_EC 1.14.13.195 L-ornithine N(5)-monooxygenase (NADPH).

2 PDB entries

EC 1.-.-.- Oxidoreductases. [21,435 PDB entries] EC 1.14.-.- Acting on paired donors, with incorporation or reduction of molecu [4,709 PDB entries] EC 1.14.13.- With Nadh or nadph as one donor, and incorporation of one atom of [1,069 PDB entries] EC 1.14.13.195 L-ornithine N(5)-monooxygenase (NADPH). [2 PDB entries]

3s5w

Reaction:		L-ornithine + Nadph + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O.
		L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Other name(s):		ornithine hydroxylase.
Comments:		The enzyme is involved in biosynthesis of N(5)-hydroxy-L-ornithine, N(5)-formyl-N(5)-hydroxy-L-ornithine or N(5)-acetyl-N(5)-hydroxy-L- ornithine. These nonproteinogenic amino acids are building blocks of siderophores produced by some bacteria (e.g. Streptomyces coelicolor, Saccharopolyspora erythraea and Pseudomonas aeruginosa). The enzyme is specific for Nadph. cf. Ec 1.14.13.196.
Links:		[IntEnz]   [ExPASy]   [KEGG]

There are 2 PDB entries in enzyme class E.C.1.14.13.195

PDB code		Protein
3s5w		Ornithine hydroxylase (pvda) from pseudomonas aeruginosa Source: Pseudomonas aeruginosa. Organism_taxid: 287. Strain: pao1. Gene: pa2386, pvd-1, pvda. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B (410 residues) CATH domain: 3.50.50.60 Bound ligands:   Het Group ONH is 90.00% similar to enzyme reactant L-ornithine   Het Group FAD corresponds to enzyme cofactor FAD
3s61		Reduced form of ornithine hydroxylase (pvda) from pseudomonas aeruginosa Source: Pseudomonas aeruginosa. Organism_taxid: 287. Strain: pao1. Gene: pa2386, pvd-1, pvda. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B (413 residues) CATH domain: 3.50.50.60 Bound ligands:   Het Group ORN corresponds to enzyme reactant L-ornithine   Het Group NDP corresponds to enzyme reactant NADPH   Het Group FAD corresponds to enzyme cofactor FAD