_EC 3.1.13.4 poly(A)-specific ribonuclease. 44 PDB entries  
EC 3.-.-.- Hydrolases. [52,127 PDB entries]
EC 3.1.-.- Acting on ester bonds. [12,902 PDB entries]
EC 3.1.13.- Exoribonucleases producing 5'-phosphomonoesters. [1,717 PDB entries]
EC 3.1.13.4 poly(A)-specific ribonuclease. [44 PDB entries]
1ug8

Reaction: Exonucleolytic cleavage of poly(A) to 5'-AMP.
Comments: Cleaves poly(A) in either the single- or double-stranded form.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 44 PDB entries in enzyme class E.C.3.1.13.4

  PDB code Protein
1ug8
Nmr structure of the r3h domain from poly(a)-specific ribonuclease
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: riken cdna 1200003i18. Other_details: cell-free protein synthesis
Chain: A (87 residues) CATH domain: 3.30.1370.50
1uoc
X-ray structure of the rnase domain of the yeast pop2 protein
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (263 residues) CATH domain: 3.30.420.10
1whv
Solution structure of the RNA binding domain from hypothetical protein bab23382
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: riken cdna 1200003i18. Other_details: cell-free protein synthesis
Chain: A (100 residues) CATH domain: 3.30.70.330
2a1r
Crystal structure of parn nuclease domain
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: parn. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (300 residues) CATH domain: 3.30.420.10
2a1s
Crystal structure of native parn nuclease domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (391 residues) CATH domains: 3.30.420.10 3.30.1370.50
2d5r
Crystal structure of a tob-hcaf1 complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (252 residues) CATH domain: 3.30.420.10
2p51
Crystal structure of the s. Pombe pop2p deadenylation subunit
Source: Schizosaccharomyces pombe. Fission yeast. Organism_taxid: 4896. Gene: spcc18.06c (caf1 homologue). Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (255 residues) CATH domain: 3.30.420.10
2rok
Solution structure of the cap-binding domain of parn complexed with the cap analog
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: parn
Chain: A (100 residues)
3ctr
Crystal structure of the rrm-domain of the poly(a)-specific ribonuclease parn bound to m7gtp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: parn, dan. Expressed in: escherichia coli.
Chain: A (75 residues) CATH domain: 3.30.70.330
3d45
Crystal structure of mouse parn in complex with m7gpppg
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: parn. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (383 residues) CATH domain: 3.30.420.10
3g0z
Structure of s. Pombe pop2p - zn2+ and mn2+ bound form
Source: Schizosaccharomyces pombe. Fission yeast. Organism_taxid: 4896. Gene: caf1, spcc18.06c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (252 residues) CATH domain: 3.30.420.10
3g10
Structure of s. Pombe pop2p - mg2+ and mn2+ bound form
Source: Schizosaccharomyces pombe. Fission yeast. Organism_taxid: 4896. Gene: caf1, spcc18.06c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (252 residues) CATH domain: 3.30.420.10
3ngn
Crystal structure of the human cnot6l nuclease domain in complex with amp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cnot6l, ccr4b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (324 residues) CATH domain: 3.60.10.10
3ngo
Crystal structure of the human cnot6l nuclease domain in complex with poly(a) DNA
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cnot6l, ccr4b. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (337 residues) CATH domain: 3.60.10.10
3ngq
Crystal structure of the human cnot6l nuclease domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cnot6l, ccr4b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (335 residues) CATH domain: 3.60.10.10
4b8a
Structure of yeast not1 mif4g domain co-crystallized with caf1
Source: Saccharomyces cerevisiae s288c. Baker's yeast. Organism_taxid: 559292. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: plyss star. Expression_system_variant: plys star.
Chain: B (252 residues) CATH domain: 3.30.420.10
4b8c
Nuclease module of the yeast ccr4-not complex
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: s288c. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Saccharomyces cerevisiae s288c. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, C, D, E, F, J, K, L (267 residues) CATH domain: 3.30.420.10
4cyj
Chaetomium thermophilum pan2:pan3 complex
Source: Chaetomium thermophilum. Organism_taxid: 209285. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: see publication for full details. Other_details: see publication for details
Chains: E, F (52 residues)
4czv
Structure of the neurospora crassa pan2 wd40 domain
Source: Neurospora crassa. Organism_taxid: 5141. Atcc: 24698. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.
Chains: A, B (324 residues) CATH domain: 2.130.10.10
4czw
Structure of the neurospora crassa pan2 catalytic unit (protease and nuclease domain)
Source: Neurospora crassa. Organism_taxid: 5141. Atcc: 24698. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.
Chain: A (609 residues) CATH domain: 3.90.70.10
4czx
Complex of neurospora crassa pan2 (wd40) with pan3 (c-term)
Source: Neurospora crassa. Organism_taxid: 5141. Atcc: 24698. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.
Chain: A (324 residues) CATH domain: 2.130.10.10
4czy
Complex of neurospora crassa pan2 (wd40-cs1) with pan3 (pseudokinase and c-term)
Source: Neurospora crassa. Organism_taxid: 5141. Atcc: 24698. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.
Chains: A, C (323 residues) CATH domain: 2.130.10.10
4d0k
Complex of chaetomium thermophilum pan2 (wd40-cs1) with pan3 (c-term)
Source: Chaetomium thermophilum. Organism_taxid: 209285. Strain: dsm 1495. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.
Chain: A (329 residues) CATH domain: 2.130.10.10
4gmj
Structure of human not1 mif4g domain co-crystallized with caf1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ad-005, cdc39, cnot1, kiaa1007, not1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: caf1, cnot7.
Chains: B, D, F (264 residues) CATH domain: 3.30.420.10
4q8g
Structure of the saccharomyces cerevisiae pan2 pseudoubiquitin- hydrolase
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: pan2, ygl094c. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (344 residues) CATH domain: 3.90.70.10
4q8h
Structure of the saccharomyces cerevisiae pan2 pseudoubiquitin- hydrolase-rnase module
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: pan2, ygl094c. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chain: A (627 residues) CATH domain: 3.90.70.10
4xr7
Structure of the saccharomyces cerevisiae pan2-pan3 core complex
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: pan2, ygl094c. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: pan3, ecm35, ykl025c. Expression_system_taxid: 7111
Chains: G, D, J, A (683 residues) CATH domain: 3.90.70.10
4z0v
The structure of human pde12 residues 161-609
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde12. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: de3
Chain: A (434 residues)
4z2b
The structure of human pde12 residues 161-609 in complex with gsk3036342a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde12. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: de3
Chain: A (449 residues)
4zkf
Crystal structure of human phosphodiesterase 12
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde12. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (462 residues)
5dv2
Crystal structure of human cnot6l in complex with cytidine-5'- monophosphate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cnot6l, ccr4b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (335 residues) CATH domain: 3.60.10.10
5dv4
Crystal structure of human cnot6l in complex with neomycin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cnot6l, ccr4b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (344 residues) CATH domain: 3.60.10.10
6r5k
Cryo-em structure of a poly(a) rnp bound to the pan2-pan3 deadenylase
Source: Saccharomyces cerevisiae (strain atcc 204508 / s288c). Baker's yeast. Organism_taxid: 559292. Gene: pan2, ygl094c. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: hi5. Gene: pab1, yer165w.
Chain: A (1040 residues)
6r9i
Structure of saccharomyces cerevisiae apo pan2 pseudoubiquitin hydrolase-RNA exonuclease (uch-exo) module
Source: Saccharomyces cerevisiae s288c. Baker's yeast. Organism_taxid: 559292. Gene: pan2, ygl094c. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (605 residues)
6r9j
Structure of saccharomyces cerevisiae apo pan2 pseudoubiquitin hydrolase-RNA exonuclease (uch-exo) module in complex with a7 RNA
Source: Saccharomyces cerevisiae (strain atcc 204508 / s288c). Organism_taxid: 559292. Gene: pan2, ygl094c. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Saccharomyces cerevisiae. Baker's yeast.
Chain: A (595 residues)
6r9m
Structure of saccharomyces cerevisiae apo pan2 pseudoubiquitin hydrolase-RNA exonuclease (uch-exo) module in complex with aaggaa rna
Source: Saccharomyces cerevisiae s288c. Organism_taxid: 559292. Gene: pan2, ygl094c. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932.
Chain: A (600 residues)
6r9o
Structure of saccharomyces cerevisiae apo pan2 pseudoubiquitin hydrolase-RNA exonuclease (uch-exo) module in complex with aagga RNA
Source: Saccharomyces cerevisiae s288c. Organism_taxid: 559292. Gene: pan2, ygl094c. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932.
Chain: A (594 residues)
6r9p
Structure of saccharomyces cerevisiae apo pan2 pseudoubiquitin hydrolase-RNA exonuclease (uch-exo) module in complex with aauuaa rna
Source: Saccharomyces cerevisiae (strain atcc 204508 / s288c). Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Gene: pan2, ygl094c. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes.
Chain: A (607 residues)
6r9q
Structure of saccharomyces cerevisiae apo pan2 pseudoubiquitin hydrolase-RNA exonuclease (uch-exo) module in complex with aaccaa rna
Source: Saccharomyces cerevisiae s288c. Organism_taxid: 559292. Gene: pan2, ygl094c. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932.
Chain: A (610 residues)
7ax1
Crystal structure of the human ccr4-caf1 complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cnot6, ccr4, ccr4a, kiaa1194. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star. Gene: cnot7, caf1.
Chains: A, B (518 residues)
7voi
Structure of the human cnot1(mif4g)-cnot6l-cnot7 complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cnot7, caf1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: cnot1, cdc39, kiaa1007, not1, ad-005. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: B, C (264 residues)
9e7t
Cryo-em structure of not1:not7:pief
Source: Legionella pneumophila. Organism_taxid: 446. Gene: pief, jbj86_12865. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: cnot1, cdc39, kiaa1007, not1, ad-005.
Chain: C (254 residues)
9e7u
Cryo-em structure of not1:not8:pief
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: smt3, ydr510w, d9719.15, cnot8, calif, pop2. Expressed in: escherichia coli. Expression_system_taxid: 562. Legionella pneumophila. Organism_taxid: 446. Gene: pief, jbj86_12865.
Chain: C (258 residues)
9qtu
Human pan2-pan3 deadenylase complex in the apo state
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pan3. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293-t. Gene: pan2, kiaa0710, usp52.
Chain: C (401 residues)