_EC 1.11.1.9 glutathione peroxidase.

61 PDB entries

EC 1.-.-.- Oxidoreductases. [20,752 PDB entries] EC 1.11.-.- Acting on a peroxide as acceptor. [1,301 PDB entries] EC 1.11.1.- Peroxidases. [1,208 PDB entries] EC 1.11.1.9 glutathione peroxidase. [61 PDB entries]

1g6w

Reaction:		2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
		2 × glutathione + H2O2 = glutathione disulfide + 2 × H2O Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments:		Steroid and lipid hydroperoxides, but not the product of reaction of Ec 1.13.11.12 on phospholipids, can act as acceptor, but more slowly than H2O2 (cf. Ec 1.11.1.12).
Links:		[IntEnz]   [ExPASy]   [KEGG]

There are 61 PDB entries in enzyme class E.C.1.11.1.9

PDB code		Protein
1g6w		Crystal structure of the globular region of the prion protein ure2 from the yeast saccaromyces cerevisiae Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: ure2 or ynl229c or n1165. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B, C, D (234 residues) CATH domains: 3.40.30.10 1.20.1050.10
1g6y		Crystal structure of the globular region of the prion protein ure2 from yeast saccharomyces cerevisiae Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: ure2 or ynl229c or n1165. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B (245 residues) CATH domains: 3.40.30.10 1.20.1050.10
1gp1		The refined structure of the selenoenzyme glutathione peroxidase at 0.2-nm resolution Source: Bos taurus. Bovine. Organism_taxid: 9913. Tissue: erythrocyte Chains: A, B (185 residues) CATH domain: 3.40.30.10
1hqo		Crystal structure of the nitrogen regulation fragment of the yeast prion protein ure2p Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: ure2. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B (227 residues) CATH domains: 3.40.30.10 1.20.1050.10
1jzr		Ure2p in complex with glutathione Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B, C, D (234 residues) CATH domains: 3.40.30.10 1.20.1050.10 Bound ligand:   Het Group GSH corresponds to enzyme reactant glutathione
1k0a		Ure2p in complex with s-hexylglutathione Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B (234 residues) CATH domains: 3.40.30.10 1.20.1050.10 Bound ligand:   Het Group GTX is 76.92% similar to enzyme reactant glutathione
1k0b		Ure2p in complex with glutathione Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B, C, D (223 residues) CATH domains: 3.40.30.10 1.20.1050.10 Bound ligand:   Het Group GSH corresponds to enzyme reactant glutathione
1k0c		Ure2p in complex with s-p-nitrobenzylglutathione Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B, C, D (228 residues) CATH domains: 3.40.30.10 1.20.1050.10 Bound ligand:   Het Group GTB is 66.67% similar to enzyme reactant glutathione
1k0d		Ure2p in complex with glutathione Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B, C, D (221 residues) CATH domains: 3.40.30.10 1.20.1050.10 Bound ligand:   Het Group GSH corresponds to enzyme reactant glutathione
1kcw		X-ray crystal structure of human ceruloplasmin at 3.0 angstroms Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: plasma. Tissue: plasma Chain: A (1017 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420 2.60.40.420 2.60.40.420 2.60.40.420
2f8a		Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 1 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Chains: A, B (186 residues) CATH domain: 3.40.30.10
2gs3		Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 4(gpx4) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx4. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chain: A (171 residues) CATH domain: 3.40.30.10
2he3		Crystal structure of the selenocysteine to cysteine mutant of human glutathionine peroxidase 2 (gpx2) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx2. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (185 residues) CATH domain: 3.40.30.10
2i3y		Crystal structure of human glutathione peroxidase 5 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx5. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chain: A (188 residues) CATH domain: 3.40.30.10
2j5w		Ceruloplasmin revisited: structural and functional roles of various metal cation binding sites Source: Homo sapiens. Human. Organism_taxid: 9606 Chain: A (1029 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420 2.60.40.420 2.60.40.420 2.60.40.420
2jac		Glutaredoxin grx1p c30s mutant from yeast Source: Saccharomyces cerevisiae. Bakers' yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 469008. Chain: A (108 residues) CATH domain: 3.40.30.10 Bound ligand:   Het Group GSH corresponds to enzyme reactant glutathione
2jad		Yellow fluorescent protein - glutaredoxin fusion protein Source: Aequorea victoria, saccharomyces cerevisiae. Organism_taxid: 6100, 4932. Expressed in: escherichia coli. Expression_system_taxid: 469008. Chain: A (347 residues) CATH domains: 2.40.155.10 3.40.30.10
2obi		Crystal structure of the selenocysteine to cysteine mutant of human phospholipid hydroperoxide glutathione peroxidase (gpx4) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx4. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (165 residues) CATH domain: 3.40.30.10
2p31		Crystal structure of human glutathione peroxidase 7 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx7, gpx6. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Chains: A, B (155 residues) CATH domain: 3.40.30.10
2r37		Crystal structure of human glutathione peroxidase 3 (selenocysteine to glycine mutant) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx3, gpxp. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B (191 residues) CATH domain: 3.40.30.10
2rm5		Glutathione peroxidase-type tryparedoxin peroxidase, oxidized form Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: gpx3. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (167 residues) CATH domain: 3.40.30.10
2rm6		Glutathione peroxidase-type tryparedoxin peroxidase, reduced form Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: gpx3. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (167 residues) CATH domain: 3.40.30.10
2v1m		Crystal structure of schistosoma mansoni glutathione peroxidase Source: Schistosoma mansoni. Organism_taxid: 6183. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: adult mixed sex cdna Chain: A (163 residues) CATH domain: 3.40.30.10
2vup		Crystal structure of a type ii tryparedoxin-dependant peroxidase from trypanosoma brucei Source: Trypanosoma brucei. Organism_taxid: 5691. Strain: 427. Expressed in: escherichia coli. Expression_system_taxid: 469008. Chain: A (164 residues) CATH domain: 3.40.30.10
2wgr		Combining crystallography and molecular dynamics: the case of schistosoma mansoni phospholipid glutathione peroxidase Source: Schistosoma mansoni. Organism_taxid: 6183. Expressed in: escherichia coli. Expression_system_taxid: 469008. Chain: A (163 residues) CATH domain: 3.40.30.10
3c1r		Crystal structure of oxidized grx1 Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: s288c. Gene: grx1. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (110 residues) CATH domain: 3.40.30.10
3c1s		Crystal structure of grx1 in glutathionylated form Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: s288c. Gene: grx1. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (107 residues) CATH domain: 3.40.30.10 Bound ligand:   Het Group GSH corresponds to enzyme reactant glutathione
3ctf		Crystal structure of oxidized grx2 Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: s288c. Gene: grx2, ttr, ttr1, ydr513w, d9719.17. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (108 residues) CATH domain: 3.40.30.10
3ctg		Crystal structure of reduced glutaredoxin 2 Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: s288c. Gene: grx2, ttr, ttr1, ydr513w, d9719.17. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (108 residues) CATH domain: 3.40.30.10
3cyn		The structure of human gpx8 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: loc493869. Expressed in: escherichia coli. Expression_system_taxid: 469008. Chains: A, B, C (174 residues) CATH domain: 3.40.30.10
3d4m		Glutaredoxin 2 oxidized structure Source: Saccharomyces cerevisiae. Yeast. Organism_taxid: 4932. Gene: grx2, ttr, ttr1, ydr513w, d9719.17. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (109 residues) CATH domain: 3.40.30.10
3d5j		Structure of yeast grx2-c30s mutant with glutathionyl mixed disulfide Source: Saccharomyces cerevisiae. Yeast. Organism_taxid: 4932. Gene: grx2, ttr, ttr1, ydr513w, d9719.17. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B (112 residues) CATH domain: 3.40.30.10 Bound ligand:   Het Group GSH corresponds to enzyme reactant glutathione
3dwv		Glutathione peroxidase-type tryparedoxin peroxidase, oxidized form Source: Trypanosoma brucei. Organism_taxid: 5691. Gene: gpx3, tb927.7.1140. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B (163 residues) CATH domain: 3.40.30.10
3e0u		Crystal structure of t. Cruzi gpx1 Source: Trypanosoma cruzi. Organism_taxid: 5693. Gene: gpxi. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (153 residues) CATH domain: 3.40.30.10
3kij		Crystal structure of the human pdi-peroxidase Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: homo sapiens. Gene: gpx8, gpx8_human, unq847/pro1785. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: A, B, C (171 residues) CATH domain: 3.40.30.10
4ejx		Structure of ceruloplasmin-myeloperoxidase complex Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606 Chain: A (1034 residues)
4enz		Structure of human ceruloplasmin at 2.6 a resolution Source: Homo sapiens. Human. Organism_taxid: 9606 Chain: A (1029 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420 2.60.40.420 2.60.40.420 2.60.40.420
5h5q		Crystal structure of human gpx4 in complex with gxpep-1 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx4. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Enterobacteria phage t7. Organism_taxid: 10760 Chain: A (165 residues) CATH domain: 3.40.30.10
5h5r		Crystal structure of human gpx4 in complex with gxpep-2 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx4. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Enterobacteria phage t7. Organism_taxid: 10760 Chain: A (169 residues) CATH domain: 3.40.30.10
5h5s		Crystal structure of human gpx4 in complex with gxpep-3 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx4. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Enterobacteria phage t7. Organism_taxid: 10760 Chain: A (164 residues) CATH domain: 3.40.30.10
5l71		Crystal structure of mouse phospholipid hydroperoxide glutathione peroxidase 4 (gpx4) Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: gpx4. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (165 residues) CATH domain: 3.40.30.10
5n0k		Rat ceruloplasmin orthorhombic form Source: Rattus norvegicus. Rat. Organism_taxid: 10116 Chain: A (1034 residues)
5n4l		Rat ceruloplasmin trigonal form Source: Rattus norvegicus. Rat. Organism_taxid: 10116 Chains: A, B (1034 residues)
6elw		High resolution structure of selenocysteine containing human gpx4 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx4. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: selb:kan cys51e. Chain: A (165 residues)
6hkq		Human gpx4 in complex with covalent inhibitor ml162 (s enantiomer) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx4. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (166 residues)
6hn3		Wildtype form (apo) of human gpx4 with se-cys46 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx4. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek-293-6e. Expression_system_organ: human embryonic kidney. Chain: A (167 residues)
6mws		Crystal structure of the reduced grx1 from saccharomyces cerevisiae Source: Saccharomyces cerevisiae s288c. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Gene: grx1, ycl035c, ycl35c. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (108 residues)
7fc2		Crystal structure of gpx6 Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: gpx6. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (195 residues)
7l8k		Crystal structure of human gpx4-u46c Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx4. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (164 residues)
7l8l		Crystal structure of human r152h gpx4-u46c Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx4. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (157 residues)
7l8m		Crystal structure of human gpx4-u46c mutant k48l Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx4. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (165 residues)
7l8q		Crystal structure of human gpx4-u46c with oxidized cys-46 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx4. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (165 residues)
7l8r		Crystal structure of human gpx4-u46c mutant k48a Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx4. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B (164 residues)
7u4i		Crystal structure of human gpx4-u46c-r152h in complex with cds9 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx4. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B (161 residues)
7u4j		Crystal structure of human gpx4-u46c-r152h in complex with tmt10 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx4. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (162 residues)
7u4k		Crystal structure of human gpx4-u46c-r152h in complex with ml162 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx4. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (166 residues)
7u4l		Crystal structure of human gpx4-u46c in complex with mac-5576 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx4. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B, C, D (165 residues)
7u4m		Crystal structure of human gpx4-u46c in complex with loc1886 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx4. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (171 residues)
7u4n		Crystal structure of human gpx4-u46c in complex with rsl3 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx4. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B (163 residues)
8q8j		Crystal structure of human gpx4-r152h Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx4. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (165 residues)
8q8n		Crystal structure of human gpx4-u46c-i129s-l130s Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx4. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (165 residues)