_EC 3.1.3.108 nocturnin.

4 PDB entries

EC 3.-.-.- Hydrolases. [52,146 PDB entries] EC 3.1.-.- Acting on ester bonds. [12,910 PDB entries] EC 3.1.3.- Phosphoric monoester hydrolases. [3,608 PDB entries] EC 3.1.3.108 nocturnin. [4 PDB entries]

6bt1

Reaction:		(1) Nadph + H2O = phosphate + nadh. (2) NADP(+) + H2O = phosphate + NAD(+).
		NADPH + H2O = phosphate + NADH NADP(+) + H2O = phosphate + NAD(+) Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Other name(s):		nocturnin (curled).
Comments:		The mammalian mitochondrial enzyme is a rhythmically expressed protein that regulates metabolism under the control of circadian clock. It has a slight preference for Nadph over NADP(+). The archaeal enzyme, identified in Methanocaldococcus jannaschii, is bifunctional acting as Nad kinase (EC 2.7.1.23) and Nadp phosphatase with a slight preference for NADP(+) over Nadph.
Links:		[IntEnz]   [ExPASy]   [KEGG]

There are 4 PDB entries in enzyme class E.C.3.1.3.108

PDB code		Protein
6bt1		Structure of the human nocturnin catalytic domain Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: noct, ccr4, ccrn4l, noc. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2. Chain: A (296 residues)
6bt2		Structure of the human nocturnin catalytic domain with bound sulfate anion Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: noct, ccr4, ccrn4l, noc. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta 2. Chains: A, B (270 residues)
6mal		Structure of human nocturnin c-terminal domain Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: noct, ccr4, ccrn4l, noc. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008 Chain: A (303 residues)
6nf0		Nocturnin with bound NADPH substrate Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: noct, ccr4, ccrn4l, noc. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (298 residues) Bound ligands:   Het Group NDP corresponds to enzyme reactant NADPH   Het Group NDP corresponds to enzyme reactant NADP(+)