The enzyme catalyzes the oxidative decarboxylation of the central metabolite pyruvate to carbon dioxide and acetate. It binds a magnesium ion (PMID18988747).
CATALYTIC METAL(S)
| Metal/Site Information | |||||
| Residue in MACiE* | Atom in MACiE* | Residue Type in MACiE | Physiological Metal |
Site Type |
Function(s) |
| MG 616 A | MG | magnesium | magnesium | mononuclear | Coordinates substrate |
*It refers to the MACiE reference pdb: 3ey9
| Metal/s Properties in Resting State | ||||||
| MG 616 A | Resting state enzyme (-) | |||||
| Oxidation State | 2 | |||||
| Coordination Geometry | unknownGeometry | |||||
| Coordination Number | unknown | |||||
| Notes | - | |||||
| References |
| -Weidner A, Pech A, Stubbs MT, Tittmann K Structural basis for membrane binding and catalytic activation of the peripheral membrane enzyme pyruvate oxidase from Escherichia coli. Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17390-5. Epub 2008 Nov 6.(MEDLINE:18988747) |