_EC 1.11.1.27 glutathione-dependent peroxiredoxin. 16 PDB entries  
EC 1.-.-.- Oxidoreductases. [21,435 PDB entries]
EC 1.11.-.- Acting on a peroxide as acceptor. [1,311 PDB entries]
EC 1.11.1.- Peroxidases. [1,207 PDB entries]
EC 1.11.1.27 glutathione-dependent peroxiredoxin. [16 PDB entries]
1kcw

Reaction: a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.
 


hydroperoxide
 +
2 × glutathione
 =
alcohol
 +
glutathione disulfide
 + H2O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Comments: Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins. They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins. The peroxidase reaction comprises two steps centered around a redox- active cysteine called the peroxidatic cysteine. All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid). The second step of the peroxidase reaction, the regeneration of
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There are 16 PDB entries in enzyme class E.C.1.11.1.27

  PDB code Protein
1kcw
X-ray crystal structure of human ceruloplasmin at 3.0 angstroms
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: plasma. Tissue: plasma
Chain: A (1017 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420 2.60.40.420 2.60.40.420 2.60.40.420
1nm3
Crystal structure of heamophilus influenza hybrid-prx5
Source: Haemophilus influenzae. Organism_taxid: 727. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (237 residues) CATH domains: 3.40.30.10 3.40.30.10
1prx
Horf6 a novel human peroxidase enzyme
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (220 residues) CATH domains: 3.40.30.10 3.30.1020.10
2j5w
Ceruloplasmin revisited: structural and functional roles of various metal cation binding sites
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: A (1029 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group OXY is 66.67% similar to enzyme reactant hydroperoxide
3uma
Crystal structure of a hypothetical peroxiredoxin protein frm sinorhizobium meliloti
Source: Sinorhizobium meliloti. Organism_taxid: 382. Gene: r00915, smc00072. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C (166 residues) CATH domain: 3.40.30.10
4ejx
Structure of ceruloplasmin-myeloperoxidase complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606
Chain: A (1034 residues)
4enz
Structure of human ceruloplasmin at 2.6 a resolution
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: A (1029 residues) CATH domains: 2.60.40.420 2.60.40.420 2.60.40.420 2.60.40.420 2.60.40.420 2.60.40.420
Bound ligand:   Het Group OXY is 66.67% similar to enzyme reactant hydroperoxide
4f82
X-ray crystal structure of a putative thioredoxin reductase from burkholderia cenocepacia
Source: Burkholderia cenocepacia. Organism_taxid: 216591. Strain: j2315. Gene: bcej2315_33940, bcal3456. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (171 residues) CATH domain: 3.40.30.10
5b6m
Crystal structure of human peroxiredoxin 6 in reduced state
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: prdx6, aop2, kiaa0106. Expressed in: escherichia coli-pichia pastoris shuttle vector ppparg4. Expression_system_taxid: 1182032
Chains: A, B, C, D, E, F (221 residues) CATH domains: 3.40.30.10 3.30.1020.10
5b6n
Crystal structures of human peroxiredoxin 6 in sulfinic acid state
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: prdx6, aop2, kiaa0106. Expressed in: escherichia coli-pichia pastoris shuttle vector ppparg4. Expression_system_taxid: 1182032
Chains: A, B, C, D, E, F (221 residues) CATH domains: 3.40.30.10 3.30.1020.10
5k1g
Crystal structure of reduced prx3 from vibrio vulnificus
Source: Vibrio vulnificus mo6-24/o. Organism_taxid: 914127. Strain: mo6-24/o. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (155 residues)
5k2i
Crystal structure of oxidized prx3 from vibrio vulnificus
Source: Vibrio vulnificus mo6-24/o. Organism_taxid: 914127. Strain: mo6-24/o. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (157 residues)
5k2j
Crystal structure of reduced prx3 in complex with h2o2 from vibrio vulnificus
Source: Vibrio vulnificus mo6-24/o. Organism_taxid: 914127. Strain: mo6-24/o. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F, G, H, I, J, K, L (160 residues)
Bound ligand:   Het Group PEO is 66.67% similar to enzyme reactant hydroperoxide
5n0k
Rat ceruloplasmin orthorhombic form
Source: Rattus norvegicus. Rat. Organism_taxid: 10116
Chain: A (1034 residues)
5n4l
Rat ceruloplasmin trigonal form
Source: Rattus norvegicus. Rat. Organism_taxid: 10116
Chains: A, B (1034 residues)
5ykj
Structural basis of the thiol resolving mechanism in yeast mitochondrial 1-cys peroxiredoxin via glutathione/thioredoxin systems
Source: Saccharomyces cerevisiae (strain atcc 204508 / s288c). Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Gene: prx1, ybl064c, ybl0503, ybl0524. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (213 residues)