_EC 1.14.14.132 (-)-4'-demethyl-deoxypodophyllotoxin 4-hydroxylase.

0 PDB entries

EC 1.-.-.- Oxidoreductases. [21,435 PDB entries] EC 1.14.-.- Acting on paired donors, with incorporation or reduction of molecu [4,709 PDB entries] EC 1.14.14.- With reduced flavin or flavoprotein as one donor, and incorporati [1,155 PDB entries] EC 1.14.14.132 (-)-4'-demethyl-deoxypodophyllotoxin 4-hydroxylase. [-]

Reaction:		(-)-4'-desmethyl-deoxypodophyllotoxin + reduced [NADPH--hemoprotein reductase] + O2 = 4'-demethylepipodophyllotoxin + oxidized [NADPH- -hemoprotein reductase] + H2O + H(+).
		(-)-4'-desmethyl-deoxypodophyllotoxin + reduced [NADPH--hemoprotein reductase] + O2 = 4'-demethylepipodophyllotoxin + oxidized [NADPH- -hemoprotein reductase] + H2O + H(+) Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Other name(s):		CYP82D61.
Comments:		A cytochrome P450 (heme-thiolate) protein characterized from the plant Sinopodophyllum hexandrum. The enzyme produces the direct precursor to etoposide, a potent anticancer drug. It can also act on (-)-deoxypodophyllotoxin with lower efficiency. Formerly Ec 1.14.13.214.
Links:		[IntEnz]   [ExPASy]   [KEGG]

There are no PDB entries in enzyme class E.C.1.14.14.132