_EC 1.2.1.79 succinate-semialdehyde dehydrogenase (NADP(+)). 6 PDB entries  
EC 1.-.-.- Oxidoreductases. [21,484 PDB entries]
EC 1.2.-.- Acting on the aldehyde or oxo group of donors. [1,276 PDB entries]
EC 1.2.1.- With NAD(+) or NADP(+) as acceptor. [958 PDB entries]
EC 1.2.1.79 succinate-semialdehyde dehydrogenase (NADP(+)). [6 PDB entries]
3jz4

Reaction: succinate semialdehyde + NADP(+) + H2O = succinate + Nadph + 2 H(+).
 


succinate semialdehyde
 +
NADP(+)
 + H2O
 =
succinate
 +
NADPH
 + 2 × H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Comments: This enzyme participates in the degradation of glutamate and 4-aminobutyrate. It is similar to Ec 1.2.1.24 and Ec 1.2.1.16 but is specific for NADP(+). The enzyme from Escherichia coli is 20-fold more active with NADP(+) than NAD(+).
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 6 PDB entries in enzyme class E.C.1.2.1.79

  PDB code Protein
3jz4
Crystal structure of e. Coli NADP dependent enzyme
Source: Escherichia coli. Organism_taxid: 562. Strain: mc1061. Gene: b2661, gabd, jw2636, na. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (481 residues) CATH domains: 3.40.605.10 3.40.309.10
Bound ligand:   Het Group NAP corresponds to enzyme reactant NADP(+)
4ogd
Crystal structure of succinic semialdehyde dehydrogenase from streptococcus pyogenes in complex with NADP+ as the cofactor
Source: Streptococcus pyogenes mgas1882. Organism_taxid: 1010840. Strain: streptococcus pyogenes. Gene: gabd, mgas1882_0809. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (455 residues) CATH domains: 3.40.605.10 3.40.309.10
4oht
Crystal structure of succinic semialdehyde dehydrogenase from streptococcus pyogenes in complex with NADP+ as the cofactor
Source: Streptococcus pyogenes mgas1882. Organism_taxid: 1010840. Strain: streptococcus pyogenes. Gene: gabd, mgas1882_0809. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (455 residues) CATH domains: 3.40.605.10 3.40.309.10
Bound ligand:   Het Group NAP is 64.58% similar to enzyme reactant NADP(+)
4ywu
Structural insight into the substrate inhibition mechanism of NADP+- dependent succinic semialdehyde dehydrogenase from streptococcus pyogenes
Source: Streptococcus pyogenes mgas1882. Organism_taxid: 1010840. Strain: mgas1882. Gene: gabd. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (455 residues) CATH domains: 3.40.605.10 3.40.309.10
Bound ligand:   Het Group SSN corresponds to enzyme reactant succinate semialdehyde
4ywv
Structural insight into the substrate inhibition mechanism of NADP+- dependent succinic semialdehyde dehydrogenase from streptococcus pyogenes
Source: Streptococcus pyogenes mgas1882. Organism_taxid: 1010840. Strain: mgas1882. Gene: gabd. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (455 residues) CATH domains: 3.40.605.10 3.40.309.10
Bound ligand:   Het Group SSN corresponds to enzyme reactant succinate semialdehyde
8hap
Crystal structure of thermostable acetaldehyde dehydrogenase from hyperthermophilic archaeon sulfolobus tokodaii
Source: Sulfurisphaera tokodaii. Organism_taxid: 111955. Gene: ha332_07780. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (466 residues)
Bound ligand:   Het Group NA7 is 81.25% similar to enzyme reactant NADP(+)