The enzyme catalyzes the thiamine PPi- and Mg2+-dependent decarboxylation of pyruvate to acetaldehyde and carbon dioxide (PMID10919763).
MG 1368 C IN THE RESTING STATE ENZYME
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Representative PDB structure for MG 1368 C in the resting state enzyme | |
|   | ||
| PDB code | 1w88 | |
| Metal Type in the PDB | magnesium | |
| Residue name of the metal in the PDB | MG | |
| Residue number of the metal in the PDB | 1368 | |
| Chain of the metal in the PDB | C | |
| Atom name of the metal in the PDB | MG | |
| Download the coordinates file of the metal site | NOTES ON PDB: | |
| First Coordination Sphere | ||||||
| Ligand Type | Ligand Identity | Residue In MACiE | Donors | Bind Mode | Catalytic? | Notes |
| residue | ASP 173 C | ASP 173 A | OD1 | monodentate | No | - |
| residue | ASN 202 C | ASN 202 A | OD1 | monodentate | No | - |
| residue | PHE 204 C | PHE 204 A | O | monodentate | No | - |
| cofactor | TDP 1370 C | - | O12,O21 | bidentate | No | - |
| water | HOH 95 _ | - | O | monodentate | No | - |

![Image of [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine](/thornton-srv/databases/MACiE/images/C15972.gif)



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