The enzyme catalyzes the ubiquinone reduction linking oxidation of fatty acids and some amino acids to the mitochondrial respiratory chain. It binds three iron-sulfur clusters PMID17050691.
CATALYTIC METAL(S)
| Metal/Site Information | |||||
| Residue in MACiE* | Atom in MACiE* | Residue Type in MACiE | Physiological Metal |
Site Type |
Function(s) |
| SF4 1003 B | FE1 | iron | iron | Fe4S4 | Electron relay |
| F3S 1004 B | FE1 | iron | iron | Fe3S4 | Electron relay |
| none | none | iron | iron | Fe2S2 | Electron relay |
*It refers to the MACiE reference pdb: 1yq4
| Metal/s Properties in Resting State | ||||||
| SF4 1003 B | Resting state enzyme (-) | |||||
| Oxidation State | unknown | |||||
| Coordination Geometry | tetrahedral | |||||
| Coordination Number | 4 | |||||
| Notes | - | |||||
| F3S 1004 B | Resting state enzyme (-) | |||||
| Oxidation State | unknown | |||||
| Coordination Geometry | tetrahedral | |||||
| Coordination Number | 4 | |||||
| Notes | - | |||||
| none | Resting state enzyme (-) | |||||
| Oxidation State | unknown | |||||
| Coordination Geometry | tetrahedral | |||||
| Coordination Number | 4 | |||||
| Notes | - | |||||
| N.B.The coordination number and the geometry refer to each single iron in the iron-sulfur cluster whereas the oxidation state is the formal oxidation state of the whole cluster. | ||||||
| References |
| -Zhang J, Frerman FE, Kim JJ Structure of electron transfer flavoprotein-ubiquinone oxidoreductase and electron transfer to the mitochondrial ubiquinone pool. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16212-7. Epub 2006 Oct 18.(MEDLINE:17050691) |