_EC 2.7.11.30 receptor protein serine/threonine kinase. 184 PDB entries  
EC 2.-.-.- Transferases. [47,771 PDB entries]
EC 2.7.-.- Transferring phosphorus-containing groups. [28,096 PDB entries]
EC 2.7.11.- Protein-serine/threonine kinases. [7,393 PDB entries]
EC 2.7.11.30 receptor protein serine/threonine kinase. [184 PDB entries]
1b6c

Reaction: (1) L-seryl-[receptor-protein] + Atp = O-phospho-L-seryl-[receptor- protein] + Adp + H(+). (2) L-threonyl-[receptor-protein] + Atp = O-phospho-L-threonyl-[receptor- protein] + Adp + H(+).
 

L-seryl-[receptor-protein]
 +
ATP
 = O-phospho-L-seryl-[receptor- protein]
 +
ADP
 + H(+)
L-threonyl-[receptor-protein]
 +
ATP
 = O-phospho-L-threonyl-[receptor- protein]
 +
ADP
 + H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): activin receptor kinase. receptor serine/threonine protein kinase. receptor type Ii serine/threonine protein kinase. receptor type I serine/threonine protein kinase. TGF-beta kinase.
Comments: The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. Signaling occurs by the binding of ligand to the type Ii receptor, which is the constitutively active kinase. Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. Formerly Ec 2.7.1.37.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 184 PDB entries in enzyme class E.C.2.7.11.30

  PDB code Protein
1b6c
Crystal structure of the cytoplasmic domain of the type i tgf-beta receptor in complex with fkbp12
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: plys s. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, D, F, H (326 residues) CATH domains: 3.30.200.20 1.10.510.10
1bte
Crystal structure of the extracellular domain of the type ii activin receptor
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chains: A, B (92 residues) CATH domain: 2.10.60.10
Bound ligand:   Het Group NAG is 41.38% similar to enzyme product ADP
1es7
Complex between bmp-2 and two bmp receptor ia ectodomains
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, D (83 residues) CATH domain: 2.10.60.10
1ias
Cytoplasmic domain of unphosphorylated type i tgf-beta receptor crystallized without fkbp12
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B, C, D, E (330 residues) CATH domains: 3.30.200.20 1.10.510.10
1ks6
Transforming growth factor beta type ii receptor ligand binding domain
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (107 residues) CATH domain: 2.10.60.10
1ktz
Crystal structure of the human tgf-beta type ii receptor extracellular domain in complex with tgf-beta3
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chain: B (106 residues) CATH domain: 2.10.60.10
1lx5
Crystal structure of the bmp7/actrii extracellular domain complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmp7. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: ovary cells. Other_details: dhfr-. Mus musculus.
Chain: B (94 residues) CATH domain: 2.10.60.10
Bound ligands:   Het Group NAG is 41.38% similar to enzyme product ADP
  Het Group NAG is 41.38% similar to enzyme product ADP
1m9z
Crystal structure of human tgf-beta type ii receptor ligand binding domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (105 residues) CATH domain: 2.10.60.10
1nys
Crystal structure of activin a bound to the ecd of actriib p41
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: actriib. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Human. Organism_taxid: 9606.
Chains: A, C (91 residues) CATH domain: 2.10.60.10
1nyu
Crystal structure of activin a bound to the ecd of actriib
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: actriib. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Human. Organism_taxid: 9606.
Chains: A, C (92 residues) CATH domain: 2.10.60.10
1plo
Transforming growth factor-beta type ii receptor extracellular domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (122 residues) CATH domain: 2.10.60.10
1py5
Crystal structure of tgf-beta receptor i kinase with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (301 residues) CATH domains: 3.30.200.20 1.10.510.10
1rew
Structural refinement of the complex of bone morphogenetic protein 2 and its type ia receptor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: C, D (86 residues) CATH domain: 2.10.60.10
1rw8
Crystal structure of tgf-beta receptor i kinase with atp site inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tru. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (301 residues) CATH domains: 3.30.200.20 1.10.510.10
1s4y
Crystal structure of the activin/actriib extracellular domain
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: acvr2b. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606.
Chains: A, C (91 residues) CATH domain: 2.10.60.10
1vjy
Crystal structure of a naphthyridine inhibitor of human tgf-beta type i receptor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (299 residues) CATH domains: 3.30.200.20 1.10.510.10
2goo
Ternary complex of bmp-2 bound to bmpr-ia-ecd and actrii-ecd
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmp2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: bmpr1a. Mus musculus. House mouse.
Chains: B, C, E, F (85 residues) CATH domain: 2.10.60.10
Bound ligand:   Het Group NDG is 40.00% similar to enzyme product ADP
2h62
Crystal structure of a ternary ligand-receptor complex of bmp-2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmp2, bmp2a. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: bmpr1a, acvrlk3, alk3. Expression_system_taxid: 562
Chains: C, D (84 residues) CATH domain: 2.10.60.10
2h64
Crystal structure of a ternary ligand-receptor complex of bmp-2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmp2, bmp2a. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: bmpr1a, acvrlk3, alk3. Mus musculus. House mouse.
Chains: B, C (92 residues) CATH domain: 2.10.60.10
2hlq
Crystal structure of the extracellular domain of the type ii bmp receptor
Source: Ovis aries. Sheep. Organism_taxid: 9940. Gene: bmprii. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (100 residues) CATH domain: 2.10.60.10
2hlr
Crystal structure of the extracellular domain of the type ii bmp receptor
Source: Ovis aries. Sheep. Organism_taxid: 9940. Gene: bmprii. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (67 residues) CATH domain: 2.10.60.10
2k3g
Nmr structure analysis of a bmp receptor
Source: Homo sapiens. Gene: bmpr1a, acvrlk3, alk3. Expressed in: escherichia coli.
Chain: A (102 residues) CATH domain: 2.10.60.10
2l5s
Solution structure of the extracellular domain of the tgf-beta type i receptor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (88 residues) CATH domain: 2.10.60.10
2lcr
Nmr structure of alk1 extracellular domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvrl1, acvrlk1, alk1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (97 residues) CATH domain: 2.10.60.10
2pjy
Structural basis for cooperative assembly of the tgf-beta signaling complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfb3. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: tgfbr2. Gene: tgfbr1. Expression_system_taxid: 562
Chains: B, C (108 residues) CATH domain: 2.10.60.10
2qj9
Crystal structure analysis of bmp-2 in complex with bmpr-ia variant b1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmp2, bmp2a. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: bmpr1a, acvrlk3, alk3.
Chains: D, C (93 residues) CATH domain: 2.10.60.10
2qja
Crystal structure analysis of bmp-2 in complex with bmpr-ia variant b12
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmp2, bmp2a. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: bmpr1a, acvrlk3, alk3.
Chains: C, D (85 residues) CATH domain: 2.10.60.10
2qjb
Crystal structure analysis of bmp-2 in complex with bmpr-ia variant ia/ib
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmp2, bmp2a. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: bmpr1a, acvrlk3, alk3.
Chains: C, D (85 residues) CATH domain: 2.10.60.10
2qlu
Crystal structure of activin receptor type ii kinase domain from human
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: A (297 residues) CATH domains: 3.30.200.20 1.10.510.10
2wot
Alk5 in complex with 4-((5,6-dimethyl-2-(2-pyridyl)-3-pyridyl)oxy)-n- (3,4,5-trimethoxyphenyl)pyridin-2-amine
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (303 residues) CATH domains: 3.30.200.20 1.10.510.10
2wou
Alk5 in complex with 4-((4-((2,6-dimethyl-3-pyridyl)oxy)-2-pyridyl) amino)benzenesulfonamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (299 residues) CATH domains: 3.30.200.20 1.10.510.10
2x7o
Crystal structure of tgfbri complexed with an indolinone inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: high five.
Chains: A, B, C, D, E (330 residues) CATH domains: 3.30.200.20 1.10.510.10
3evs
Crystal structure of the gdf-5:bmp receptor ib complex.
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: u2os. Gene: cdmp1, gdf5. Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. Mouse.
Chain: C (85 residues) CATH domain: 2.10.60.10
3faa
Crystal structure of tgfbri complexed with a 2-aminoimidazole inhibitor
Source: Homo sapiens. Organism_taxid: 9606. Cell_line: sf9. Gene: tgfbr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B, C, D, E (328 residues) CATH domains: 3.30.200.20 1.10.510.10
3g2f
Crystal structure of the kinase domain of bone morphogenetic protein receptor type ii (bmpr2) at 2.35 a resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmpr2, pph1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (305 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligands:   Het Group ADP corresponds to enzyme product ADP
  Het Group ADP corresponds to enzyme product ADP
3gxl
Alk-5 kinase complex with gw857175
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (285 residues) CATH domains: 3.30.200.20 1.10.510.10
3h9r
Crystal structure of the kinase domain of type i activin receptor (acvr1) in complex with fkbp12 and dorsomorphin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: baculovirus. Expression_system_taxid: 10469. Gene: fkbp1, fkbp12, fkbp1a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (312 residues) CATH domains: 3.30.200.20 1.10.510.10
3hmm
Structure of alk5 + gw855857
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (293 residues) CATH domains: 3.30.200.20 1.10.510.10
3kcf
Crystal structure of tgfbri complexed with a pyrazolone inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1, tgfbri. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B, C, D, E (328 residues) CATH domains: 3.30.200.20 1.10.510.10
3kfd
Ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfb1, tgfb. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_organ: ovary cells. Gene: tgfbr2. Expressed in: escherichia coli.
Chains: E, F, I, J, G, H, K, L (108 residues) CATH domain: 2.10.60.10
3mdy
Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1b (bmpr1b) in complex with fkbp12 and ldn- 193189
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmpr1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: fkbp12. Expressed in: escherichia coli.
Chains: A, C (320 residues) CATH domains: 3.30.200.20 1.10.510.10
3mtf
Crystal structure of the acvr1 kinase in complex with a 2- aminopyridine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (296 residues) CATH domains: 3.30.200.20 1.10.510.10
3my0
Crystal structure of the acvrl1 (alk1) kinase domain bound to ldn- 193189
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvrl1, acvrl1 (alk1), acvrlk1, alk1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X (296 residues) CATH domains: 3.30.200.20 1.10.510.10
3nh7
Crystal structure of the neutralizing fab fragment abd1556 bound to the bmp type i receptor ia
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: bmpr1a. Expression_system_taxid: 469008.
Chains: A, B, C, D (85 residues) CATH domain: 2.10.60.10
3oom
Crystal structure of the acvr1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor k00507
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (297 residues) CATH domains: 3.30.200.20 1.10.510.10
3q4t
Crystal structure of activin receptor type-iia (acvr2a) kinase domain in complex with dorsomorphin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr2, acvr2a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (305 residues) CATH domains: 3.30.200.20 1.10.510.10
3q4u
Crystal structure of the acvr1 kinase domain in complex with ldn- 193189
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B, C, D (298 residues) CATH domains: 3.30.200.20 1.10.510.10
3qb4
Crystal structure of a tgf-beta ligand-receptor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdmp1, gdf5. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: acvrlk3, alk3, bmpr1a.
Chains: B, D (88 residues) CATH domain: 2.10.60.10
3soc
Crystal structure of activin receptor type-iia (acvr2a) kinase domain in complex with a quinazolin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr2, acvr2a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (307 residues) CATH domains: 3.30.200.20 1.10.510.10
3tzm
Tgf-beta receptor type 1 in complex with sb431542
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1, alk5, skr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (295 residues) CATH domains: 3.30.200.20 1.10.510.10
4asx
Crystal structure of activin receptor type-iia (acvr2a) kinase domain in complex with dihydro-bauerinE C
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (310 residues) CATH domains: 3.30.200.20 1.10.510.10
4bgg
Crystal structure of the acvr1 kinase in complex with ldn-213844
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Other_details: site-directed mutagenesis
Chains: A, B, C, D (296 residues) CATH domains: 3.30.200.20 1.10.510.10
4c02
Crystal structure of human acvr1 (alk2) in complex with fkbp12.6 and dorsomorphin
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta plyss.
Chain: A (313 residues) CATH domains: 3.30.200.20 1.10.510.10
4dym
Crystal structure of the acvr1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor k00135
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (293 residues) CATH domains: 3.30.200.20 1.10.510.10
4fao
Specificity and structure of a high affinity activin-like 1 (alk1) signaling complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmp9, gdf2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Gene: acvrl1, acvrlk1, alk1. Gene: actriib, acvr2b.
Chains: C, D, E, F, I, J, K, L, O, P, Q, R, U, V, W, X, c, d, e, f, i, j, k, l (75 residues) CATH domain: 2.10.60.10
Bound ligands:   Het Group NAG is 41.38% similar to enzyme product ADP
  Het Group NAG is 41.38% similar to enzyme product ADP
4p7u
Extracellular domain of type ii transforming growth factor beta receptor in complex with ndsb-201
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (102 residues) CATH domain: 2.10.60.10
4x0m
Selection of fragments for kinase inhibitor design: decoration is key
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1, alk5, skr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (303 residues) CATH domains: 3.30.200.20 1.10.510.10
4x2f
Selection of fragments for kinase inhibitor design: decoration is key
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1, alk5, skr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (303 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligands:   Het Group 3WJ is 43.75% similar to enzyme product ADP
  Het Group 3WJ is 43.75% similar to enzyme product ADP
4x2g
Selection of fragments for kinase inhibitor design: decoration is key
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1, alk5, skr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (303 residues) CATH domains: 3.30.200.20 1.10.510.10
4x2j
Selection of fragments for kinase inhibitor design: decoration is key
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1, alk5, skr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (303 residues) CATH domains: 3.30.200.20 1.10.510.10
4x2k
Selection of fragments for kinase inhibitor design: decoration is key
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1, alk5, skr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (303 residues) CATH domains: 3.30.200.20 1.10.510.10
4x2n
Selection of fragments for kinase inhibitor design: decoration is key
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1, alk5, skr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (303 residues) CATH domains: 3.30.200.20 1.10.510.10
4xjj
Extracellular domain of type ii transforming growth factor beta receptor in complex with 2-(2-hydroxyethyl)ndsb-201
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (105 residues) CATH domain: 2.10.60.10
5e8s
Tgf-beta receptor type 1 kinase domain (wt)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1, alk5, skr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (301 residues) CATH domains: 3.30.200.20 1.10.510.10
5e8t
Tgf-beta receptor type 1 kinase domain (t204d)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1, alk5, skr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (302 residues) CATH domains: 3.30.200.20 1.10.510.10
5e8u
Tgf-beta receptor type 1 kinase domain (t204d,i211v,y249f,s280t, y282f,s287n,a350c,l352f)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1, alk5, skr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (306 residues) CATH domains: 3.30.200.20 1.10.510.10
5e8v
Tgf-beta receptor type 2 kinase domain (e431a,r433a,e485a,k488a,r493a, r495a)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (296 residues) CATH domains: 3.30.200.20 1.10.510.10
5e8w
Tgf-beta receptor type 1 kinase domain (t204d) in complex with staurosporine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1, alk5, skr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (303 residues) CATH domains: 3.30.200.20 1.10.510.10
5e8x
Tgf-beta receptor type 1 kinase domain (t204d,i211v,y249f,s280t, y282f,s287n,a350c,l352f) in complex with staurosporine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1, alk5, skr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (304 residues) CATH domains: 3.30.200.20 1.10.510.10
5e8y
Tgf-beta receptor type 2 kinase domain (e431a,r433a,e485a,k488a,r493a, r495a) in complex with staurosporine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (298 residues) CATH domains: 3.30.200.20 1.10.510.10
5e8z
Tgf-beta receptor type 1 kinase domain (t204d) in complex with 3- amino-6-[4-(2-hydroxyethyl)phenyl]-n-[4-(morpholin-4-yl)pyridin-3- yl]pyrazine-2-carboxamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1, alk5, skr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (303 residues) CATH domains: 3.30.200.20 1.10.510.10
5e90
Tgf-beta receptor type 1 kinase domain (t204d,i211v,y249f, s280t, y282f,s287n,a350c,l352f) in complex with 3-amino-6- [4-(2- hydroxyethyl)phenyl]-n-[4-(morpholin-4-yl)pyridin-3-yl]pyrazine-2- carboxamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1, alk5, skr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (303 residues) CATH domains: 3.30.200.20 1.10.510.10
5e91
Tgf-beta receptor type 2 kinase domain (e431a,r433a,e485a,k488a,r493a, r495a) in complex with 3-amino-6-[4-(2- hydroxyethyl)phenyl]-n-[4- (morpholin-4-yl)pyridin-3-yl] pyrazine-2-carboxamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (297 residues) CATH domains: 3.30.200.20 1.10.510.10
5e92
Tgf-beta receptor type 2 kinase domain (e431a,r433a,e485a,k488a,r493a, r495a) in complex with amppnp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (298 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligands:   Het Group ANP is 81.25% similar to enzyme product ADP
  Het Group ANP is 81.25% similar to enzyme product ADP
5fri
Alk5 in complex witha an n-(4-anilino-2-pyridyl)acetamide inhibitor.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (301 residues) CATH domains: 3.30.200.20 1.10.510.10
5ngv
Crystal structure of the activin receptor type-2b ligand binding domain in complex with bimagrumab fv, orthorhombic crystal form
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr2b. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: shuffle. Expression_system_variant: w3110.
Chain: A (93 residues)
5nh3
Crystal structure of the activin receptor type-2a ligand binding domain in complex with bimagrumab fv
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr2a, acvr2. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293-6e. Organism_taxid: 9606
Chains: A, B (94 residues)
Bound ligands:   Het Group NAG is 41.38% similar to enzyme product ADP
  Het Group NAG is 41.38% similar to enzyme product ADP
5nhr
Crystal structure of the activin receptor type-2b ligand binding domain in complex with bimagrumab fv, cubic crystal form
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli str. K-12 substr. W3110. Expression_system_taxid: 316407. Gene: acvr2b. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Expression_system_variant: shuffle.
Chains: C, D (90 residues)
5oxg
Crystal structure of the acvr1 (alk2) kinase in complex with ldn- 212854
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B, C, D (293 residues)
5oy6
Crystal structure of the acvr1 (alk2) kinase in complex with cyclical inhibitor od36.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_variant: sf9
Chains: A, B, C, D (291 residues)
5qik
Tgf-beta receptor type 1 kinase domain (t204d) in complex with n-{4- [3-(6-fluoropyridin-3-yl)-4-oxo-4,5,6,7-tetrahydro-1h-pyrrolo[3,2- c]pyridin-2-yl]pyridin-2-yl}acetamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1, alk5, skr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (303 residues)
5qil
Tgf-beta receptor type 1 kinase domain (t204d) in complex with n-{4- [3-(6-methoxypyridin-3-yl)-1h-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2- yl}acetamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1, alk5, skr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (303 residues)
5qim
Tgf-beta receptor type 1 kinase domain (t204d) in complex with n-{4- [3-(5-methoxypyridin-2-yl)-1h-pyrrolo[3,2-b] pyridin-2-yl]pyridin-2- yl}acetamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1, alk5, skr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (304 residues)
5qin
Tgf-beta receptor type 2 kinase domain in complex with n- {4-[3-(6- methoxypyridin-3-yl)-1h-pyrrolo[3,2-b]pyridin-2- yl]pyridin-2- yl}acetamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (295 residues)
5qtz
Tgf-beta receptor type 1 kinase domain (t204d) in complex with 6-[1- (2,2-difluoroethyl)-4-(6-methylpyridin-2-yl)-1h-imidazol-5- yl]imidazo[1,2-a]pyridine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1, alk5, skr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (303 residues)
5qu0
Tgf-beta receptor type 1 kinase domain (t204d) in complex with 6-[4- (3-chloro-4-fluorophenyl)-1-(2-hydroxyethyl)-1h-imidazol-5- yl]imidazo[1,2-b]pyridazine-3-carbonitrile
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1, alk5, skr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (306 residues)
5s75
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010913a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (283 residues)
5s76
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010916a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (283 residues)
5s77
Xchem group deposition -- crystal structure of human acvr1 in complex with xs035133b
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (283 residues)
5s78
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010934a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (285 residues)
5s79
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010910a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (284 residues)
5s7a
Xchem group deposition -- crystal structure of human acvr1 in complex with pk012456b
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (285 residues)
5s7b
Xchem group deposition -- crystal structure of human acvr1 in complex with fm000329d
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (285 residues)
5s7c
Xchem group deposition -- crystal structure of human acvr1 in complex with fm000274c
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (283 residues)
5s7d
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010923a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (284 residues)
5s7e
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010930a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (283 residues)
5s7f
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010935a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (283 residues)
5s7g
Xchem group deposition -- crystal structure of human acvr1 in complex with xs035844b
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (284 residues)
5s7h
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010914a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (284 residues)
5s7i
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010928a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (284 residues)
5s7j
Xchem group deposition -- crystal structure of human acvr1 in complex with fm000893d
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (286 residues)
5s7k
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010936a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (285 residues)
5s7l
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010943a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (286 residues)
5s7m
Xchem group deposition -- crystal structure of human acvr1 in complex with fm000275d
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (285 residues)
5s7n
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010920a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (286 residues)
5s7o
Xchem group deposition -- crystal structure of human acvr1 in complex with fm007391c
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (287 residues)
5s7p
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010937a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (283 residues)
5s7q
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010944a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (282 residues)
5s7r
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010918a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (283 residues)
5s7s
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010921a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (287 residues)
5s7t
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010926a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (284 residues)
5s7u
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010938a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (280 residues)
5s7v
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010942a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (282 residues)
5s7w
Xchem group deposition -- crystal structure of human acvr1 in complex with hm000007h
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (284 residues)
5s7x
Xchem group deposition -- crystal structure of human acvr1 in complex with fm000376d
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (283 residues)
5s7y
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010933a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (283 residues)
5s7z
Xchem group deposition -- crystal structure of human acvr1 in complex with nu074488b
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (287 residues)
5s80
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010946a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (283 residues)
5s81
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010947a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (283 residues)
5s82
Xchem group deposition -- crystal structure of human acvr1 in complex with xs035128c
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (279 residues)
5s83
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010948a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (283 residues)
5s84
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010949a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (284 residues)
5s85
Xchem group deposition -- crystal structure of human acvr1 in complex with fm000884c
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (282 residues)
5s86
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010952a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (283 residues)
5s87
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010953a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (284 residues)
5s88
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010954a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (283 residues)
5s89
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010957a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (283 residues)
5s8a
Xchem group deposition -- crystal structure of human acvr1 in complex with nu074484b
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (283 residues)
5s8b
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010960a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (284 residues)
5s9k
Xchem group deposition -- crystal structure of human acvr1 in complex with fm010955a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (281 residues)
5tx4
Derivative of mouse tgf-beta2, with a deletion of residues 52-71 and k25r, r26k, l51r, a74k, c77s, l89v, i92v, k94r t95k, i98v single amino acid substitutions, bound to human tgf-beta type ii receptor ectodomain residues 15-130
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: tgfb2. Expression_system_taxid: 562
Chain: A (107 residues)
5ty4
Microed structure of a complex between monomeric tgf-b and its receptor, tbrii, at 2.9 a resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr2. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chain: A (101 residues)
5usq
Alk-5 kinase inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1, alk5, skr4. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
Chain: A (299 residues)
6acr
Crystal structure of human alk2 kinase domain with r206h mutation in complex with rk-59638
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (294 residues)
6b8y
Tgf-beta receptor type 1 kinase domain (t204d) in complex with n-(3- fluoropyridin-4-yl)-2-[6-(trifluoromethyl)pyridin-2-yl]-7h-pyrrolo[2, 3-d]pyrimidin-4-amine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1, alk5, skr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (305 residues)
6eix
Crystal structure of the kinase domain of the q207e mutant of acvr1 (alk2) in complex with a 2-aminopyridine inhibitor k02288
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (312 residues)
6gi6
Crystal structure of the acvr1 (alk2) kinase in complex with a quinazolinone based alk2 inhibitor with a 5-methyl core.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (298 residues)
6gin
Crystal structure of the acvr1 (alk2) kinase in complex with an quinazolinone based alk2 inhibitor with a 4-morpholinophenyl solvent accessible group.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
Chains: A, B (296 residues)
6gip
Crystal structure of the acvr1 (alk2) kinase in complex with a quinazolinone based alk2 inhibitor with a 2, 5-dimethyl core.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
Chain: A (296 residues)
6i1s
Crystal structure of the acvr1 (alk2) kinase in complex with fkbp12 and the inhibitor e6201
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_variant: sf9. Gene: fkbp1a, fkbp1, fkbp12. Expressed in: escherichia coli bl21(de3).
Chain: A (322 residues)
6jux
Crystal structure of human alk2 kinase domain with r206h mutation in complex with rk-71807
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (295 residues)
6mac
Ternary structure of gdf11 bound to actriib-ecd and alk5-ecd
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gdf11, bmp11. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Rattus norvegicus. Rat. Organism_taxid: 10116.
Chains: C, K (95 residues)
Bound ligands:   Het Group NAG is 41.38% similar to enzyme product ADP
  Het Group NAG is 41.38% similar to enzyme product ADP
6sf1
Bone morphogenetic protein 10 (bmp10) complexed with extracellular domain of activin receptor-like kinase 1 (alk1).
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvrl1, acvrlk1, alk1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: bmp10. Expressed in: homo sapiens. Expression_system_taxid: 9606.
Chain: A (76 residues)
6sf2
Ternary complex of human bone morphogenetic protein 9 (bmp9) growth factor domain, its prodomain and extracellular domain of activin receptor-like kinase 1 (alk1).
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvrl1, acvrlk1, alk1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: gdf2, bmp9. Expressed in: homo sapiens. Expression_system_taxid: 9606.
Chains: A, D (75 residues)
Bound ligands:   Het Group NAG is 41.38% similar to enzyme product ADP
  Het Group NAG is 41.38% similar to enzyme product ADP
6sf3
Bone morphogenetic protein 10 (bmp10) in complex with extracellular domain of activin receptor-like kinase 1 (alk1) at 2.3 angstrom
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvrl1, acvrlk1, alk1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: bmp10. Expressed in: homo sapiens. Expression_system_taxid: 9606.
Chain: A (76 residues)
6srh
Crystal structure of the acvr1 (alk2) kinase in complex with the compound m4k2117
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
Chains: A, B (288 residues)
6szm
Crystal structure of the acvr1 (alk2) kinase in complex with the compound m4k2009
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
Chains: A, B (288 residues)
6t6d
Crystal structure of the acvr1 (alk2) kinase in complex with the compound m4k2149
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
Chains: A, B, C, D (292 residues)
6t8n
Crystal structure of the acvr1 (alk2) kinase in complex with the compound m4k3007
Source: Homo sapiens. Organism_taxid: 9606. Gene: acvr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (293 residues)
6tn8
Crystal structure of the acvr1 (alk2) kinase in complex with the compound bi-9564
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
Chain: A (296 residues)
6unp
Crystal structure of the kinase domain of bmpr2-d485g
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmpr2, pph1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (302 residues)
Bound ligands:   Het Group ADP corresponds to enzyme product ADP
  Het Group ADP corresponds to enzyme product ADP
6unq
Kinase domain of alk2-k493a with amppnp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (289 residues)
Bound ligands:   Het Group ANP is 81.25% similar to enzyme product ADP
  Het Group ANP is 81.25% similar to enzyme product ADP
6unr
Kinase domain of alk2-k492a/k493a with amppnp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (286 residues)
Bound ligands:   Het Group ANP is 81.25% similar to enzyme product ADP
  Het Group ANP is 81.25% similar to enzyme product ADP
6uns
Kinase domain of alk2-k492a/k493a with ldn-193189
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (288 residues)
6z36
Crystal structure of the acvr1 (alk2) kinase in complex with the compound m4k2118
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
Chains: A, B (286 residues)
6zgc
Crystal structure of the acvr1 (alk2) kinase in complex with the compound saracatinib (azd0530)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
Chains: A, B, C, D (292 residues)
7a21
Crystal structure of the acvr1 (alk2) kinase in complex with the compound m4k2158
Source: Homo sapiens. Organism_taxid: 9606. Gene: acvr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
Chains: A, B (296 residues)
7c3g
Crystal structure of human alk2 kinase domain with r206h mutation in complex with a bicyclic pyrazole inhibitor rk-73134
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (294 residues)
7dv6
Discovery of functionally selective transforming growth factor beta type ii receptor (tgf-beta rii) inhibitors as anti-fibrosis agents
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (304 residues)
7l0j
Structure of amh bound to amhr2-ecd
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: amh, mif. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Gene: amhr2, amhr, misr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: B (109 residues)
Bound ligands:   Het Group NAG is 41.38% similar to enzyme product ADP
  Het Group NAG is 41.38% similar to enzyme product ADP
7mrz
Structure of gdf11 bound to fused actriib-ecd and alk4-ecd with anti- actriib fab fragment
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gdf11, bmp11. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Gene: acvr2b, acvr1b, acvrlk4, alk4. Expression_system_taxid: 10029
Chain: C (171 residues)
Bound ligands:   Het Group NAG is 41.38% similar to enzyme product ADP
  Het Group NAG is 41.38% similar to enzyme product ADP
7nns
Crystal structure of the acvr1 (alk2) kinase in complex with the compound momelotinib
Source: Homo sapiens. Organism_taxid: 9606. Gene: acvr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: B (296 residues)
7oly
Structure of activin a in complex with an actriib-alk4 fusion reveal insight into activin receptor interactions
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: inhba. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: cho. Gene: acvr2b. Gene: acvr1b, acvrlk4, alk4.
Chains: C, K (95 residues)
Bound ligands:   Het Group NAG is 41.38% similar to enzyme product ADP
  Het Group NAG is 41.38% similar to enzyme product ADP
7ppa
High resolution structure of bone morphogenetic protein receptor type ii (bmprii) extracellular domain in complex with bmp10
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmp10. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek ebna. Gene: bmpr2, pph1. Expressed in: escherichia coli.
Chains: C, D (105 residues)
7ppb
2.4 angstrom crystal structure of bone morphogenetic protein receptor type ii (bmprii) extracellular domain in complex with bmp10
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmp10. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek ebna. Gene: bmpr2, pph1. Expressed in: escherichia coli.
Chain: B (95 residues)
7ppc
Ternary signalling complex of bmp10 bound to alk1 and bmprii
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmp10. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek ebna. Gene: acvrl1, acvrlk1, alk1. Expressed in: escherichia coli.
Chains: E, F, G, H, I, J, K, L (77 residues)
7u5o
Crystal structure of the bone morphogenetic protein receptor type 2 ligand binding domain in complex with activin-b
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: inhbb. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Gene: bmpr2, pph1. Expression_system_taxid: 10029
Chains: E, F, G (84 residues)
7u5p
Crystal structure of the activin receptor type-2a ligand binding domain in complex with activin-a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr2a, acvr2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Gene: inhba. Expression_system_taxid: 10029
Chains: A, C, E, G (94 residues)
Bound ligands:   Het Group NAG is 41.38% similar to enzyme product ADP
  Het Group NAG is 41.38% similar to enzyme product ADP
7yru
Alk2 antibody complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Rattus norvegicus. Organism_taxid: 10116. Expressed in: homo sapiens.
Chain: A (78 residues)
8c7w
Crystal structure of the acvr1 (alk2) kinase in complex with the compound m4k2304
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (298 residues)
8c7z
Crystal structure of the acvr1 (alk2) kinase in complex with the compound m4k2308
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (295 residues)
8g4k
Complex of tbrii mini protein binder bound to the tbrii ecd
Source: Synthetic construct. Organism_taxid: 32630. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr2.
Chain: B (111 residues)
8pod
Crystal structure of the kinase domain of acvr1 (alk2) in complex with fkbp12 and mu1700
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: fkbp1a, fkbp1, fkbp12. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
Chain: A (321 residues)
8r7g
Crystal structure of the kinase domain of acvr1 (alk2) with m4k2234
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B, C, D (293 residues)
8uwr
Crystal structure of human acvr1 (alk2) kinase in complex with compound 3
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (297 residues)
8ygz
The crystal structure of tgf beta r2 kinase domain from biortus.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (290 residues)
9b9f
Zebrafish betaglycan orphan domain (zfbgo) in complex with tgf-b3 and extracellular domains of tgfbri and tgfbrii
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfb3. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: tgfbr1, alk5, skr4. Gene: tgfbr2. Danio rerio.
Chains: C, D, H, I (77 residues)
9d20
Crystal structure of dlk1 in complex with acvr2b
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr2b. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: dlk1, dlk. Expression_system_taxid: 7111
Chains: E, A (94 residues)
Bound ligands:   Het Group NAG is 41.38% similar to enzyme product ADP
  Het Group NAG is 41.38% similar to enzyme product ADP
9e9g
Heligmosomoides polygyrus tgf-beta mimic 6 domain 3 (tgm6-d3) bound to human tgf-beta type ii receptor extracellular domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Heligmosomoides polygyrus. Organism_taxid: 6339.
Chain: A (110 residues)
9fdy
Betaglycan orphan domain (ratbgo) in complex with tgf-b1 and extracellular domain of tgfbrii
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfb1, tgfb. Expressed in: escherichia coli. Expression_system_taxid: 562. Rattus norvegicus. Norway rat. Organism_taxid: 10116.
Chains: D, E (107 residues)
9fk5
Zebrafish betaglycan orphan domain (zfbgo) in complex with tgf-b3 and extracellular domains of tgfbri and tgfbrii
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfb3. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: tgfbr1, alk5, skr4. Gene: tgfbr2. Danio rerio.
Chains: C, D (77 residues)
9fkp
Zebrafish betaglycan orphan domain (zfbgo) in complex with tgf-b1 and extracellular domain of tgfbrii
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfb1, tgfb. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: tgfbr2. Danio rerio. Zebrafish.
Chains: D, E (107 residues)
9mir
Cryoem structure of alk3-actriib bound to bmp6
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmpr1a. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_taxid: 10029
Chains: C, D, F, A (92 residues)
Bound ligands:   Het Group NAG is 41.38% similar to enzyme product ADP
  Het Group NAG is 41.38% similar to enzyme product ADP
9n4k
Cryoem structure of alk2-actriib bound to bmp6
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr2b. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Gene: bmp6, vgr. Gene: acvr1, acvrlk2. Expression_system_taxid: 10029
Chains: A, F, C, D (93 residues)
Bound ligands:   Het Group NAG is 41.38% similar to enzyme product ADP
  Het Group NAG is 41.38% similar to enzyme product ADP