_EC 2.5.1.60 protein geranylgeranyltransferase type Ii. 26 PDB entries  
EC 2.-.-.- Transferases. [47,727 PDB entries]
EC 2.5.-.- Transferring alkyl or aryl groups, other than methyl groups. [2,655 PDB entries]
EC 2.5.1.- Transferring alkyl or aryl groups, other than methyl groups. [2,655 PDB entries]
EC 2.5.1.60 protein geranylgeranyltransferase type Ii. [26 PDB entries]
1dce

Reaction: geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L- cysteinyl-[protein] + diphosphate.
 


geranylgeranyl diphosphate
 + L-cysteinyl-[protein]
 = S-geranylgeranyl-L- cysteinyl-[protein]
 +
diphosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): GGTaseII. Rab geranylgeranyltransferase. RabGGTase. type Ii protein geranyl-geranyltransferase.
Comments: This enzyme, along with Ec 2.5.1.58 and Ec 2.5.1.59, constitutes the protein prenyltransferase family of enzymes. Attaches geranylgeranyl groups to two C-terminal cysteines in Ras- related GTPases of a single family, the Rab family (Ypt/Sec4 in lower eukaryotes) that terminate in Xxcc, xcxc and ccxx motifs. Reaction is entirely dependent on the Rab substrate being bound to Rab escort protein (REP). Post-translational modification with the geranylgeranyl moiety is essential for Rab GTPases to be able to control the processes of membrane docking and fusion.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 26 PDB entries in enzyme class E.C.2.5.1.60

  PDB code Protein
1dce
Crystal structure of rab geranylgeranyltransferase from rat brain
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Organism_taxid: 10116
Chains: A, B, C, D (567 residues) CATH domains: 1.25.40.120 2.60.40.1130 3.80.10.10
1ltx
Structure of rab escort protein-1 in complex with rab geranylgeranyl transferase and isoprenoid
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21. Synthetic: yes.
Chains: A, B (536 residues) CATH domains: 1.25.40.120 2.60.40.1130 3.80.10.10
Bound ligand:   Het Group FAR is 51.72% similar to enzyme reactant geranylgeranyl diphosphate
3c72
Engineered rabggtase in complex with a peptidomimetic inhibitor
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: rabggta, ggta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rabggtb, ggtb.
Chains: A, B (306 residues) CATH domain: 1.25.40.120
3dss
Crystal structure of rabggtase(delta lrr; delta ig)
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: rabggta, ggta. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: coexpression of engineered alpha-subunit from pgatev and beta-subunit from pet3 0a. Gene: rabggtb, ggtb.
Chains: A, B (313 residues) CATH domain: 1.25.40.120
3dst
Crystal structure of rabggtase(delta lrr; delta ig)in complex with geranylgeranyl pyrophosphate
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: rabggta, ggta. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: coexpression of engineered alpha-subunit from pgatev and beta-subunit from pet3 0a. Gene: rabggtb, ggtb.
Chains: A, B (311 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group GRG corresponds to enzyme reactant geranylgeranyl diphosphate
3dsu
Crystal structure of rabggtase(delta lrr; delta ig)in complex with farnesyl pyrophosphate
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: rabggta, ggta. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: coexpression of engineered alpha-subunit from pgatev and beta-subunit from pet3 0a. Gene: rabggtb, ggtb.
Chains: A, B (306 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP is 82.76% similar to enzyme reactant geranylgeranyl diphosphate
3dsv
Crystal structure of rabggtase(delta lrr; delta ig)in complex with mono-prenylated peptide ser-cys-ser-cys(gg) derivated from rab7
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: rabggta, ggta. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: coexpression of engineered alpha-subunit from pgatev and beta-subunit from pet3 0a. Gene: rabggtb, ggtb.
Chains: A, B (315 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group GER is 51.72% similar to enzyme reactant geranylgeranyl diphosphate
3dsw
Crystal structure of rabggtase(delta lrr; delta ig)in complex with mono-prenylated peptide ser-cys(gg)-ser-cys derivated from rab7
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: rabggta, ggta. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: coexpression of engineered alpha-subunit from pgatev and beta-subunit from pet3 0a. Gene: rabggtb, ggtb.
Chains: A, B (313 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group GER is 41.38% similar to enzyme reactant geranylgeranyl diphosphate
3dsx
Crystal structure of rabggtase(delta lrr; delta ig)in complex with di- prenylated peptide ser-cys(gg)-ser-cys(gg) derivated from rab7
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: rabggta, ggta. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: coexpression of engineered alpha-subunit from pgatev and beta-subunit from pet3 0a. Gene: rabggtb, ggtb.
Chains: A, B (316 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group GER is 68.97% similar to enzyme reactant geranylgeranyl diphosphate
3hxb
Engineered rabggtase in complex with a peptidomimetic inhibitor (compound 6)
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: rabggta, ggta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rabggtb, ggtb.
Chains: A, B (308 residues) CATH domain: 1.25.40.120
3hxc
Engineered rabggtase in complex with a peptidomimetic inhibitor (compound 8)
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (307 residues) CATH domain: 1.25.40.120
3hxd
Engineered rabggtase in complex with a peptidomimetic inhibitor (compound 9)
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (308 residues) CATH domain: 1.25.40.120
3hxe
Engineered rabggtase in complex with a peptidomimetic inhibitor (compound 37)
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (306 residues) CATH domain: 1.25.40.120
3hxf
Engineered rabggtase in complex with a peptidomimetic inhibitor (compound 32)
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (309 residues) CATH domain: 1.25.40.120
3pz1
Crystal structure of rabggtase(delta lrr; delta ig) in complex with bms3
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: rabggta, ggta. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: rabggtb, ggtb.
Chains: A, B (305 residues) CATH domain: 1.25.40.120
3pz2
Crystal structure of rabggtase(delta lrr; delta ig) in complex with bms3 and lipid substrate ggpp
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: rabggta, ggta. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: rabggtb, ggtb.
Chains: A, B (298 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group GRG corresponds to enzyme reactant geranylgeranyl diphosphate
3pz3
Crystal structure of rabggtase(delta lrr; delta ig) in complex with bms-analogue 14
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: rabggta, ggta. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: rabggtb, ggtb.
Chains: A, B (308 residues) CATH domain: 1.25.40.120
4ehm
Rabggtase in complex with covalently bound psoromic acid
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: ggta, rabggta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ggtb, rabggtb.
Chains: A, B (319 residues) CATH domain: 1.25.40.120
4gts
Engineered rabggtase in complex with bms analogue 16
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: rabggta, ggta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rabggtb, ggtb.
Chains: A, B (312 residues) CATH domain: 1.25.40.120
4gtt
Engineered rabggtase in complex with bms analogue 12
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: rabggta, ggta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rabggtb, ggtb.
Chains: A, B (311 residues) CATH domain: 1.25.40.120
4gtv
Engineered rabggtase in complex with bms analogue 13
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: rabggta, ggta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rabggtb, ggtb.
Chains: A, B (307 residues) CATH domain: 1.25.40.120
6j6x
Crystal structure of apo ggtaseiii
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptar1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rabggtb, ggtb. Expression_system_taxid: 562
Chain: B (298 residues)
6j74
Complex of ggtaseiii and full-length ykt6
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptar1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rabggtb, ggtb. Gene: ykt6. Expression_system_taxid: 562
Chain: B (328 residues)
Bound ligand:   Het Group PO4 is 55.56% similar to enzyme product diphosphate
6j7f
Complex of ggtaseiii, farnesyl-ykt6 (c-terminal methylated), and ggpp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptar1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rabggtb, ggtb. Gene: ykt6. Expression_system_taxid: 562
Chain: B (329 residues)
Bound ligands:   Het Group GER is 68.97% similar to enzyme reactant geranylgeranyl diphosphate
  Het Group DPO corresponds to enzyme product diphosphate
6j7x
Complex of ggtaseiii, farnesyl-ykt6, and ggpp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptar1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: rabggtb, ggtb. Gene: ykt6. Expression_system_taxid: 562
Chain: B (327 residues)
Bound ligand:   Het Group GRG corresponds to enzyme reactant geranylgeranyl diphosphate
6o60
Crystal structure of ggtase3-fbxl2-skp1 complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptar1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: rabggtb, ggtb. Gene: fbxl2, fbl2, fbl3. Gene: skp1, emc19, ocp2, skp1a, tceb1l.
Chain: B (320 residues)