_EC 2.3.1.87 Aralkylamine N-acetyltransferase. 9 PDB entries  
EC 2.-.-.- Transferases. [19,327 PDB entries]
EC 2.3.-.- Acyltransferases. [1,339 PDB entries]
EC 2.3.1.- Transferring groups other than amino-acyl groups. [1,111 PDB entries]
EC 2.3.1.87 Aralkylamine N-acetyltransferase. [9 PDB entries]    
1b6b

Reaction: Acetyl-CoA + a 2-arylethylamine = CoA + an N-acetyl-2-arylethylamine.
 


Acetyl-CoA
+
2-arylethylamine
=
CoA
+
N-acetyl-2-arylethylamine
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Aanat. Arylalkylamine N-acetyltransferase. Melatonin rhythm enzyme. Serotonin acetylase. Serotonin acetyltransferase. Serotonin N-acetyltransferase.
Comments: Narrow specificity toward 2-arylethylamines, including serotonin (5-hydroxytryptamine), tryptamine, 5-methoxytryptamine and phenylethylamine. This is the penultimate enzyme in the production of melatonin (5-methoxy-N-acetyltryptamine) and controls its synthesis (cf. Ec 2.1.1.4). Differs from Ec 2.3.1.5.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 9 PDB entries in enzyme class E.C.2.3.1.87

  PDB code Protein
1b6b
Melatonin biosynthesis: the structure of serotonin n- acetyltransferase at 2.5 a resolution suggests a catalytic mechanism
Source: Ovis aries. Sheep. Organism_taxid: 9940. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (168 residues) CATH domain: 3.40.630.30
1cjw
Serotonin n-acetyltransferase complexed with a bisubstrate a
Source: Ovis aries. Sheep. Organism_taxid: 9940. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (166 residues) CATH domain: 3.40.630.30
Bound ligand:   Het Group COT is 78.12% similar to enzyme reactant acetyl-CoA
1ib1
Crystal structure of the 14-3-3 zeta:serotonin n- acetyltransferase complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ywhaz. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Ovis aries. Sheep. Organism_taxid: 9940.
Chains: E, F, G, H (179 residues) CATH domain: 3.40.630.30
Bound ligand:   Het Group COT is 78.00% similar to enzyme reactant acetyl-CoA
1kuv
X-ray crystallographic studies of serotonin n-acetyltransfer catalysis and inhibition
Source: Ovis aries. Sheep. Organism_taxid: 9940. Gene: u29663. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (166 residues) CATH domain: 3.40.630.30
Bound ligand:   Het Group CA5 is 76.92% similar to enzyme reactant acetyl-CoA
1kux
X-ray crystallographic studies of serotonin n- acetyltransferase catalysis and inhibition
Source: Ovis aries. Sheep. Organism_taxid: 9940. Gene: u29663. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (166 residues) CATH domain: 3.40.630.30
Bound ligand:   Het Group CA3 is 74.00% similar to enzyme reactant acetyl-CoA
1kuy
X-ray crystallographic studies of serotonin n- acetyltransferase catalysis and inhibition
Source: Ovis aries. Sheep. Organism_taxid: 9940. Gene: u29663. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (166 residues) CATH domain: 3.40.630.30
Bound ligand:   Het Group COT is 78.00% similar to enzyme reactant acetyl-CoA
1l0c
Investigation of the roles of catalytic residues in serotoni acetyltransferase
Source: Ovis aries. Sheep. Organism_taxid: 9940. Gene: aanat. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (166 residues) CATH domain: 3.40.630.30
Bound ligand:   Het Group COT is 78.12% similar to enzyme reactant acetyl-CoA
3te4
Crystal structure of dopamine n acetyltransferase in complex acetyl-coa from drosophila melanogaster
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: cg3318, dat, dmel_cg3318. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (210 residues) CATH domain: Unassigned
Bound ligand:   Het Group ACO corresponds to enzyme reactant acetyl-CoA
3v8i
Crystal structure of a drosophila melanogaster dopamine n- acetyltransferase
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: cg3318, dat, dmel_cg3318. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (210 residues) CATH domain: Unassigned