_EC 1.14.14.183 taxoid 2alpha-hydroxylase. 0 PDB entries  
EC 1.-.-.- Oxidoreductases. [21,435 PDB entries]
EC 1.14.-.- Acting on paired donors, with incorporation or reduction of molecu [4,709 PDB entries]
EC 1.14.14.- With reduced flavin or flavoprotein as one donor, and incorporati [1,155 PDB entries]
EC 1.14.14.183 taxoid 2alpha-hydroxylase. [-]

Reaction: (1) taxusin + reduced [NADPH--hemoprotein reductase] + O2 = 2alpha- hydroxytaxusin + oxidized [NADPH--hemoprotein reductase] + H2O + H(+). (2) 7beta-hydroxytaxusin + reduced [NADPH--hemoprotein reductase] + O2 = 2alpha,7beta-dihydroxytaxusin + oxidized [NADPH--hemoprotein reductase] + H2O + H(+).
 

taxusin
 + reduced [NADPH--hemoprotein reductase]
 +
O2
 = 2alpha- hydroxytaxusin
 + oxidized [NADPH--hemoprotein reductase]
 + H2O
 + H(+)
7beta-hydroxytaxusin
 + reduced [NADPH--hemoprotein reductase]
 +
O2
 = 2alpha,7beta-dihydroxytaxusin
 + oxidized [NADPH--hemoprotein reductase]
 + H2O
 + H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Comments: A cytochrome P450 (heme-thiolate) protein from the yew tree Taxus cuspidata. Does not act on earlier intermediates in taxol biosynthesis.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are no PDB entries in enzyme class E.C.1.14.14.183