EC 2.1.1.148 - thymidylate synthase (FAD).

_EC 2.1.1.148 thymidylate synthase (FAD).

49 PDB entries

EC 2.-.-.- Transferases. [47,771 PDB entries]

EC 2.1.-.- Transferring one-carbon groups. [5,181 PDB entries]

EC 2.1.1.- Methyltransferases. [4,592 PDB entries]

EC 2.1.1.148 thymidylate synthase (FAD). [49 PDB entries]

1kq4

Reaction: dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + Nadph + H(+) = dTMP + (6S)-5,6,7,8-tetrahydrofolate + NADP(+).

dUMP
+ (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate
+
NADPH
+ H(+)
=
dTMP
+ (6S)-5,6,7,8-tetrahydrofolate
+
NADP(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Fdts. flavin dependent thymidylate synthase.

Comments: Contains Fad. All thymidylate synthases catalyze a reductive methylation involving the transfer of the methylene group of 5,10-methylenetetrahydrofolate to the C5-position of dUMP and a two electron reduction of the methylene group to a methyl group. Unlike the classical thymidylate synthase, ThyA (EC 2.1.1.45), which uses folate as both a 1-carbon donor and a source of reducing equivalents, this enzyme uses a flavin cofactor as a source of reducing equivalents, which are derived from Nadph.

Links: [IntEnz] [ExPASy] [KEGG]

There are 49 PDB entries in enzyme class E.C.2.1.1.148

PDB code Protein

1kq4

Crystal structure of a thy1-complementing protein (tm0449) from thermotoga maritima at 2.25 a resolution

Source: Thermotoga maritima. Organism_taxid: 2336. Gene: tm0449. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D (203 residues) CATH domain: 3.30.1360.170

Bound ligand: Het Group FAD is 71.19% similar to enzyme reactant NADPH

1o24

Crystal structure of thymidylate synthase complementing protein (tm0449) from thermotoga maritima at 2.0 a resolution

Source: Thermotoga maritima. Organism_taxid: 2336. Gene: tm0449. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D (208 residues) CATH domain: 3.30.1360.170

1o25

Crystal structure of thymidylate synthase complementing protein (tm0449) from thermotoga maritima with dump at 2.4 a resolution

Source: Thermotoga maritima. Organism_taxid: 2336. Gene: tm0449. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D (214 residues) CATH domain: 3.30.1360.170

Bound ligand: Het Group UMP corresponds to enzyme reactant dUMP

1o26

Crystal structure of thymidylate synthase complementing protein (tm0449) from thermotoga maritima with fad and dump at 1.6 a resolution

Source: Thermotoga maritima. Organism_taxid: 2336. Gene: tm0449. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D (219 residues) CATH domain: 3.30.1360.170

Bound ligands: Het Group UMP corresponds to enzyme reactant dUMP

Het Group FAD is 71.19% similar to enzyme reactant NADPH

1o27

Crystal structure of thymidylate synthase complementing protein (tm0449) from thermotoga maritima with fad and brdump at 2.3 a resolution

Source: Thermotoga maritima. Organism_taxid: 2336. Gene: tm0449. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D (216 residues) CATH domain: 3.30.1360.170

Bound ligands: Het Group BRU is 95.24% similar to enzyme reactant dUMP

Het Group FAD is 71.19% similar to enzyme reactant NADPH

1o28

Crystal structure of thymidylate synthase complementing protein (tm0449) from thermotoga maritima with fdump at 2.1 a resolution

Source: Thermotoga maritima. Organism_taxid: 2336. Gene: tm0449. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D (218 residues) CATH domain: 3.30.1360.170

Bound ligand: Het Group UFP is 95.24% similar to enzyme reactant dUMP

1o29

Crystal structure of thymidylate synthase complementing protein (tm0449) from thermotoga maritima with fad and fdump at 2.0 a resolution

Source: Thermotoga maritima. Organism_taxid: 2336. Gene: tm0449. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D (216 residues) CATH domain: 3.30.1360.170

Bound ligands: Het Group UFP is 95.24% similar to enzyme reactant dUMP

Het Group FAD is 71.19% similar to enzyme reactant NADPH

1o2a

Crystal structure of thymidylate synthase complementing protein (tm0449) from thermotoga maritima with fad at 1.8 a resolution

Source: Thermotoga maritima. Organism_taxid: 2336. Gene: tm0449. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D (211 residues) CATH domain: 3.30.1360.170

Bound ligand: Het Group FAD is 71.19% similar to enzyme reactant NADPH

1o2b

Crystal structure of thymidylate synthase complementing protein (tm0449) from thermotoga maritima with fad and po4 at 2.45 a resolution

Source: Thermotoga maritima. Organism_taxid: 2336. Gene: tm0449. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D (213 residues) CATH domain: 3.30.1360.170

Bound ligand: Het Group FAD is 71.19% similar to enzyme reactant NADPH

2af6

Crystal structure of mycobacterium tuberculosis flavin dependent thymidylate synthase (mtb thyx) in the presence of co-factor fad and substrate analog 5-bromo-2'-deoxyuridine-5'-monophosphate (brdump)

Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: thyx. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D, E, F, G, H (245 residues) CATH domains: 3.30.70.3180 6.10.140.450 6.10.140.440

Bound ligands: Het Group BRU is 95.24% similar to enzyme reactant dUMP

Het Group FAD is 71.19% similar to enzyme reactant NADPH

2cfa

Structure of viral flavin-dependant thymidylate synthase thyx

Source: Paramecium bursaria chlorella virus 1. Organism_taxid: 10506. Expressed in: escherichia coli. Expression_system_taxid: 668369. Expression_system_variant: delta thya.

Chains: A, B (180 residues) CATH domains: 3.30.1360.170 1.20.5.3070

Bound ligand: Het Group FAD is 71.19% similar to enzyme reactant NADPH

2gq2

Mycobacterium tuberculosis thyx-NADP complex

Source: Mycobacterium tuberculosis h37rv. Organism_taxid: 83332. Strain: h37rv. Gene: thyx, rv2754c. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D (242 residues) CATH domains: 3.30.70.3180 6.10.140.450 6.10.140.440

Bound ligand: Het Group NAP corresponds to enzyme reactant NADPH

3ah5

Crystal structure of flavin dependent thymidylate synthase thyx from helicobacter pylori complexed with fad and dump

Source: Helicobacter pylori. Campylobacter pylori. Organism_taxid: 85962. Strain: 26695. Gene: hp_1533, thyx. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D, E, F (215 residues) CATH domain: 3.30.1360.170

Bound ligands: Het Group UMP corresponds to enzyme reactant dUMP

Het Group FAD is 71.19% similar to enzyme reactant NADPH

3fnn

Biochemical and structural analysis of an atypical thyx: corynebacterium glutamicum nchu 87078 depends on thya for thymidine biosynthesis

Source: Corynebacterium glutamicum. Brevibacterium flavum. Organism_taxid: 1718. Strain: 87078. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (227 residues) CATH domains: 3.30.70.3180 6.10.140.450 6.10.140.440

Bound ligand: Het Group FAD is 71.19% similar to enzyme reactant NADPH

3g4a

Crystal structure of flavine dependant thymidylate synthase s88a mutant from thermotoga maritima at 1.95 angstrom resolution

Source: Thermotoga maritima msb8. Organism_taxid: 243274. Strain: msb8 / dsm 3109 / jcm 10099. Atcc: 43589. Gene: thy1, thyx, tm_0449. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D (218 residues) CATH domain: 3.30.1360.170

Bound ligands: Het Group UMP corresponds to enzyme reactant dUMP

Het Group FAD is 71.19% similar to enzyme reactant NADPH

3g4c

Flavine dependant thymidylate syntahse s88c mutant

Source: Thermotoga maritima. Organism_taxid: 2336. Gene: thy1, thyx, tm_0449. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D (209 residues) CATH domain: 3.30.1360.170

Bound ligands: Het Group UMP corresponds to enzyme reactant dUMP

Het Group FAD is 71.19% similar to enzyme reactant NADPH

3ge9

A structurally atypical thyx from corynebacterium glutamicum nchu 87078 is not required for thymidylate biosynthesis

Source: Corynebacterium glutamicum. Organism_taxid: 1718. Strain: 87078. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (216 residues) CATH domains: 3.30.70.3180 6.10.140.450 6.10.140.440

3gwc

Crystal structure of mycobacterium tuberculosis thymidylate synthase x bound to fdump and fad

Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: thyx, rv2754c, mt2824, mtv002.19c. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D, E, F, G, H (246 residues) CATH domains: 3.30.70.3180 6.10.140.450 6.10.140.440

Bound ligands: Het Group UFP is 95.24% similar to enzyme reactant dUMP

Het Group FAD is 71.19% similar to enzyme reactant NADPH

3hzg

Crystal structure of mycobacterium tuberculosis thymidylate synthase x bound with fad

Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: thyx, rv2754c, mt2824, mtv002.19c. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D (245 residues) CATH domains: 3.30.70.3180 6.10.140.450 6.10.140.440

Bound ligand: Het Group FAD is 71.19% similar to enzyme reactant NADPH

3n0b

Tm0449 mutant crystals grown in loops/micromounts

Source: Thermotoga maritima. Organism_taxid: 2336. Gene: thy1, thyx, tm0449, tm_0449. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D (216 residues) CATH domain: 3.30.1360.170

Bound ligands: Het Group UMP corresponds to enzyme reactant dUMP

Het Group FAD is 71.19% similar to enzyme reactant NADPH

3n0c

Tm0449 mutant crystal grown by hanging drop method

Source: Thermotoga maritima. Organism_taxid: 2336. Gene: thy1, thyx, tm0449, tm_0449. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D (216 residues) CATH domain: 3.30.1360.170

Bound ligands: Het Group UMP corresponds to enzyme reactant dUMP

Het Group FAD is 71.19% similar to enzyme reactant NADPH

3n3y

Crystal structure of thymidylate synthase x (thyx) from helicobacter pylori with fad and dump at 2.31a resolution

Source: Helicobacter pylori. Organism_taxid: 102617. Strain: ss1. Gene: thyx. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chains: A, B, C, D (209 residues) CATH domain: 3.30.1360.170

Bound ligands: Het Group UMP corresponds to enzyme reactant dUMP

Het Group FAD is 71.19% similar to enzyme reactant NADPH

4fzb

Structure of thymidylate synthase thyx complexed to a new inhibitor

Source: Paramecium bursaria chlorella virus 1. Pbcv-1. Organism_taxid: 10506. Strain: paramecium bursaria chlorella virus (pbcv-1). Gene: a674r, thyx. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P (191 residues) CATH domains: 3.30.1360.170 1.20.5.3070

Bound ligand: Het Group FAD is 71.19% similar to enzyme reactant NADPH

4gt9

T. Maritima fdts with fad, dump and folate.

Source: Thermotoga maritima. Organism_taxid: 243274. Strain: atcc 43589 / msb8 / dsm 3109 / jcm 10099. Gene: thyx, thy1, tm_0449. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (214 residues) CATH domain: 3.30.1360.170

Bound ligands: Het Group UMP corresponds to enzyme reactant dUMP

Het Group FAD is 71.19% similar to enzyme reactant NADPH

4gta

T. Maritima fdts with fad, dump, and folinic acid

Source: Thermotoga maritima. Organism_taxid: 243274. Strain: atcc 43589 / msb8 / dsm 3109 / jcm 10099. Gene: thyx, thy1, tm_0449. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (215 residues) CATH domain: 3.30.1360.170

Bound ligands: Het Group UMP corresponds to enzyme reactant dUMP

Het Group FAD is 71.19% similar to enzyme reactant NADPH

4gtb

T. Maritima fdts with fad, dump, and raltitrexed.

Source: Thermotoga maritima. Organism_taxid: 243274. Strain: atcc 43589 / msb8 / dsm 3109 / jcm 10099. Gene: thyx, thy1, tm_0449. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (211 residues) CATH domain: 3.30.1360.170

Bound ligands: Het Group UMP corresponds to enzyme reactant dUMP

Het Group FAD is 71.19% similar to enzyme reactant NADPH

4gtc

T. Maritima fdts (e144r mutant) plus fad

Source: Thermotoga maritima. Organism_taxid: 243274. Strain: atcc 43589 / msb8 / dsm 3109 / jcm 10099. Gene: thyx, thy1, tm_0449. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D (218 residues) CATH domain: 3.30.1360.170

Bound ligand: Het Group FAD is 72.92% similar to enzyme reactant NADPH

4gtd

T. Maritima fdts (e144r mutant) with fad and dump

Source: Thermotoga maritima. Organism_taxid: 243274. Strain: atcc 43589 / msb8 / dsm 3109 / jcm 10099. Gene: thyx, thy1, tm_0449. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D (210 residues) CATH domain: 3.30.1360.170

Bound ligands: Het Group UMP corresponds to enzyme reactant dUMP

Het Group FAD is 71.19% similar to enzyme reactant NADPH

4gte

T. Maritima fdts (e144r mutant) with fad and folate

Source: Thermotoga maritima. Organism_taxid: 243274. Strain: atcc 43589 / msb8 / dsm 3109 / jcm 10099. Gene: thyx, thy1, tm_0449. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D (215 residues) CATH domain: 3.30.1360.170

Bound ligand: Het Group FAD is 72.92% similar to enzyme reactant NADPH

4gtf

T. Maritima fdts (h53a mutant) with fad, dump and folate

Source: Thermotoga maritima. Organism_taxid: 243274. Strain: atcc 43589 / msb8 / dsm 3109 / jcm 10099. Gene: thyx, thy1, tm_0449. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (213 residues) CATH domain: 3.30.1360.170

Bound ligands: Het Group UMP corresponds to enzyme reactant dUMP

Het Group FAD is 71.19% similar to enzyme reactant NADPH

4gtl

T. Maritima fdts (r174k mutant) with fad

Source: Thermotoga maritima. Organism_taxid: 243274. Strain: atcc 43589 / msb8 / dsm 3109 / jcm 10099. Gene: thyx, thy1, tm_0449. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D (216 residues) CATH domain: 3.30.1360.170

Bound ligand: Het Group FAD is 71.19% similar to enzyme reactant NADPH

4kar

Crystal structure of fdts (tm0449) mutant (h53d) with fad

Source: Thermotoga maritima msb8. Organism_taxid: 243274. Strain: atcc 43589 / msb8 / dsm 3109 / jcm 10099. Gene: thy1, thyx, tm0449, tm_0449. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D (214 residues) CATH domain: 3.30.1360.170

Bound ligand: Het Group FAD is 72.92% similar to enzyme reactant NADPH

4kas

Crystal structure of fdts from t. Maritima mutant (h53d) with fad and dump

Source: Thermotoga maritima. Organism_taxid: 243274. Strain: atcc 43589 / msb8 / dsm 3109 / jcm 10099. Gene: thy1, thyx, tm0449, tm_0449. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D (213 residues) CATH domain: 3.30.1360.170

Bound ligands: Het Group DU corresponds to enzyme reactant dUMP

Het Group FAD is 71.19% similar to enzyme reactant NADPH

4kat

Crystal structure of fdts from t. Maritima mutant (r174k) with fad and dump

Source: Thermotoga maritima msb8. Organism_taxid: 243274. Strain: atcc 43589 / msb8 / dsm 3109 / jcm 10099. Gene: thy1, thyx, tm0449, tm_0449. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D (218 residues) CATH domain: 3.30.1360.170

Bound ligands: Het Group DU corresponds to enzyme reactant dUMP

Het Group FDA is 71.19% similar to enzyme reactant NADPH

4p5a

Crystal structure of a ump/dump methylase polb from streptomyces cacaoi bound with 5-br ump

Source: Streptomyces cacaoi subsp. Asoensis. Organism_taxid: 249586. Gene: polb, thyx. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D (226 residues) CATH domain: 3.30.1360.170

Bound ligands: Het Group 5BU is 90.91% similar to enzyme reactant dUMP

Het Group FAD is 71.19% similar to enzyme reactant NADPH

4p5b

Crystal structure of a ump/dump methylase polb from streptomyces cacaoi bound with 5-br dump

Source: Streptomyces cacaoi subsp. Asoensis. Organism_taxid: 249586. Gene: polb, thyx. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, B, C, D (229 residues) CATH domain: 3.30.1360.170

Bound ligands: Het Group BRU is 95.24% similar to enzyme reactant dUMP

Het Group FAD is 71.19% similar to enzyme reactant NADPH

5chp

T. Maritima thyx in complex with tyc5-03

Source: Thermotoga maritima. Organism_taxid: 2336. Gene: thyx, thy1, tm_0449. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (217 residues) CATH domain: 3.30.1360.170

Bound ligand: Het Group FAD is 71.19% similar to enzyme reactant NADPH

5ioq

Flavin-dependent thymidylate synthase in complex with fad and deoxyuridine

Source: Thermotoga maritima (strain atcc 43589 / msb8 / dsm 3109 / jcm 10099). Organism_taxid: 243274. Strain: atcc 43589 / msb8 / dsm 3109 / jcm 10099. Gene: thyx, thy1, tm_0449. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B, C, D (210 residues) CATH domain: 3.30.1360.170

Bound ligands: Het Group DUR is 80.00% similar to enzyme reactant dUMP

Het Group FAD is 71.19% similar to enzyme reactant NADPH

5ior

Flavin-dependent thymidylate synthase in complex with fad and 2'- deoxyuridine-5'-monosulfate

Source: Thermotoga maritima (strain atcc 43589 / msb8 / dsm 3109 / jcm 10099). Organism_taxid: 243274. Strain: atcc 43589 / msb8 / dsm 3109 / jcm 10099. Gene: thyx, thy1, tm_0449. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (216 residues) CATH domain: 3.30.1360.170

Bound ligands: Het Group DUS is 66.67% similar to enzyme reactant dUMP

Het Group FAD is 71.19% similar to enzyme reactant NADPH

5ios

Flavin-dependent thymidylate synthase r90a variant in complex with fad and deoxyuridine monophosphate

Source: Thermotoga maritima (strain atcc 43589 / msb8 / dsm 3109 / jcm 10099). Organism_taxid: 243274. Strain: atcc 43589 / msb8 / dsm 3109 / jcm 10099. Gene: thyx, thy1, tm_0449. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B, C, D (214 residues) CATH domain: 3.30.1360.170

Bound ligands: Het Group UMP corresponds to enzyme reactant dUMP

Het Group FAD is 71.19% similar to enzyme reactant NADPH

5iot

Flavin-dependent thymidylate synthase r174a variant in complex with fad and dump

Source: Thermotoga maritima (strain atcc 43589 / msb8 / dsm 3109 / jcm 10099). Organism_taxid: 243274. Strain: atcc 43589 / msb8 / dsm 3109 / jcm 10099. Gene: thyx, thy1, tm_0449. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B, C, D (215 residues) CATH domain: 3.30.1360.170

Bound ligands: Het Group UMP corresponds to enzyme reactant dUMP

Het Group FAD is 71.19% similar to enzyme reactant NADPH

5jfe

Flavin-dependent thymidylate synthase with h2-dump

Source: Thermotoga maritima (strain atcc 43589 / msb8 / dsm 3109 / jcm 10099). Organism_taxid: 243274. Strain: atcc 43589 / msb8 / dsm 3109 / jcm 10099. Gene: thyx, thy1, tm_0449. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768

Chain: A (213 residues) CATH domain: 3.30.1360.170

Bound ligands: Het Group UMC corresponds to enzyme reactant dUMP

Het Group FAD is 71.19% similar to enzyme reactant NADPH

6j61

Crystal structure of thymidylate synthase, thy1, from thermus thermophilus having an extra c terminal domain

Source: Thermus thermophilus (strain hb8 / atcc 27634 / dsm 579). Organism_taxid: 300852. Strain: hb8 / atcc 27634 / dsm 579. Gene: thyx, ttha1096. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chains: A, B, C, D (242 residues)

Bound ligand: Het Group FAD is 71.19% similar to enzyme reactant NADPH

7ndw

Thyx-fadh2 soaked with 20 mm formaldehyde

Source: Thermotoga maritima. Organism_taxid: 2336. Gene: thyx, thy1, tm_0449. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chains: A, B, C, D (211 residues)

Bound ligand: Het Group HUF is 68.85% similar to enzyme reactant NADPH

7ndz

Thyx reconstituted with n5-carbinolamine flavin

Source: Thermotoga maritima. Organism_taxid: 2336. Gene: thyx, thy1, tm_0449. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chains: A, B, C, D (216 residues)

Bound ligand: Het Group HUF is 68.85% similar to enzyme reactant NADPH

8ren

Crystal structure of reduced thyx

Source: Thermotoga maritima. Organism_taxid: 2336. Gene: thyx, thy1, tm_0449. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chains: A, B, C, D (217 residues)

Bound ligand: Het Group FDA is 71.19% similar to enzyme reactant NADPH

8reo

Crystal structure of reduced thyx in complex with dump

Source: Thermotoga maritima. Organism_taxid: 2336. Gene: thyx, thy1, tm_0449. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chains: A, B, C, D (220 residues)

Bound ligands: Het Group UMP corresponds to enzyme reactant dUMP

Het Group FDA is 71.19% similar to enzyme reactant NADPH

8rep

Crystal structure of oxidized thyx-y91f mutant

Source: Thermotoga maritima. Organism_taxid: 2336. Gene: thyx. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chains: A, B, C, D (215 residues)

Bound ligand: Het Group FAD is 71.19% similar to enzyme reactant NADPH

8req

Crystal structure of reduced thyx-y91f mutant

Source: Thermotoga maritima. Organism_taxid: 2336. Gene: thyx. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chains: A, B, C, D (217 residues)

Bound ligand: Het Group FDA is 71.19% similar to enzyme reactant NADPH