The enzyme catalyzes the Ca2+-dependent hydrolysis of both DNA and RNA at the 5 position of the phosphodiester bond yielding a free 5-hydroxyl group and a 3-phosphate monoester (PMID288045).
CA 1 x IN THE RESTING STATE ENZYME
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Representative PDB structure for CA 1 x in the resting state enzyme | |
| PDB code | 1ena | |
| Metal Type in the PDB | calcium | |
| Residue name of the metal in the PDB | CA | |
| Residue number of the metal in the PDB | 142 | |
| Chain of the metal in the PDB | _ | |
| Atom name of the metal in the PDB | CA | |
| Download the coordinates file of the metal site | NOTES ON PDB: | |
| First Coordination Sphere | ||||||
| Ligand Type | Ligand Identity | Residue In MACiE | Donors | Bind Mode | Catalytic? | Notes |
| residue | GLU 21 _ | - | OE1,OE2 | bidentate | No | - |
| residue | ASP 40 _ | ASP 40 _ | OD1 | monodentate | No | - |
| residue | THR 41 _ | THR 41 _ | O | monodentate | No | - |
| residue | GLU 43 _ | GLU 43 _ | OE2 | monodentate | Yes | Glu43 is involved in electron relay. |