_EC 2.5.1.58 protein farnesyltransferase. 83 PDB entries  
EC 2.-.-.- Transferases. [47,727 PDB entries]
EC 2.5.-.- Transferring alkyl or aryl groups, other than methyl groups. [2,655 PDB entries]
EC 2.5.1.- Transferring alkyl or aryl groups, other than methyl groups. [2,655 PDB entries]
EC 2.5.1.58 protein farnesyltransferase. [83 PDB entries]
1d8d

Reaction: L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)- farnesyl-L-cysteinyl-[protein] + diphosphate.
 

L-cysteinyl-[protein]
 +
(2E,6E)-farnesyl diphosphate
 = S-(2E,6E)- farnesyl-L-cysteinyl-[protein]
 +
diphosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Caax farnesyltransferase. FTase.
Comments: This enzyme, along with Ec 2.5.1.59 and Ec 2.5.1.60, constitutes the protein prenyltransferase family of enzymes. Catalyzes the formation of a thioether linkage between the C-1 of an isoprenyl group and a cysteine residue fourth from the C-terminus of the protein. These protein acceptors have the C-terminal sequence CA(1)A(2)X, where the terminal residue, X, is preferably serine, methionine, alanine or glutamine; leucine makes the protein a substrate for Ec 2.5.1.59. The enzymes are relaxed in specificity for A(1), but cannot act if
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 83 PDB entries in enzyme class E.C.2.5.1.58

  PDB code Protein
1d8d
Co-crystal structure of rat protein farnesyltransferase complexed with a k-ras4b peptide substrate and fpp analog at 2.0a resolution
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Organ: brain. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_atcc_number: 63134. Synthetic: yes. Other_details: this synthetic peptide is derived from human k-ras4b,
Chains: A, B (323 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FII is 50.00% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
1d8e
Zinc-depleted ftase complexed with k-ras4b peptide substrate and fpp analog.
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Organ: brain. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_atcc_number: 63134. Synthetic: yes. Other_details: this synthetic peptide is derived from human k-ras4b,
Chains: A, B (323 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FII is 50.00% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
1fpp
Protein farnesyltransferase complex with farnesyl diphosphate
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: fnta, fntb. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five (invitrogen). Other_details: viral expression constructs were provided by m. S. Brown and j. L. Goldstein (southwestern medical center, dallas, tx).
Chains: B, A (400 residues) CATH domain: 1.50.10.20
Bound ligands:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
  Het Group PO4 is 55.56% similar to enzyme product diphosphate
1ft1
Crystal structure of protein farnesyltransferase at 2.25 angstroms resolution
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Organ: brain. Cellular_location: cytoplasm. Gene: cdna. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (315 residues) CATH domain: 1.25.40.120
1ft2
Co-crystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Collection: atcc 63134 for alpha subunit, atcc 63127 for beta subunit. Organ: brain. Cellular_location: cytoplasm. Gene: cdna. Expressed in: spodoptera frugiperda.
Chains: A, B (315 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
1jcq
Crystal structure of human protein farnesyltransferase complexed with farnesyl diphosphate and the peptidomimetic inhibitor l-739,750
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (313 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
1jcr
Crystal structure of rat protein farnesyltransferase complexed with the non-substrate tetrapeptide inhibitor cvfm and farnesyl diphosphate substrate
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_atcc_number: 63134. Synthetic: yes
Chains: A, B (323 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
1jcs
Crystal structure of rat protein farnesyltransferase complexed with the peptide substrate tkcvfm and an analog of farnesyl diphosphate
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_atcc_number: 63134. Synthetic: yes
Chains: A, B (323 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FII is 50.00% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
1kzo
Protein farnesyltransferase complexed with farnesylated k-ras4b peptide product and farnesyl diphosphate substrate bound simultaneously
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_atcc_number: 63134. Synthetic: yes. Other_details: the peptide was chemically synthesized. The sequence of the peptide is naturally found in homo sapiens.
Chains: A, B (323 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
1kzp
Protein farnesyltransferase complexed with a farnesylated k-ras4b peptide product
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_atcc_number: 63134. Synthetic: yes. Other_details: the protein was chemically synthesized. The sequence of the protein is naturally found in homo sapiens.
Chains: A, B (323 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FAR is 62.50% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
1ld7
Co-crystal structure of human farnesyltransferase with farnesyldiphosphate and inhibitor compound 66
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (313 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
1ld8
Co-crystal structure of human farnesyltransferase with farnesyldiphosphate and inhibitor compound 49
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (313 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
1mzc
Co-crystal structure of human farnesyltransferase with farnesyldiphosphate and inhibitor compound 33a
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (313 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
1n4p
Protein geranylgeranyltransferase type-i complexed with geranylgeranyl diphosphate
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: fnta. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: pggt1b. Synthetic: yes. Homo sapiens.
Chains: A, C, E, G, I, K (314 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group GRG is 82.76% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
1n4q
Protein geranylgeranyltransferase type-i complexed with a ggpp analog and a kkksktkcvil peptide
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: fnta. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: pggt1b. Synthetic: yes. Homo sapiens.
Chains: A, C, E, G, I, K (314 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group GER is 51.72% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
1n4r
Protein geranylgeranyltransferase type-i complexed with a geranylgeranylated kkksktkcvil peptide product
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: fnta. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: pggt1b. Synthetic: yes. Homo sapiens.
Chains: A, C, E, G, I, K (314 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group GER is 51.72% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
1n4s
Protein geranylgeranyltransferase type-i complexed with ggpp and a geranylgeranylated kkksktkcvil peptide product
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: fnta. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: pggt1b. Synthetic: yes. Homo sapiens.
Chains: A, C, E, G, I, K (314 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group GRG is 82.76% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
1n94
Aryl tetrahydropyridine inhbitors of farnesyltransferase: glycine, phenylalanine and histidine derivates
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (315 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group HFP is 57.14% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
1n95
Aryl tetrahydrophyridine inhbitors of farnesyltranferase: glycine, phenylalanine and histidine derivatives
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (312 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group HFP is 57.14% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
1n9a
Farnesyltransferase complex with tetrahydropyridine inhibitors
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (312 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group HFP is 57.14% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
1ni1
Imidazole and cyanophenyl farnesyl transferase inhibitors
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: fnta. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: fntb.
Chains: A, B (312 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group HFP is 57.14% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
1nl4
Crystal structure of rat farnesyl transferase in complex with a potent biphenyl inhibitor
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: fnta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fntb. Expression_system_taxid: 562
Chains: A, B (312 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group HFP is 57.14% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
1o1r
Structure of fpt bound to ggpp
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (315 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group GRG is 82.76% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
1o1s
Structure of fpt bound to isoprenoid analog 3b
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (315 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group 1NH is 47.50% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
1o1t
Structure of fpt bound to the cvim-fpp product
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: fnta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fntb.
Chains: A, B (315 residues) CATH domain: 1.25.40.120
1o5m
Structure of fpt bound to the inhibitor sch66336
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: fnta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fntb. Expression_system_taxid: 562
Chains: A, B (315 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
1qbq
Structure of rat farnesyl protein transferase complexed with a cvim peptide and alpha-hydroxyfarnesylphosphonic acid.
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Synthetic: yes. Other_details: purchased from anaspec inc.
Chains: A, B (312 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group HFP is 57.14% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
1s63
Human protein farnesyltransferase complexed with l-778,123 and fpp
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: brain. Gene: fnta. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_atcc_number: 63134. Gene: fntb.
Chains: A, B (315 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
1s64
Rat protein geranylgeranyltransferase type-i complexed with l-778,123 and a sulfate anion
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: fnta. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: pggt1b. Expression_system_taxid: 7108
Chains: A, C, E, G, I, K (314 residues) CATH domain: 1.25.40.120
1sa4
Human protein farnesyltransferase complexed with fpp and r115777
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fnta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fntb. Expression_system_taxid: 562
Chains: A, B (315 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
1sa5
Rat protein farnesyltransferase complexed with fpp and bms-214662
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: fnta. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: fntb.
Chains: A, B (323 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
1tn6
Protein farnesyltransferase complexed with a rap2a peptide substrate and a fpp analog at 1.8a resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fnta. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: fntb. Synthetic: yes. Other_details: peptide was chemically synthesized. The sequence of
Chains: A, B (315 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FII is 50.00% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
1tn7
Protein farnesyltransferase complexed with a tc21 peptide substrate and a fpp analog at 2.3a resolution
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: fnta. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: fntb. Synthetic: yes. Other_details: the fusion protein was chemically synthesized
Chains: A, B (323 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FII is 50.00% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
1tn8
Protein farnesyltransferase complexed with a h-ras peptide substrate and a fpp analog at 2.25a resolution
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: fnta. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: fntb. Synthetic: yes. Other_details: peptide was chemically synthesized. The sequence of
Chains: A, B (323 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FII is 50.00% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
1tnb
Rat protein geranylgeranyltransferase type-i complexed with a ggpp analog and a substrate kksktkcvif peptide derived from tc21
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: fnta. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: pggt1b. Synthetic: yes. Other_details: the fusion protein was chemically synthesized.The
Chains: A, C, E, G, I, K (314 residues) CATH domain: 1.25.40.120
1tno
Rat protein geranylgeranyltransferase type-i complexed with a ggpp analog and a kkksktkcvim peptide derived from k-ras4b
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: fnta. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: pggt1b. Synthetic: yes. Other_details: the substrate peptide was chemically synthesized. The
Chains: A, C, E, G, I, K (314 residues) CATH domain: 1.25.40.120
1tnu
Rat protein geranylgeranyltransferase type-i complexed with a ggpp analog and a gcincckvl peptide derived from rhob
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: fnta. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: pggt1b. Synthetic: yes. Other_details: the rhob substrate peptide was chemically
Chains: A, C, E, G, I, K (314 residues) CATH domain: 1.25.40.120
1tny
Rat protein geranylgeranyltransferase type-i complexed with a ggpp analog and a frekkffcail peptide derived from the heterotrimeric g protein gamma-2 subunit
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: fnta. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: pggt1b. Synthetic: yes. Other_details: the substrate peptide was chemically synthesized. The
Chains: A, C, E, G, I, K (314 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group PHE is 41.67% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
1tnz
Rat protein geranylgeranyltransferase type-i complexed with a ggpp analog and a rrcvll peptide derived from cdc42 splice isoform-2
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: fnta. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: pggt1b. Synthetic: yes. Other_details: the substrate peptide was chemically synthesized. The
Chains: A, C, E, G, I, K (314 residues) CATH domain: 1.25.40.120
1x81
Farnesyl transferase structure of jansen compound
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Organism_taxid: 10116
Chains: A, B (315 residues) CATH domain: 1.25.40.120
2bed
Structure of fpt bound to inhibitor sch207736
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: fnta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fntb. Expression_system_taxid: 562
Chains: A, B (313 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
2f0y
Crystal structure of human protein farnesyltransferase complexed with farnesyl diphosphate and hydantoin derivative
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (314 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
2h6f
Protein farnesyltransferase complexed with a farnesylated ddptasacvls peptide product at 1.5a resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fnta. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: fntb. Synthetic: yes. Other_details: peptide was chemically synthesized
Chains: A, B (315 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FAR is 62.50% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
2h6g
W102t protein farnesyltransferase mutant complexed with a geranylgeranylated ddptasacvls peptide product at 1.85a resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: human ftase alpha subunit. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: human ftase beta subunit. Synthetic: yes. Other_details: chemically synthesized
Chains: A, B (315 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group GER is 51.72% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
2h6h
Y365f protein farnesyltransferase mutant complexed with a farnesylated ddptasacvls peptide product at 1.8a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: human ftase alpha subunit. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: human ftase beta subunit. Synthetic: yes. Other_details: chemically synthesized
Chains: A, B (315 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FAR is 62.50% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
2h6i
W102t/y365f protein farnesyltransferase double mutant complexed with a geranylgeranylated ddptasacvls peptide product at 3.0a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: human ftase alpha subunit. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: human ftase beta subunit. Synthetic: yes. Other_details: chemically synthesized
Chains: A, B (315 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group GER is 51.72% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
2iej
Human protein farnesyltransferase complexed with inhibitor compound stn-48 and fpp analog at 1.8a resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fnta. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: fntb.
Chains: A, B (315 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FII is 50.00% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
2r2l
Structure of farnesyl protein transferase bound to pb-93
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: fnta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fntb. Expression_system_taxid: 562
Chains: A, B (315 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
2zir
Crystal structure of rat protein farnesyltransferase complexed with a benzofuran inhibitor and fpp
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: fnta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fntb.
Chains: A, B (314 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
2zis
Crystal structure of rat protein farnesyltransferase complexed with a bezoruran inhibitor and fpp
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: fnta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fntb.
Chains: A, B (314 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
3dpy
Protein farnesyltransferase complexed with fpp and caged tkcvim substrate
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: fnta. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: fntb. Synthetic: yes. Other_details: synthesized peptide
Chains: A, B (323 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
3dra
Candida albicans protein geranylgeranyltransferase-i complexed with ggpp
Source: Candida albicans. Yeast. Organism_taxid: 5476. Gene: ram2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: cdc43. Expression_system_taxid: 562
Chain: A (302 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group GRG is 82.76% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
3e30
Protein farnesyltransferase complexed with fpp and ethylene diamine inhibitor 4
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: fnta. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: fntb. Expression_system_taxid: 7108
Chains: A, B (323 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
3e32
Protein farnesyltransferase complexed with fpp and ethylenediamine scaffold inhibitor 2
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: fnta. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: fntb. Expression_system_taxid: 7108
Chains: A, B (323 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
3e33
Protein farnesyltransferase complexed with fpp and ethylenediamine scaffold inhibitor 7
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: fnta. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: fntb. Expression_system_taxid: 7108
Chains: A, B (323 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
3e34
Protein farnesyltransferase complexed with fpp and ethylenediamine- scaffold inhibitor 10
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: fnta. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: fntb. Expression_system_taxid: 7108
Chains: A, B (323 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
3e37
Protein farnesyltransferase complexed with bisubstrate ethylenediamine scaffold inhibitor 5
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fnta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fntb. Expression_system_taxid: 562
Chains: A, B (315 residues) CATH domain: 1.25.40.120
3eu5
Crystal structure of ftase(alpha-subunit; beta-subunit delta c10) in complex with biotingpp
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (315 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group GBO is 47.50% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
3euv
Crystal structure of ftase(alpha-subunit; beta-subunit delta c10, w102t, y154t) in complex with biotingpp
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (315 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group GBO is 47.50% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
3ksl
Structure of fpt bound to datfp-dh-gpp
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: fnta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fntb.
Chains: A, B (315 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group SZH is 55.88% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
3ksq
Discovery of c-imidazole azaheptapyridine fpt inhibitors
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: fnta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fntb. Expression_system_taxid: 562
Chains: A, B (315 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
3pz4
Crystal structure of ftase(alpha-subunit; beta-subunit delta c10) in complex with bms3 and lipid substrate fpp
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: fnta, ggta, rabggta. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: fntb, ggtb, rabggtb.
Chains: A, B (315 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
4gtm
Ftase in complex with bms analogue 11
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: fnta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fntb.
Chains: A, B (318 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
4gto
Ftase in complex with bms analogue 14
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: fnta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fntb.
Chains: A, B (317 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP is 64.29% similar to enzyme product diphosphate
4gtp
Ftase in complex with bms analogue 16
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: fnta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fntb.
Chains: A, B (315 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
4gtq
Ftase in complex with bms analogue 12
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: fnta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fntb.
Chains: A, B (315 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
4gtr
Ftase in complex with bms analogue 13
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: fnta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fntb.
Chains: A, B (315 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
4l9p
Crystal structure of aspergillus fumigatus protein farnesyltransferase complexed with the fii analog, fpt-ii, and the kcvvm peptide
Source: Aspergillus fumigatus. Organism_taxid: 330879. Strain: af293. Gene: afua_4g07800. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: afua_4g10330. Synthetic: yes
Chains: A, B (335 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FII is 50.00% similar to enzyme reactant (2E,6E)-farnesyl diphosphate
4lnb
Aspergillus fumigatus protein farnesyltransferase ternary complex with farnesyldiphosphate and ethylenediamine scaffold inhibitor 5
Source: Aspergillus fumigatus. Organism_taxid: 330879. Strain: atcc mya-4609 / af293 / cbs 101355 / fgsc a1100. Gene: afua_4g07800, ncbi locus xm_746952 ram2 gene. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: afua_4g10330, ncbi locus xm_746700 ram1 gene.
Chains: A, B (339 residues) CATH domain: 1.25.40.120
4lng
Aspergillus fumigatus protein farnesyltransferase complex with farnesyldiphosphate and tipifarnib
Source: Aspergillus fumigatus. Organism_taxid: 330879. Strain: atcc mya-4609 / af293 / cbs 101355 / fgsc a1100. Gene: afua_4g07800, ncbi locus xm_746952 ram2 gene. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: afua_4g10330, ncbi locus xm_746700 ram1 gene.
Chains: A, B (335 residues) CATH domain: 1.25.40.120
4mbg
Crystal structure of aspergillus fumigatus protein farnesyltransferase binary complex with farnesyldiphosphate
Source: Aspergillus fumigatus. Organism_taxid: 330879. Strain: atcc mya-4609 / af293 / cbs 101355 / fgsc a1100. Gene: afua_4g07800. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: afua_4g10330.
Chains: A, B (335 residues) CATH domain: 1.25.40.120
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
4ydo
Crystal structure of candida albicans protein farnesyltransferase in apo form
Source: Candida albicans. Yeast. Organism_taxid: 5476. Gene: ram2. Expressed in: escherichia coli. Expression_system_taxid: 562. Organism_taxid: 237561. Strain: sc5314 / atcc mya-2876. Gene: ram1, cao19.12513.
Chain: A (303 residues) CATH domain: 1.25.40.120
7rn5
Discovery of an anion-dependent farnesyltransferase inhibitor from a phenotypic screen
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: fnta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fntb. Expression_system_taxid: 562
Chains: A, B (313 residues)
Bound ligand:   Het Group PPV corresponds to enzyme product diphosphate
7rni
Discovery of an anion-dependent farnesyltransferase inhibitor from a phenotypic screen
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: fnta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fntb. Expression_system_taxid: 562
Chains: A, B (315 residues)
Bound ligand:   Het Group DMA is 64.29% similar to enzyme product diphosphate
7t08
Cryptococcus neoformans protein farnesyltransferase in complex with fpp and inhibitor 2q
Source: Cryptococcus neoformans var. Grubii serotype a (strain h99 / atcc 208821 / cbs 10515 / fgsc 9487). Organism_taxid: 235443. Strain: h99 / atcc 208821 / cbs 10515 / fgsc 9487. Gene: cnag_02229. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: cnag_05740. Expression_system_taxid: 562
Chains: A, B (316 residues)
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
7t09
Cryptococcus neoformans protein farnesyltransferase in complex with fpp and inhibitor 2d
Source: Cryptococcus neoformans var. Grubii h99. Organism_taxid: 235443. Strain: h99 / atcc 208821 / cbs 10515 / fgsc 9487. Gene: cnag_02229. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: cnag_05740. Expression_system_taxid: 562
Chains: A, B (318 residues)
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
7t0a
Cryptococcus neoformans protein farnesyltransferase co-crystallized with fpp and inhibitor 2f
Source: Cryptococcus neoformans var. Grubii h99. Organism_taxid: 235443. Strain: h99 / atcc 208821 / cbs 10515 / fgsc 9487. Gene: cnag_02229. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: cnag_05740. Expression_system_taxid: 562
Chains: A, B (318 residues)
7t0b
Cryptococcus neoformans protein farnesyltransferase in complex with fpp and inhibitor 2g
Source: Cryptococcus neoformans var. Grubii h99. Organism_taxid: 235443. Strain: h99 / atcc 208821 / cbs 10515 / fgsc 9487. Gene: cnag_02229. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: cnag_05740. Expression_system_taxid: 562
Chains: A, B (318 residues)
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
7t0c
Cryptococcus neoformans protein farnesyltransferase in complex with fpp and inhibitor 2e
Source: Cryptococcus neoformans var. Grubii h99. Organism_taxid: 235443. Strain: h99 / atcc 208821 / cbs 10515 / fgsc 9487. Gene: cnag_02229. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: cnag_05740. Expression_system_taxid: 562
Chains: A, B (316 residues)
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
7t0d
Cryptococcus neoformans protein farnesyltransferase in complex with fpp and inhibitor 2k
Source: Cryptococcus neoformans var. Grubii h99. Organism_taxid: 235443. Strain: h99 / atcc 208821 / cbs 10515 / fgsc 9487. Gene: cnag_02229. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: cnag_05740. Expression_system_taxid: 562
Chains: A, B (318 residues)
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
7t0e
Cryptococcus neoformans protein farnesyltransferase in complex with fpp and inhibitor 2b
Source: Cryptococcus neoformans var. Grubii h99. Organism_taxid: 235443. Strain: h99 / atcc 208821 / cbs 10515 / fgsc 9487. Gene: cnag_02229. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: cnag_05740. Expression_system_taxid: 562
Chains: A, B (318 residues)
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
8e9e
Rat protein farnesyltransferase in complex with fpp and inhibitor 2f
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: fnta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fntb. Expression_system_taxid: 562
Chains: A, B (323 residues)
Bound ligand:   Het Group FPP corresponds to enzyme reactant (2E,6E)-farnesyl diphosphate
8t70
Cryptococcus neoformans protein farnesyltransferase in complex with fptii and tkcmiim peptide
Source: Cryptococcus neoformans. Organism_taxid: 5207. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
Chains: A, B (318 residues)
Bound ligand:   Het Group FII is 50.00% similar to enzyme reactant (2E,6E)-farnesyl diphosphate