|
|
|
|
Crystal structure of factor viia in complex with n-(2-amino-1h- benzimidazol-5-yl)-2-(3-chlorophenyl)acetamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(58 residues)
|
|
|
|
|
|
Crystal structure of factor viia in complex with n-(2-amino-1h- benzimidazol-5-yl)-2-[3-[(2-amino-2-oxoethyl)- methylsulfonylamino]phenyl]acetamide;2,2,2-trifluoroacetic acid
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, C
(58 residues)
|
|
|
|
|
|
Crystal structure of factor viia in complex with n-(6-aminopyridin-3- yl)-5-hydroxy-1-phenylpyrazole-4-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, C
(58 residues)
|
|
|
|
|
|
Crystal structure of factor viia in complex with isoquinoline-1,6- diamine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(56 residues)
|
|
|
|
|
|
Crystal structure of factor viia in complex with 1-(2,6- difluorophenyl)-3-[[3-[5-hydroxy-4-(1h-pyrrolo[3,2-c]pyridin-2-yl) pyrazol-1-yl]phenyl]methyl]urea
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, C
(58 residues)
|
|
|
|
|
|
Crystal structure of factor viia in complex with 1-[[3-[5-hydroxy-4- (1h-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]-3- phenylurea
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, C
(58 residues)
|
|
|
|
|
|
Crystal structure of factor viia in complex with 2-(4-ethoxy-3- methoxyphenyl)-2-(isoquinolin-6-ylamino)acetic acid
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(56 residues)
|
|
|
|
|
|
Crystal structure of factor viia in complex with benzenecarboximidamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, D
(56 residues)
|
|
|
|
|
|
Crystal structure of factor viia in complex with 2-phenyl-4-(1h- pyrrolo[3,2-c]pyridin-2-yl)pyrazol-3-ol
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, C
(58 residues)
|
|
|
|
|
|
Crystal structure of factor viia in complex with 1-[[3-[4-(5-amino-1h- pyrrolo[3,2-b]pyridin-2-yl)-5-hydroxypyrazol-1-yl]phenyl]methyl]-3- phenylurea
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, C
(58 residues)
|
|
|
|
|
|
Human factor viia in complex with 1-[[3-[5-hydroxy-3-methyl-4-(1h- pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]-3-phenylurea at 2.43a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, C
(57 residues)
|
|
|
|
|
|
Human factor viia in complex with 1-[[3-[5-hydroxy-4-(7h-pyrrolo[2,3- d]pyrimidin-6-yl)pyrazol-1-yl]phenyl]methyl]-3-phenylurea at 1.84a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(57 residues)
|
|
|
|
|
|
Crystal structure of factor viia in complex with n-[[3-[5-hydroxy-4- (1h-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]pentanamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, C
(58 residues)
|
|
|
|
|
|
Factor viia in complex with the inhibitor (5r)-5-[(1-aminoisoquinolin- 6-yl)amino]-19-(cyclopropylsulfonyl)-3-methyl-13-oxa-3,15- diazatricyclo[14.3.1.1~6,10~]henicosa-1(20),6(21),7,9,16,18-hexaene- 4,14-dione
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_taxid: 10026
|
|
|
Chains:
H, L
(252 residues)
|
|
|
|
|
|
Factor viia in complex with the inhibitor (11r)-11-[(1- aminoisoquinolin-6-yl)amino]-16-(cyclopropylsulfonyl)-13-methyl-2,13- diazatricyclo[13.3.1.1~6,10~]icosa-1(19),6(20),7,9,15,17-hexaene-3, 12-dione
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_taxid: 10026
|
|
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Chains:
H, L
(250 residues)
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Factor viia in complex with the inhibitor (5r,11r)-11-[(1-amino-4- fluoroisoquinolin-6-yl)amino]-16-(cyclopropylsulfonyl)-7-(2,2- difluoroethoxy)-5,13-dimethyl-2,13-diazatricyclo[13.3.1.1~6, 10~]icosa-1(19),6(20),7,9,15,17-hexaene-3,12-dione
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_taxid: 10026
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Chains:
H, L
(250 residues)
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Factor viia in complex with the inhibitor 3-{[(2r)-17-ethyl-4-methyl- 3,12-dioxo-7-[(propan-2-yl)sulfonyl]-13-oxa-4,11- diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaen-2- yl]amino}benzamide
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_taxid: 10026
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Chains:
H, L
(251 residues)
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Crystal structure of the super-active fviia variant vyt in complex with tissue factor
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Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: kidney. Tissue: blood. Gene: f7. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: choebnalt85.
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Chains:
L, H
(143 residues)
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Factor vii binding fab of the bispecific antibody hmb-001 in complex with factor vii
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Source: Homo sapiens. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Human. Gene: f7. Gene: f3. Expression_system_taxid: 9606
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Chains:
C, D, H, I, M, N, R, S
(254 residues)
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Crystal structure of fviia in complex with a benzamidine-based inhibitor
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_cell_line: bhk/vp16. Gene: f3. Expressed in: escherichia coli.
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Chains:
A, B
(141 residues)
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Crystal structure of fviia in complex with a benzamidine-based inhibitor
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_cell_line: bhk/vp16. Gene: f3. Expressed in: escherichia coli.
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Chains:
A, B
(141 residues)
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Bcx2627 complexed with human fviia and soluble tissue factor.
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetinae. Expression_system_taxid: 10026. Expression_system_cell_line: bhk. Gene: f3. Expressed in: unidentified baculovirus.
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Chains:
L, H
(142 residues)
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Nanodisc-embedded human tf/fviia/xk1 in complex with 10h10 fab (nanodisc-subtracted)
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Gene: f10. Expression_system_atcc_number: crl-1573.
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Chains:
V, S
(142 residues)
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[IntEnz]
[ExPASy]
[KEGG]
