_EC 1.11.1.26 NADH-dependent peroxiredoxin. 21 PDB entries  
EC 1.-.-.- Oxidoreductases. [21,484 PDB entries]
EC 1.11.-.- Acting on a peroxide as acceptor. [1,313 PDB entries]
EC 1.11.1.- Peroxidases. [1,209 PDB entries]
EC 1.11.1.26 NADH-dependent peroxiredoxin. [21 PDB entries]
1n8j

Reaction: a hydroperoxide + Nadh + H(+) = an alcohol + NAD(+) + H2O.
 


hydroperoxide
 +
NADH
 + H(+)
 =
alcohol
 +
NAD(+)
 + H2O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): alkyl hydroperoxide reductase.
Comments: Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins. They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins. The peroxidase reaction comprises two steps centered around a redox- active cysteine called the peroxidatic cysteine. All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid). The second step of the peroxidase reaction, the regeneration of
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There are 21 PDB entries in enzyme class E.C.1.11.1.26

  PDB code Protein
1n8j
Crystal structure of ahpc with active site cysteine mutated to serine (c46s)
Source: Salmonella typhimurium. Organism_taxid: 602. Gene: ahpc. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T (186 residues) CATH domain: 3.40.30.10
1we0
Crystal structure of peroxiredoxin (ahpc) from amphibacillus xylanus
Source: Amphibacillus xylanus. Organism_taxid: 1449. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H, I, J (166 residues) CATH domain: 3.40.30.10
1yep
Structural and biochemical analysis of the link between enzymatic activity and olgomerization in ahpc, a bacterial peroxiredoxin.
Source: Salmonella typhimurium. Organism_taxid: 602. Gene: ahpc. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E (168 residues) CATH domain: 3.40.30.10
1yex
Structural and biochemical analysis of the link between enzymatic activity and oligomerization in ahpc, a bacterial peroxiredoxin.
Source: Salmonella typhimurium. Organism_taxid: 602. Gene: ahpc. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E (167 residues) CATH domain: 3.40.30.10
1yf0
Structural and biochemical analysis of the link between enzymatic activity and oligomerization in ahpc, a bacterial peroxiredoxin.
Source: Salmonella typhimurium. Organism_taxid: 602. Gene: ahpc. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E (167 residues) CATH domain: 3.40.30.10
1yf1
Structural and biochemical analysis of the link between enzymatic activity and oligomerization in ahpc, a bacterial peroxiredoxin.
Source: Salmonella typhimurium. Organism_taxid: 602. Gene: ahpc. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F, G, H, I, J (166 residues) CATH domain: 3.40.30.10
1zof
Crystal structure of alkyl hydroperoxide-reductase (ahpc) from helicobacter pylori
Source: Helicobacter pylori. Organism_taxid: 210. Gene: tsaa. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H, I, J (170 residues) CATH domain: 3.40.30.10
3emp
Crystal structure of the s-acetanilide modified form of c165s ahpc
Source: Salmonella typhimurium. Organism_taxid: 602. Gene: ahpc. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E (161 residues) CATH domain: 3.40.30.10
4ma9
Wild type salmonella alkyl hydroperoxide reductasE C in its substrate- ready conformation
Source: Salmonella enterica subsp. Enterica serovar typhimurium. Organism_taxid: 90371. Gene: ahpc, ahpc stm0608, stm0608. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E (163 residues) CATH domain: 3.40.30.10
4mab
Resolving cys to ala variant of salmonella alkyl hydroperoxide reductasE C in its substrate-ready conformation
Source: Salmonella enterica subsp. Enterica serovar typhimurium. Organism_taxid: 90371. Gene: ahpc, ahpc stm0608, stm0608. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E (165 residues) CATH domain: 3.40.30.10
4xra
Salmonella typhimurium ahpc t43s mutant
Source: Salmonella enterica subsp. Enterica serovar typhimurium. Organism_taxid: 90371. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E (168 residues) CATH domain: 3.40.30.10
4xrd
Salmonella typhimurium ahpc w169f mutant
Source: Salmonella enterica subsp. Enterica serovar typhimurium. Organism_taxid: 90371. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E (164 residues) CATH domain: 3.40.30.10
4xs1
Salmonella typhimurium ahpc t43v mutant
Source: Salmonella enterica subsp. Enterica serovar typhimurium. Organism_taxid: 90371. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E (165 residues) CATH domain: 3.40.30.10
4xs4
Salmonella typhimurium ahpc c165s mutant
Source: Salmonella enterica subsp. Enterica serovar typhimurium. Organism_taxid: 90371. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B, C, D, E (167 residues) CATH domain: 3.40.30.10
4xs6
Salmonella typhimurium ahpc w81f mutant
Source: Salmonella enterica subsp. Enterica serovar typhimurium. Organism_taxid: 90371. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E (163 residues) CATH domain: 3.40.30.10
4xts
Salmonella typhimurium ahpc t43a mutant
Source: Salmonella enterica subsp. Enterica serovar typhimurium. Organism_taxid: 90371. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T (160 residues) CATH domain: 3.40.30.10
5b8a
Crystal structure of oxidized chimeric ecahpc1-186-yfskhn
Source: Escherichia coli (strain k12), homo sapiens. Human. Organism_taxid: 83333, 9606. Strain: k12. Gene: ahpc, b0605, jw0598, prdx2, nkefb, tdpx1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F, G, H, I, J (168 residues) CATH domain: 3.40.30.10
5b8b
Crystal structure of reduced chimeric e.Coli ahpc1-186-yfskhn
Source: Escherichia coli (strain k12), homo sapiens. Human. Organism_taxid: 83333, 9606. Strain: k12. Gene: ahpc, b0605, jw0598, prdx2, nkefb, tdpx1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, I, J, C, D, F, E, G, H (165 residues) CATH domain: 3.40.30.10
5uka
Salmonella typhimurium ahpc e49q mutant
Source: Salmonella typhimurium (strain lt2 / sgsc1412 / atcc 700720). Organism_taxid: 99287. Strain: lt2 / sgsc1412 / atcc 700720. Gene: ahpc, stm0608. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E (165 residues)
5y63
Crystal structure of enterococcus faecalis ahpc
Source: Enterococcus faecalis (strain atcc 700802 / v583). Organism_taxid: 226185. Strain: atcc 700802 / v583. Atcc: atcc 700802. Gene: ahpc, ef_2739. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E (167 residues)
7kuu
Lsfa from p. Aeruginosa, a 1-cys prx in sulfonic acid form
Source: Pseudomonas aeruginosa (strain ucbpp-pa14). Organism_taxid: 208963. Strain: ucbpp-pa14. Gene: lsfa, pa14_19490. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (205 residues)