_EC 1.3.5.1 succinate dehydrogenase. 92 PDB entries  
EC 1.-.-.- Oxidoreductases. [21,415 PDB entries]
EC 1.3.-.- Acting on the CH-CH group of donors. [1,313 PDB entries]
EC 1.3.5.- With a quinone or related compound as acceptor. [225 PDB entries]
EC 1.3.5.1 succinate dehydrogenase. [92 PDB entries]
1e7p

Pathway: Citric acid cycle
Reaction: a quinone + succinate = fumarate + a quinol.
 


quinone
 +
succinate
 =
fumarate
 + quinol
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): fumarate reductase (menaquinone). succinate dehydrogenase (menaquinone). succinate dehydrogenase (quinone). succinate dehydrogenase (ubiquinone). succinic dehydrogenase.
Comments: A complex generally comprising an FAD-containing component that also binds the carboxylate substrate (A subunit), a component that contains three different iron-sulfur centers [2Fe-2S], [4Fe-4S], and [3Fe-4S] (B subunit), and a hydrophobic membrane-anchor component (C, or C and d subunits) that is also the site of the interaction with quinones. The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of bacteria and archaea, with the hydrophilic domain extending into the mitochondrial matrix and the cytoplasm, respectively.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 92 PDB entries in enzyme class E.C.1.3.5.1

  PDB code Protein
1e7p
Quinol:fumarate reductase from wolinella succinogenes
Source: Wolinella succinogenes. Vibrio succinogenes. Organism_taxid: 844. Gene: frda, ws0831. Expressed in: wolinella succinogenes. Expression_system_taxid: 844. Gene: frdb, ws0830. Strain: atcc 29543 / dsm 1740 / lmg 7466 / nctc 11488 / fdc 602w. Variant: frdc-e66q.
Chains: A, B, D, E, G, H, J, K (655 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 3.10.20.820
Bound ligands:   Het Group MLA is 50.00% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
1kf6
E. Coli quinol-fumarate reductase with bound inhibitor hqno
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, M, N (577 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligand:   Het Group OAA is 88.89% similar to enzyme reactant succinate
1kfy
Quinol-fumarate reductase with quinol inhibitor 2-[1-(4-chloro- phenyl)-ethyl]-4,6-dinitro-phenol
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, M, N (577 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligand:   Het Group OAA is 88.89% similar to enzyme reactant succinate
1l0v
Quinol-fumarate reductase with menaquinol molecules
Source: Escherichia coli. Organism_taxid: 562. Gene: frda. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: frdb. Gene: frdc. Gene: frdd.
Chains: A, B, M, N (577 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group OAA is 88.89% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
1nek
Complex ii (succinate dehydrogenase) from e. Coli with ubiquinone bound
Source: Escherichia coli. Organism_taxid: 562. Gene: sdha or b0723 or z0877 or ecs0748. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: sdhb or b0724. Gene: sdhc or cyba or b0721 or z0875 or ecs0746. Gene: sdhd or b0722.
Chains: A, B (588 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group OAA is 88.89% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
1nen
Complex ii (succinate dehydrogenase) from e. Coli with dinitrophenol- 17 inhibitor co-crystallized at the ubiquinone binding site
Source: Escherichia coli. Organism_taxid: 562. Gene: sdha or b0723 or z0877 or ecs0748. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: sdhb or b0724. Gene: sdhc or cyba or b0721 or z0875 or ecs0746. Gene: sdhd or b0722.
Chains: A, B (588 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group OAA is 88.89% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
1qlb
Respiratory complex ii-like fumarate reductase from wolinella succinogenes
Source: Wolinella succinogenes. Organism_taxid: 844. Organism_taxid: 844
Chains: A, B, D, E (655 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 3.10.20.820
Bound ligands:   Het Group FUM corresponds to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
1yq3
Avian respiratory complex ii with oxaloacetate and ubiquinone
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organism_taxid: 9031
Chains: A, B, C, D (614 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
1yq4
Avian respiratory complex ii with 3-nitropropionate and ubiquinone
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organism_taxid: 9031
Chains: A, B, C, D (614 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group JZR is 44.44% similar to enzyme reactant quinone
  Het Group 3NP is 55.56% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
1zoy
Crystal structure of mitochondrial respiratory complex ii from porcine heart at 2.4 angstroms
Source: Sus scrofa. Pig. Organism_taxid: 9823. Tissue: porcine heart. Tissue: porcine heart
Chains: A, B (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group UQ1 is 44.44% similar to enzyme reactant quinone
  Het Group FAD corresponds to enzyme cofactor FAD
1zp0
Crystal structure of mitochondrial respiratory complex ii bound with 3-nitropropionate and 2-thenoyltrifluoroacetone
Source: Sus scrofa. Pig. Organism_taxid: 9823. Tissue: porcine heart. Tissue: porcine heart
Chains: A, B (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group TTF is 46.67% similar to enzyme reactant quinone
  Het Group 3NP is 45.45% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
2acz
Complex ii (succinate dehydrogenase) from e. Coli with atpenin a5 inhibitor co-crystallized at the ubiquinone binding site
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (588 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group OAA is 88.89% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
2b76
E. Coli quinol fumarate reductase frda e49q mutation
Source: Escherichia coli. Organism_taxid: 562. Gene: frda. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: frdb. Gene: frdc. Gene: frdd.
Chains: A, B, M, N (577 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligand:   Het Group FLC is 61.54% similar to enzyme reactant succinate
2bs2
Quinol:fumarate reductase from wolinella succinogenes
Source: Wolinella succinogenes. Organism_taxid: 844. Organism_taxid: 844
Chains: A, B, D, E (656 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 3.10.20.820
Bound ligands:   Het Group FUM corresponds to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
2bs3
Glu c180 -> gln variant quinol:fumarate reductase from wolinella succinogenes
Source: Wolinella succinogenes. Organism_taxid: 844. Organism_taxid: 844
Chains: A, B, D, E (656 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 3.10.20.820
Bound ligands:   Het Group CIT is 61.54% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
2bs4
Glu c180 -> ile variant quinol:fumarate reductase fromwolinella succinogenes
Source: Wolinella succinogenes. Organism_taxid: 844. Organism_taxid: 844
Chains: A, B, D, E (656 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 3.10.20.820
Bound ligands:   Het Group DMW is 57.14% similar to enzyme reactant quinone
  Het Group CIT is 61.54% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
2fbw
Avian respiratory complex ii with carboxin bound
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organism_taxid: 9031
Chains: A, B, N, O (612 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
2h88
Avian mitochondrial respiratory complex ii at 1.8 angstrom resolution
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organism_taxid: 9031
Chains: A, B, C, D, N, O, P, Q (612 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group BHG is 44.44% similar to enzyme reactant quinone
  Het Group TEO is 88.89% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
2h89
Avian respiratory complex ii with malonate bound
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organism_taxid: 9031
Chains: A, B, C, D (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
2wdq
E. Coli succinate:quinone oxidoreductase (sqr) with carboxin bound
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H, I, J, K, L (588 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group TEO is 88.89% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
2wdr
E. Coli succinate:quinone oxidoreductase (sqr) with pentachlorophenol bound
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H, I, J, K, L (588 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group TEO is 88.89% similar to enzyme reactant succinate
  Het Group PCI is 53.85% similar to enzyme reactant quinone
  Het Group FAD corresponds to enzyme cofactor FAD
2wdv
E. Coli succinate:quinone oxidoreductase (sqr) with an empty quinone- binding pocket
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H, I, J, K, L (588 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group TEO is 88.89% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
2wp9
Crystal structure of the e. Coli succinate:quinone oxidoreductase (sqr) sdhb his207thr mutant
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H, I, J, K, L (588 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group TEO is 88.89% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
2wqy
Remodelling of carboxin binding to the q-site of avian respiratory complex ii
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organism_taxid: 9031
Chains: A, B, C, D, N, O, P, Q (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
2ws3
Crystal structure of the e. Coli succinate:quinone oxidoreductase (sqr) sdhd tyr83phe mutant
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H, I, J, K, L (588 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group TEO is 88.89% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
2wu2
Crystal structure of the e. Coli succinate:quinone oxidoreductase (sqr) sdhc his84met mutant
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H, I, J, K, L (588 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group TEO is 88.89% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
2wu5
Crystal structure of the e. Coli succinate:quinone oxidoreductase (sqr) sdhd his71met mutant
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H, I, J, K, L (588 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group TEO is 88.89% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
3abv
Crystal structure of porcine heart mitochondrial complex ii bound with n-biphenyl-3-yl-2-trifluoromethyl-benzamide
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: heart. Tissue: muscle. Tissue: muscle
Chains: A, B (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
3ae1
Crystal structure of porcine heart mitochondrial complex ii bound with n-phenyl-2-(trifluoromethyl)-benzamide
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: heart. Tissue: muscle. Tissue: muscle
Chains: A, B (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
3ae2
Crystal structure of porcine heart mitochondrial complex ii bound with 2-hydroxy-n-phenyl-benzamide
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: heart. Tissue: muscle. Tissue: muscle
Chains: A, B (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
3ae3
Crystal structure of porcine heart mitochondrial complex ii bound with 2-nitro-n-phenyl-benzamide
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: heart. Tissue: muscle. Tissue: muscle
Chains: A, B (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
3ae4
Crystal structure of porcine heart mitochondrial complex ii bound with 2-iodo-n-methyl-benzamide
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: heart. Tissue: muscle. Tissue: muscle
Chains: A, B (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
3ae5
Crystal structure of porcine heart mitochondrial complex ii bound with 2-methyl-n-(3-isopropoxy-phenyl)-benzamide
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: heart. Tissue: muscle. Tissue: muscle
Chains: A, B (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group MLI is 50.00% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
3ae6
Crystal structure of porcine heart mitochondrial complex ii bound with n-(3-isopropoxy-phenyl)-phthalamicacid
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: heart. Tissue: muscle. Tissue: muscle
Chains: A, B (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
3ae7
Crystal structure of porcine heart mitochondrial complex ii bound with 2-iodo-n-(3-isopropoxy-phenyl)-benzamide
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: heart. Tissue: muscle. Tissue: muscle
Chains: A, B (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
3ae8
Crystal structure of porcine heart mitochondrial complex ii bound with n-(3-isopropoxy-phenyl)-2-trifluoromethylbenzamide
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: heart. Tissue: muscle. Tissue: muscle
Chains: A, B (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
3ae9
Crystal structure of porcine heart mitochondrial complex ii bound with n-(3-pentafluorophenyloxy-phenyl)-2-trifluoromethyl-benzamide
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: heart. Tissue: muscle. Tissue: muscle
Chains: A, B (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group MLI is 50.00% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
3aea
Crystal structure of porcine heart mitochondrial complex ii bound with n-(3-dimethylaminomethyl-phenyl)-2-trifluoromethyl-benzamide
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: heart. Tissue: muscle. Tissue: muscle
Chains: A, B (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group MLI is 50.00% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
3aeb
Crystal structure of porcine heart mitochondrial complex ii bound with n-(3-phenoxy-phenyl)-2-trifluoromethyl-benzamide
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: heart. Tissue: muscle. Tissue: muscle
Chains: A, B (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
3aec
Crystal structure of porcine heart mitochondrial complex ii bound with 2-iodo-n-(1-methylethyl)-benzamid
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: heart. Tissue: muscle. Tissue: muscle
Chains: A, B (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group EBM is 40.00% similar to enzyme reactant quinone
  Het Group FAD corresponds to enzyme cofactor FAD
3aed
Crystal structure of porcine heart mitochondrial complex ii bound with 2-iodo-n-phenyl-benzamide
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: heart. Tissue: muscle. Tissue: muscle
Chains: A, B (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group MLI is 50.00% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
3aee
Crystal structure of porcine heart mitochondrial complex ii bound with atpenin a5
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: heart. Tissue: muscle. Tissue: muscle
Chains: A, B (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
3aef
Crystal structure of porcine heart mitochondrial complex ii with an empty quinone-binding pocket
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: heart. Tissue: muscle. Tissue: muscle
Chains: A, B (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
3aeg
Crystal structure of porcine heart mitochondrial complex ii bound with n-biphenyl-3-yl-2-iodo-benzamide
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: heart. Tissue: muscle. Tissue: muscle
Chains: A, B (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
3cir
E. Coli quinol fumarate reductase frda t234a mutation
Source: Escherichia coli. Organism_taxid: 562. Gene: frda. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: frdb. Gene: frdc. Gene: frdd.
Chains: A, B, M, N (541 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
3p4p
Crystal structure of menaquinol:fumarate oxidoreductase in complex with fumarate
Source: Escherichia coli 042. Organism_taxid: 216592. Strain: 042 / eaec. Gene: frda, ec042_4630. Expressed in: escherichia coli. Expression_system_taxid: 562. Escherichia coli 536. Organism_taxid: 362663. Strain: 536 / upec.
Chains: A, B, M, N (577 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligand:   Het Group FUM corresponds to enzyme reactant succinate
3p4q
Crystal structure of menaquinol:oxidoreductase in complex with oxaloacetate
Source: Escherichia coli 042. Organism_taxid: 216592. Strain: 042 / eaec. Gene: frda, ec042_4630. Expressed in: escherichia coli. Expression_system_taxid: 562. Escherichia coli 536. Organism_taxid: 362663. Strain: 536 / upec.
Chains: A, B, M, N (577 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group OAA is 88.89% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
3p4r
Crystal structure of menaquinol:fumarate oxidoreductase in complex with glutarate
Source: Escherichia coli 042. Organism_taxid: 216592. Strain: 042/eaec. Gene: ec042_4630, frda, sdy_4398. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: frdb, ec042_4629. Escherichia coli o55:h7. Organism_taxid: 701177.
Chains: A, B, M, N (577 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group GUA is 54.55% similar to enzyme reactant quinone
  Het Group FAD corresponds to enzyme cofactor FAD
3p4s
Crystal structure of menaquinol:fumarate oxidoreductase in complex with a 3-nitropropionate adduct
Source: Escherichia coli 042. Organism_taxid: 216592. Strain: 042/eaec. Gene: ec042_4630, frda, sdy_4398. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: frdb, ec042_4629. Escherichia coli o55:h7 str. Cb9615. Organism_taxid: 701177.
Chains: A, B, M, N (577 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group 3NP is 55.56% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
3sfd
Crystal structure of porcine mitochondrial respiratory complex ii bound with oxaloacetate and pentachlorophenol
Source: Sus scrofa. Pigs. Organism_taxid: 9823. Organism_taxid: 9823
Chains: A, B (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group PCI is 53.85% similar to enzyme reactant quinone
  Het Group OAA is 88.89% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
3sfe
Crystal structure of porcine mitochondrial respiratory complex ii bound with oxaloacetate and thiabendazole
Source: Sus scrofa. Pigs. Organism_taxid: 9823. Organism_taxid: 9823
Chains: A, B (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
3vr8
Mitochondrial rhodoquinol-fumarate reductase from the parasitic nematode ascaris suum
Source: Ascaris suum. Pig roundworm. Organism_taxid: 6253. Organelle: mitochondria. Organelle: mitochondria
Chains: A, B, E, F (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group RQX is 42.11% similar to enzyme reactant quinone
  Het Group MLI is 50.00% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
3vr9
Mitochondrial rhodoquinol-fumarate reductase from the parasitic nematode ascaris suum with the specific inhibitor flutolanil
Source: Ascaris suum. Pig roundworm. Organism_taxid: 6253. Organelle: mitochondria. Organelle: mitochondria
Chains: A, B, E, F (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group MLI is 50.00% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
3vra
Mitochondrial rhodoquinol-fumarate reductase from the parasitic nematode ascaris suum with the specific inhibitor atpenin a5
Source: Ascaris suum. Pig roundworm. Organism_taxid: 6253. Organelle: mitochondria. Other_details: adult. Other_details: adult
Chains: A, B, E, F (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group MLI is 50.00% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
3vrb
Mitochondrial rhodoquinol-fumarate reductase from the parasitic nematode ascaris suum with the specific inhibitor flutolanil and substrate fumarate
Source: Ascaris suum. Pig roundworm. Organism_taxid: 6253. Organelle: mitochondria. Other_details: adult. Other_details: adult
Chains: A, B, E, F (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group FUM corresponds to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
4kx6
Plasticity of the quinone-binding site of the complex ii homolog quinol:fumarate reductase
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: frda, b4154, jw4115. Expressed in: escherichia coli. Expression_system_taxid: 562. Organism_taxid: 595496. Strain: k12 / mc4100 / bw2952. Gene: frdb, bwg_3868.
Chains: A, M (577 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
4ysx
Crystal structure of mitochondrial rhodoquinol-fumarate reductase from ascaris suum with the specific inhibitor nn23
Source: Ascaris suum. Pig roundworm. Organism_taxid: 6253. Organism_taxid: 6253
Chains: A, B, E, F (616 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group MLI is 50.00% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
4ysy
Crystal structure of mitochondrial rhodoquinol-fumarate reductase from ascaris suum with n-[(2,4-dichlorophenyl)methyl]-2-(trifluoromethyl) benzamide
Source: Ascaris suum. Pig roundworm. Organism_taxid: 6253. Organism_taxid: 6253
Chains: A, B, E, F (616 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group MLI is 50.00% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
4ysz
Crystal structure of mitochondrial rhodoquinol-fumarate reductase from ascaris suum with 2-iodo-n-[3-(1-methylethoxy)phenyl]benzamide
Source: Ascaris suum. Pig roundworm. Organism_taxid: 6253. Organism_taxid: 6253
Chains: A, B, E, F (616 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group MLI is 50.00% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
4yt0
Crystal structure of mitochondrial rhodoquinol-fumarate reductase from ascaris suum with 2-methyl-n-[3-(1-methylethoxy)phenyl]benzamide.
Source: Ascaris suum. Pig roundworm. Organism_taxid: 6253. Organism_taxid: 6253
Chains: A, B, E, F (616 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group MLI is 50.00% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
4ytm
Crystal structure of mitochondrial rhodoquinol-fumarate reductase from ascaris suum with n-biphenyl-3-yl-2-(trifluoromethyl)benzamide
Source: Ascaris suum. Pig roundworm. Organism_taxid: 6253. Organism_taxid: 6253
Chains: A, B, E, F (616 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group MLI is 50.00% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
4ytn
Crystal structure of mitochondrial rhodoquinol-fumarate reductase from ascaris suum with n-[3-(pentafluorophenoxy)phenyl]-2- (trifluoromethyl)benzamide
Source: Ascaris suum. Pig roundworm. Organism_taxid: 6253. Organism_taxid: 6253
Chains: A, B, E, F (616 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group MLI is 50.00% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
4ytp
Crystal structure of porcine heart mitochondrial complex ii bound with n-[(4-tert-butylphenyl)methyl]-2-(trifluoromethyl)benzamide
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organism_taxid: 9823
Chains: A, B (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
4yxd
Crystal structure of porcine heart mitochondrial complex ii bound with flutolanil
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organism_taxid: 9823
Chains: A, B (613 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
5c2t
Crystal structure of mitochondrial rhodoquinol-fumarate reductase from ascaris suum with rhodoquinone-2
Source: Ascaris suum. Pig roundworm. Organism_taxid: 6253. Organism_taxid: 6253
Chains: A, B, E, F (616 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group MLI is 50.00% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
5c3j
Crystal structure of mitochondrial rhodoquinol-fumarate reductase from ascaris suum with ubiquinone-1
Source: Ascaris suum. Pig roundworm. Organism_taxid: 6253. Organism_taxid: 6253
Chains: A, B, E, F (616 residues) CATH domains: 3.50.50.60 3.90.700.10 1.20.58.100 4.10.80.40
Bound ligands:   Het Group UQ1 is 44.44% similar to enzyme reactant quinone
  Het Group MLI is 50.00% similar to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
5vpn
E. Coli quinol fumarate reductase frda e245q mutation
Source: Escherichia coli (strain k12). Organism_taxid: 83333. Strain: k12. Gene: frda, b4154, jw4115. Expressed in: escherichia coli. Expression_system_taxid: 562. Escherichia coli. Organism_taxid: 562. Gene: frdc, b4152, jw4113.
Chains: A, B, E, F (577 residues)
5xmj
Crystal structure of quinol:fumarate reductase from desulfovibrio gigas
Source: Desulfovibrio gigas. Organism_taxid: 879. Desulfovibrio gigas dsm 1382 = atcc 19364. Organism_taxid: 1121448. Organism_taxid: 879
Chains: A, B, E, F, I, J, M, N (622 residues)
Bound ligands:   Het Group FUM corresponds to enzyme reactant succinate
  Het Group FAD corresponds to enzyme cofactor FAD
6awf
Escherichia coli quinol:fumarate reductase crystallized without dicarboxylate
Source: Escherichia coli. Organism_taxid: 562. Gene: frda, b4154, jw4115. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: frdb, z5760, ecs5134. Gene: frdc, ecs88_4740. Gene: frdd, ecs88_4739. Expression_system_taxid: 562
Chains: A, B, E, F (573 residues)
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
6b58
Frda-sdhe assembly intermediate
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, C (542 residues)
Bound ligands:   Het Group MLI is 50.00% similar to enzyme reactant succinate
  Het Group GOL is 40.00% similar to enzyme reactant quinone
6c12
Sdha-sdhe complex
Source: Escherichia coli (strain k12). Organism_taxid: 83333. Strain: k12. Gene: sdha, b0723, jw0713. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: sdhe, cptb, ygfy, b2897, jw2865. Expression_system_taxid: 562
Chains: B, A (537 residues)
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
6lum
Structure of mycobacterium smegmatis succinate dehydrogenase 2
Source: Mycolicibacterium smegmatis mc2 51. Organism_taxid: 1445611. Strain: mc2 51. Strain: mc2 51
Chains: A, B, J, K, P, Q (539 residues)
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
6myo
Avian mitochondrial complex ii with flutolanyl bound
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Organ: heart
Chains: A, B, C (612 residues)
6myp
Avian mitochondrial complex ii with ttfa (thenoyltrifluoroacetone) bound
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Organ: heart
Chains: A, B, C (612 residues)
6myq
Avian mitochondrial complex ii with ferulenol bound
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Organ: heart
Chains: A, B, C (611 residues)
6myr
Avian mitochondrial complex ii with thiapronil bound
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Organ: heart
Chains: A, B, C (611 residues)
6mys
Avian mitochondrial complex ii with atpenin a5 bound, sidechain outside
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Organ: heart
Chains: A, B, C (612 residues)
6myt
Avian mitochondrial complex ii with atpenin a5 bound, sidechain in pocket
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Organ: heart
Chains: A, B, C (611 residues)
6myu
Avian mitochondrial complex ii crystallized in the presence of hqno
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Organ: heart
Chains: A, B, C (611 residues)
6n56
Crystal structure of fumarate reductase, flavo protein subunit, from helicobacter pylori g27
Source: Helicobacter pylori (strain g27). Organism_taxid: 563041. Strain: g27. Gene: frda, hpg27_176. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768.
Chain: A (632 residues)
6vax
Crystal structure of human sdha-sdhaf2 assembly intermediate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: sdha, sdh2, sdhf. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Gene: sdhaf2, c11orf79, pgl2, sdh5. Expression_system_taxid: 83333
Chains: A, C (611 residues)
6wu6
Succinate-coenzyme q reductase
Source: Escherichia coli. Organism_taxid: 562. Gene: sdhb. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: sdhc, cyba, dhsc. Escherichia coli 908573. Organism_taxid: 1268998. Gene: hmpref1611_01928.
Chains: B, C, F, G, J, K (238 residues)
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
7jz2
Succinate: quinone oxidoreductase sqr from e.Coli k12
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Strain: k-12
Chains: A, B, E, F, I, J (481 residues)
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
7kcl
Full-length human mitochondrial hsp90 (trap1) in complex with sdhb in the presence of amp-pnp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: trap1, hsp75. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: sdhb, sdh, sdh1. Expression_system_taxid: 562
Chain: C (23 residues)
Bound ligand:   Het Group ANP is 44.83% similar to enzyme cofactor FAD
7kcm
Full-length human mitochondrial hsp90 (trap1) in complex with sdhb in the presence of amp-pnp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: trap1, hsp75. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: sdhb, sdh, sdh1. Expression_system_taxid: 562
Chain: C (121 residues)
Bound ligand:   Het Group ANP is 44.83% similar to enzyme cofactor FAD
7klu
Tetrameric human mitochondrial hsp90 (trap1) in the presence of amp- pnp
Source: Homo sapiens, synthetic construct. Human. Organism_taxid: 9606, 32630. Gene: trap1, hsp75. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: trap1, hsp75, sdhb, sdh, sdh1. Expression_system_taxid: 562
Chains: B, C ( residues)
Bound ligand:   Het Group ANP is 44.83% similar to enzyme cofactor FAD
7klv
Full-length human mitochondrial hsp90 (trap1) spycatcher/spytag-sdhb heterodimer in the presence of amp-pnp
Source: Homo sapiens, synthetic construct. Human. Organism_taxid: 9606, 32630. Gene: trap1, hsp75. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: trap1, hsp75, sdhb, sdh, sdh1. Expression_system_taxid: 562
Chain: B ( residues)
Bound ligand:   Het Group ANP is 44.83% similar to enzyme cofactor FAD
8dyd
Crystal structure of human sdha-sdhaf2-sdhaf4 assembly intermediate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: sdha, sdh2, sdhf. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Gene: sdhaf2, c11orf79, pgl2, sdh5. Gene: sdhaf4, c6orf57. Expressed in: escherichia coli bl21.
Chain: A (610 residues)
8dye
Crystal structure of human sdha-sdhaf4 assembly intermediate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: sdha, sdh2, sdhf. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Gene: sdhaf4, c6orf57. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (611 residues)
8gs8
Cryo-em structure of the human respiratory complex ii
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: sdha, sdh2, sdhf. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: sdhb. Gene: sdhc, cyb560, sdh3. Gene: sdhd.
Chains: A, B (614 residues)
Bound ligands:   Het Group UQ1 is 44.44% similar to enzyme reactant quinone
  Het Group FAD corresponds to enzyme cofactor FAD
9kps
Cryo-em structure of saccharomyces cerevisiae mitochondrial respiratory complex ii
Source: Saccharomyces cerevisiae. Brewer's yeast. Organism_taxid: 4932. Strain: redstar. Strain: redstar
Chains: A, B (593 residues)
Bound ligand:   Het Group FAD corresponds to enzyme cofactor FAD
9kpt
Cryo-em structure of saccharomyces cerevisiae mitochondrial respiratory complex ii in uq1-bound state
Source: Saccharomyces cerevisiae. Brewer's yeast. Organism_taxid: 4932. Strain: redstar. Strain: redstar
Chains: A, B (593 residues)
Bound ligands:   Het Group UQ1 is 44.44% similar to enzyme reactant quinone
  Het Group FAD corresponds to enzyme cofactor FAD