_EC 1.14.18.9 4alpha-methylsterol monooxygenase.

0 PDB entries

EC 1.-.-.- Oxidoreductases. [21,484 PDB entries] EC 1.14.-.- Acting on paired donors, with incorporation or reduction of molecu [4,719 PDB entries] EC 1.14.18.- With another compound as one donor, and incorporation of one atom [91 PDB entries] EC 1.14.18.9 4alpha-methylsterol monooxygenase. [-]

Reaction:		4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 3 O2 + 5 H(+) = 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O.
		4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 × Fe(II)-[cytochrome b5] + 3 × O2 + 5 × H(+) = 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 × Fe(III)-[cytochrome b5] + 4 × H2O Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Other name(s):		4-methylsterol oxidase. methylsterol hydroxylase. methylsterol monooxygenase.
Comments:		This enzyme is found in fungi and animals and catalyzes a step in the biosynthesis of important sterol molecules such as ergosterol and cholesterol, respectively. The enzyme acts on the 4alpha-methyl group. Subsequent decarboxylation by Ec 1.1.1.170 occurs concomitantly with epimerization of the remaining 4beta-methyl into the 4alpha position, thus making it a suitable substrate for a second round of catalysis. cf. Ec 1.14.13.246, Ec 1.14.18.10 and Ec 1.14.18.11. Formerly Ec 1.14.13.72 and Ec 1.14.99.16.
Links:		[IntEnz]   [ExPASy]   [KEGG]

There are no PDB entries in enzyme class E.C.1.14.18.9