_EC 1.14.14.185 taxane 9alpha-hydroxylase. 0 PDB entries  
EC 1.-.-.- Oxidoreductases. [21,435 PDB entries]
EC 1.14.-.- Acting on paired donors, with incorporation or reduction of molecu [4,709 PDB entries]
EC 1.14.14.- With reduced flavin or flavoprotein as one donor, and incorporati [1,155 PDB entries]
EC 1.14.14.185 taxane 9alpha-hydroxylase. [-]

Reaction: 4alpha,5beta-5,20-epoxytax-11-ene-4-ol + reduced [NADPH--hemoprotein reductase] + O2 = 4alpha,5beta-5,20-epoxytax-11-ene-4,9-diol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+).
 

4alpha,5beta-5,20-epoxytax-11-ene-4-ol
+ reduced [NADPH--hemoprotein reductase]
+
O2
= 4alpha,5beta-5,20-epoxytax-11-ene-4,9-diol
+ oxidized [NADPH--hemoprotein reductase]
+ H2O
+ H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): CYP725A22. taxoid 9alpha hydroxylase.
Comments: The enzyme is active in the biosynthetic pathway of paclitaxel (Taxol) in Taxus species (yew).
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are no PDB entries in enzyme class E.C.1.14.14.185