The enzyme catalyzes the conversion of tyrosine to dihydroxyphenylalanine. It is a homotetramer and each subunits binds a catalytic iron (PMID9228951).
FE 501 x IN THE RESTING STATE ENZYME
 |
Representative PDB structure for FE 501 x in the resting state enzyme | |
| PDB code | 1toh | |
| Metal Type in the PDB | iron | |
| Residue name of the metal in the PDB | FE | |
| Residue number of the metal in the PDB | 501 | |
| Chain of the metal in the PDB | _ | |
| Atom name of the metal in the PDB | FE | |
| Download the coordinates file of the metal site | NOTES ON PDB: | |
| First Coordination Sphere | ||||||
| Ligand Type | Ligand Identity | Residue In MACiE | Donors | Bind Mode | Catalytic? | Notes |
| residue | HIS 331 _ | HIS 331 A | NE2 | monodentate | Yes | His331 is an electrostatic stabilizer |
| residue | HIS 336 _ | HIS 336 A | NE2 | monodentate | No | - |
| residue | GLU 376 _ | GLU 376 A | OE1,OE2 | bidentate | No | - |
| water | HOH 601 _ | - | O | monodentate | No | - |
| water | HOH 602 _ | - | O | monodentate | No | - |