The enzyme catalyzes the the oxidation of sulfite to sulfate with the reduction of two equivalents of ferricytochrome c. It contains a molybdopterin cofactor (PMID12424234).
CATALYTIC METAL(S)
| Metal/Site Information | |||||
| Residue in MACiE* | Atom in MACiE* | Residue Type in MACiE | Physiological Metal |
Site Type |
Function(s) |
| MO 505 A | MO | molybdenum | molybdenum | molybdopterin | Coordinates substrate One electron donor Electron pair acceptor Increases acidity |
| HEM 502 A | FE | iron | iron | haem | Electron relay |
*It refers to the MACiE reference pdb: 1sox
| Metal/s Properties in Resting State | ||||||
| MO 505 A | Resting state enzyme (2a9b) | |||||
| Oxidation State | 6 | |||||
| Coordination Geometry | squarePyramidal | |||||
| Coordination Number | 5 | |||||
| Notes | - | |||||
| HEM 502 A | Resting state enzyme (-) | |||||
| Oxidation State | 3 | |||||
| Coordination Geometry | octahedral | |||||
| Coordination Number | 6 | |||||
| Notes | - | |||||
| References |
| -Feng C, Wilson HL, Hurley JK, Hazzard JT, Tollin G, Rajagopalan KV, Enemark JH Role of conserved tyrosine 343 in intramolecular electron transfer in human sulfite oxidase. J Biol Chem. 2003 Jan 31;278(5):2913-20. Epub 2002 Nov 6.(MEDLINE:12424234) |
| - Some information have been also deduced from the MACiE mechanism model |